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54,099 results for “Expression”
Large captivity effect based on gene expression comparisons between captive and wild shrew brains
<p class="MsoNormal">Compared to their free-ranging counterparts, wild animals in captivity are subject to different conditions with lasting effects on their physiology and behavior. Alterations in gene expression in response to environmental changes occur upstream of physiological and behavioral phenotypes, but there are no experiments analyzing differential gene expression in captive vs. free-ranging mammals. We assessed gene expression profiles of three brain regions (cortex, olfactory bulb, and hippocampus) of wild juvenile shrews (<em>Sorex araneus</em>) in comparison to shrews kept in captivity for two months. We found hundreds of differentially expressed genes in all three brain regions, suggesting a large and uniform captivity effect. Many of the downregulated genes in captive shrews significantly enrich pathways associated with neurodegenerative disease (p<0.001), oxidative phosphorylation (p<0.001), and genes encoding ribosomal proteins (p<0.001). Transcriptomic changes associated with captivity in the shrew resemble responses identified in several human pathologies, such as major depressive disorder and neurodegeneration. Thus, not only does captivity impact brain function and expression, but captivity effects may also confound analyses of natural physiological processes in wild individuals under captive conditions.</p>
Phase I/II Study of Autologous T Cells to Express T-Cell Receptors (TCRs) in Subjects With Solid Tumors
ClinicalTrials.gov study NCT05194735. IPD Sharing: NO. Countries: 1. Publications: 1.
T Cell Receptor Immunotherapy Targeting NY-ESO-1 for Patients With NY-ESO-1 Expressing Cancer
ClinicalTrials.gov study NCT01967823. IPD Sharing: NO. Countries: 1. Publications: 3.
Safety and Tolerability of a Modified Vaccinia Ankara (MVA)-Based Vaccine Modified to Express Brachyury and T-cell Costimulatory Molecules (MVA-Brachyury-TRICOM)
ClinicalTrials.gov study NCT02179515. IPD Sharing: NO. Countries: 1. Publications: 4.
Effect of Cyclosporine Therapy on Gene Expression in Patients With Large Granular Lymphocyte Leukemia
ClinicalTrials.gov study NCT00363779. IPD Sharing: Not stated. Countries: 1. Publications: 3.
PCP Use of a Gene Expression Test (Corus CAD or ASGES) in Coronary Artery Disease Diagnosis
ClinicalTrials.gov study NCT01594411. IPD Sharing: Not stated. Countries: 1. Publications: 2.
QUILT-3.038: Active Immunotherapy CEA Vaccine in Patients With Malignancies Expressing CEA
ClinicalTrials.gov study NCT01147965. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Study of REGN4018 (Ubamatamab) Administered Alone or in Combination With Cemiplimab in Adult Patients With Recurrent Ovarian Cancer or Other Recurrent Mucin-16 Expressing (MUC16+) Cancers
ClinicalTrials.gov study NCT03564340. IPD Sharing: YES. Countries: 10. Publications: 0.
Expressive Interviewing Agents to Support Health-Related Behavior Change
ClinicalTrials.gov study NCT05949840. IPD Sharing: NO. Countries: 1. Publications: 1.
T Cells Expressing a Fully-human AntiCD19 Chimeric Antigen Receptor for Treating B-cell Malignancies
ClinicalTrials.gov study NCT02659943. IPD Sharing: NO. Countries: 1. Publications: 1.
Plant Cell Expressed Recombinant Human Glucocerebrosidase Extension Trial
ClinicalTrials.gov study NCT00705939. IPD Sharing: Not stated. Countries: 8. Publications: 2.
Early Initiation of Milk Expression in Mothers of Very Low Birth Weight Infants
ClinicalTrials.gov study NCT01892085. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase 1 Study of Mixed Bacteria Vaccine (MBV) in Patients With Tumors Expressing NY-ESO-1 Antigen
ClinicalTrials.gov study NCT00623831. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study Of Changes In PD-L1 Expression During Preoperative Treatment With Nab-Paclitaxel And Pembrolizumab In Hormone Receptor-Positive Breast Cancer
ClinicalTrials.gov study NCT02999477. IPD Sharing: NO. Countries: 1. Publications: 2.
"Expressive Writing Psychological Health Migrants (EWPHM)
ClinicalTrials.gov study NCT04816032. IPD Sharing: YES. Countries: 1. Publications: 1.
T Cell Receptor Immunotherapy Targeting NY-ESO-1 for Patients With NY-ESO-1 Expressing Melanoma
ClinicalTrials.gov study NCT02062359. IPD Sharing: NO. Countries: 1. Publications: 3.
Biomarker-Driven Therapy With Nivolumab and Ipilimumab in Treating Patients With Metastatic Hormone-Resistant Prostate Cancer Expressing AR-V7
ClinicalTrials.gov study NCT02601014. IPD Sharing: NO. Countries: 1. Publications: 2.
A Phase II Trial Assessing Nivolumab in Class II Expressing Microsatellite Stable Colorectal Cancer
ClinicalTrials.gov study NCT03981146. IPD Sharing: NO. Countries: 1. Publications: 0.
Inhibitor Masking Device & Sodium Channel, Voltage Gated, Type IX Alpha Subunit (SCN9) Gene Expression
ClinicalTrials.gov study NCT01412918. IPD Sharing: NO. Countries: 1. Publications: 1.
Expressive Writing in Kidney Transplant Patients
ClinicalTrials.gov study NCT04143178. IPD Sharing: YES. Countries: 1. Publications: 19.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.