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884 results for “Nicotine”
Effect of prenatal exposure to nicotine on kidney structure and gene expression in rats
GEO Series GSE29677. Rattus norvegicus. 4 samples. Type: Expression profiling by array.
Paternal nicotine exposure promotes hepatic fibrosis in offspring
GEO Series GSE155308. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Dataset related to the article " Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca2+ Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells"
<p>This record contains raw data related to the article “Nicotinic Acid Adenine Dinucleotide Phosphate Induces Intracellular Ca<sup>2+</sup> Signalling and Stimulates Proliferation in Human Cardiac Mesenchymal Stromal Cells"</p> <p>Abstract</p> <p>Nicotinic acid adenine dinucleotide phosphate (NAADP) is a newly discovered second messenger that gates two pore channels 1 (TPC1) and 2 (TPC2) to elicit endo-lysosomal (EL) Ca<sup>2+</sup> release. NAADP-induced lysosomal Ca<sup>2+</sup> release may be amplified by the endoplasmic reticulum (ER) through the Ca<sup>2+</sup>-induced Ca<sup>2+</sup> release (CICR) mechanism. NAADP-induced intracellular Ca<sup>2+</sup> signals were shown to modulate a growing number of functions in the cardiovascular system, but their occurrence and role in cardiac mesenchymal stromal cells (C-MSCs) is still unknown. Herein, we found that exogenous delivery of NAADP-AM induced a robust Ca<sup>2+</sup> signal that was abolished by disrupting the lysosomal Ca<sup>2+</sup> store with Gly-Phe β-naphthylamide, nigericin, and bafilomycin A1, and blocking TPC1 and TPC2, that are both expressed at protein level in C-MSCs. Furthermore, NAADP-induced EL Ca<sup>2+</sup> release resulted in the Ca<sup>2+</sup>-dependent recruitment of ER-embedded InsP<sub>3</sub>Rs and SOCE activation. Transmission electron microscopy revealed clearly visible membrane contact sites between lysosome and ER membranes, which are predicted to provide the sub-cellular framework for lysosomal Ca<sup>2+</sup> to recruit ER-embedded InsP<sub>3</sub>Rs through CICR. NAADP-induced EL Ca<sup>2+</sup> mobilization via EL TPC was found to trigger the intracellular Ca<sup>2+</sup> signals whereby Fetal Bovine Serum (FBS) induces C-MSC proliferation. Furthermore, NAADP-evoked Ca<sup>2+</sup> release was required to mediate FBS-induced extracellular signal-regulated kinase (ERK), but not Akt, phosphorylation in C-MSCs. These finding support the notion that NAADP-induced TPC activation could be targeted to boost proliferation in C-MSCs and pave the way for future studies assessing whether aberrant NAADP signaling in C-MSCs could be involved in cardiac disorders.</p>
Paternal nicotine enhances fear memory, reduces nicotine administration and alters hippocampal genetic and neural function in offspring
GEO Series GSE140905. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.