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1,973 results for “T cell receptor”
CAR NK cell production from human cord blood cells is enhanced by stimulation of the IL15 receptor on NK progenitor cells
GEO Series GSE295031. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Data from: High-throughput sequencing of the T-cell receptor beta chain gene distinguishes two subgroups of cutaneous T-cell lymphoma
[No abstract entered]
Origin and evolutionary malleability of T cell receptor α diversity (zipped files for GitHub code)
<p>Lymphocytes of vertebrate adaptive immune systems acquired the capability to</p> <p>assemble, from split genes in the germline, billions of functional antigen receptors.</p> <p>These receptors show specificity; unlike the broadly tuned receptors of the innate</p> <p>system, antibodies (Ig) expressed by B lymphocytes, for instance, can faithfully</p> <p>distinguish between the two enantiomers of organic acids4 whereas T cell receptors</p> <p>(TCRs) reliably recognize single amino acid replacements in their peptide antigens5.</p> <p>In developing lymphocytes, antigen receptor genes (AgRs) are assembled from a</p> <p>comparatively small set of germline-encoded genetic elements in a process referred</p> <p>to as V(D)J recombination6,7. Potential self-reactivity of some AgRs arising from the</p> <p>quasi-random somatic diversification is suppressed by several robust control</p> <p>mechanisms. For decades, scientists have puzzled over the evolutionary origin of</p> <p>somatically diversifying antigen receptors. It has remained unclear how, at the</p> <p>inception of this mechanism, immunologically beneficial expanded receptor diversity</p> <p>was traded against the emerging risk of destructive self-recognition. Here, we explore</p> <p>the hypothesis that sequence microhomologies marking the ends of recombining</p> <p>elements are the crucial targets of selection determining the outcome of nonhomologous</p> <p>end joining-based repair of DNA double-strand breaks generated during</p> <p>RAG-mediated recombination in early vertebrates. We find that, across the main clades</p> <p>of jawed vertebrates, TCR α repertoire diversity is best explained by species-specific</p> <p>extents of such sequence microhomologies. Thus, selection of germline sequence</p> <p>composition of rearranging elements emerges as a major factor determining the</p> <p>degree of diversity of somatically generated AgRs.</p>
Expression of the Inhibitory Receptors on Lymphocytes T Cells After Lung Cancer Surgery.
ClinicalTrials.gov study NCT03549546. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of CXCR5 Modified EGFE Chimeric Antigen Receptor Autologous T Cells in EGFR- Positive Patients With Advanced Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT04153799. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Anakinra in Preventing Severe Chimeric Antigen Receptor T-Cell Related Encephalopathy Syndrome in Patients With Recurrent or Refractory Large B-cell Lymphoma
ClinicalTrials.gov study NCT04205838. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Treatment of CD19 Chimeric Antigen Receptor T Cells for Pediatric Patients With CD19-positive B-cell Acute Lymphoblastic Leukemia Who Are Indicated for Hematopoietic Stem Cell Transplantation
ClinicalTrials.gov study NCT06247501. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Chimeric Antigen Receptor T Cells Targeting Glypican-3
ClinicalTrials.gov study NCT03884751. IPD Sharing: NO. Countries: 1. Publications: 0.
The Clinical Application of Chimeric Antigen Receptor T Cells in the Treatment of CD19 Positive Recurrent Refractory B Cell-derived Hematological Malignancies
ClinicalTrials.gov study NCT04184414. IPD Sharing: NO. Countries: 1. Publications: 0.
Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer
ClinicalTrials.gov study NCT06253520. IPD Sharing: YES. Countries: 1. Publications: 0.
Autologous T Cells Lentivirally Transduced to Express L1CAM-Specific Chimeric Antigen Receptors in Treating Patients With Locally Advanced and Unresectable or Metastatic Small Cell Neuroendocrine Pros
ClinicalTrials.gov study NCT06094842. IPD Sharing: NO. Countries: 1. Publications: 0.
A Phase 1/2 Study of T-cell Expressing an Anti-CD22 Chimeric-Antigen Receptor (SHB-04-CD22) in Patients With CD22-expressing B-cell Malignancies
ClinicalTrials.gov study NCT07135466. IPD Sharing: YES. Countries: 1. Publications: 0.
Afatinib and Cetuximab in Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Positive Non-small-cell Lung Cancer
ClinicalTrials.gov study NCT03727724. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
3RD GENERATION GD2 SPECIFIC CHIMERIC ANTIGEN RECEPTOR TRANSDUCED AUTOLOGOUS NATURAL KILLER T-CELLS FOR NEUROBLASTOMA
ClinicalTrials.gov study NCT02439788. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Natural Killer Cells Functions, Tumoral Escape to Immune System and Regulation of Natural Cytotoxixity Receptors in Haematological Malignancies
ClinicalTrials.gov study NCT01915992. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Anti-BCMA Chimeric Antigen Receptor T Cells for Relapsed or Refractory Multiple Myeloma
ClinicalTrials.gov study NCT05577000. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study of Onartuzumab in Combination With Erlotinib in Patients With MET-Positive Stage IIIB or IV Non-Small Cell Lung Cancer Carrying an Activating Epidermal Growth Factor Receptor (EGFR) Mutation
ClinicalTrials.gov study NCT01887886. IPD Sharing: Not stated. Countries: 8. Publications: 0.
Program Cell Death Receptor 1 in Mycobacterium Avium Complex Lung Disease
ClinicalTrials.gov study NCT02779049. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Anti-Angiotensin-Receptor 1 (ATR1)-, Anti-Endothelin-Receptor A (ETRA)-Antibodies and T Cells in Cardiomyopathy
ClinicalTrials.gov study NCT02319590. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Chimeric Antigen Receptor T Cell Therapy Redirected to CD4 (CD4CAR)as a Second Line Treatment for Chronic Myelomonocytic Leukemia, CMML.
ClinicalTrials.gov study NCT06071624. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.