Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
906
datasets available to search
ShareScore release 0.9.0
Dataset results
906 results for “atherosclerosis”
Single cell RNA-seq analysis of endothelial cells during diabetic atherosclerosis
GEO Series GSE248065. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
CCL17-expressing dendritic cells are crucial for the development of atherosclerosis
GEO Series GSE13642. Mus musculus. 2 samples. Type: Expression profiling by array.
Imprints of atherosclerosis are present in circulating T cells of patients with Familial Hypercholesterolemia
GEO Series GSE6088. Homo sapiens. 23 samples. Type: Expression profiling by array.
Aryl-hydrocarbon receptor in smooth muscle cells protect against dioxin induced adverse remodeling of atherosclerosis [ATAC-seq]
GEO Series GSE276145. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
CCL17-expressing dendritic cells are crucial for the development of atherosclerosis: T cell priming
GEO Series GSE13592. Mus musculus. 3 samples. Type: Expression profiling by array.
CEBPB drives endothelial pathological phenotype and promotes atherosclerosis by directly upregulating TGFBR1 expression [CUT&Tag-Seq]
GEO Series GSE278348. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Altered lncRNAs transcriptomic profiles in atherosclerosis-induced ischemic stroke
GEO Series GSE146882. Homo sapiens. 20 samples. Type: Non-coding RNA profiling by array.
Hypothalamic CRH Neuronal Activation Triggers Splenic Cell Proliferation and Promotes Atherosclerosis
GEO Series GSE312004. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
MicroRNA signature in murine atherosclerosis
GEO Series GSE26731. Mus musculus. 30 samples. Type: Non-coding RNA profiling by array.
Lack of tolerogenic CD11c+ cells drives early atherosclerosis [scRNA-seq]
GEO Series GSE275865. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Acetate controls endothelial-to-mesenchymal transition during atherosclerosis
GEO Series GSE224940. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Effect of TUDCA on the artery which suffered from the atherosclerosis in ApoE-/- mice
GEO Series GSE260610. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Acetate controls endothelial-to-mesenchymal transition during atherosclerosis [1]
GEO Series GSE224907. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Maternal high-fat diet aggravates the development of atherosclerosis in offspring via epigenetic memory (ATAC-Seq CUT&Tag)
GEO Series GSE276350. Mus musculus. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dataset related to the article "Impact of oxidative stress and protein S-Glutathionylation in aortic valve sclerosis patients with overt atherosclerosis
<p>This record contains raw data related to the article "Impact of oxidative stress and protein S-Glutathionylation in aortic valve sclerosis patients with overt atherosclerosis"</p> <p>Abstract: Aortic valve sclerosis (AVSc) is characterized by non-uniform thickening of the leaflets without hemodynamic changes. Endothelial dysfunction, also caused by dysregulation of glutathione homeostasis expressed as ratio between its reduced (GSH) and its oxidised form (GSSG), could represent one of the pathogenic triggers of AVSc. We prospectively enrolled 58 patients with overt atherosclerosis and requiring coronary artery bypass grafting (CABG). The incidence of AVSc in the studied population was 50%. The two groups (No-AVSc and AVSc) had similar clinical characteristics. Pre-operatively, AVSc group showed significantly lower GSH/GSSG ratio than No-AVSc group (<em>p</em> = 0.02). Asymmetric dimethylarginine (ADMA) concentration was significantly higher in AVSc patients compared to No-AVSc patients (<em>p</em> < 0.0001). Explanted sclerotic aortic valves presented a significantly increased protein glutathionylation (Pr-SSG) than No-AVSc ones (<em>p</em> = 0.01). In vitro, inhibition of glutathione reductase caused β-actin glutathionylation, activation of histone 2AX, upregulation of α2 smooth muscle actin (<em>ACTA2</em>), downregulation of platelet and endothelial cell adhesion molecule 1 (<em>PECAM1</em>) and cadherin 5 (<em>CDH5</em>). In this study, we showed for the first time that the dysregulation of glutathione homeostasis is associated with AVSc. We found that Pr-SSG is increased in AVSc leaflets and it could lead to EndMT via DNA damage. Further studies are warranted to elucidate the causal role of Pr-SSG in aortic valve degeneration</p>
Dataset related to the article "12(S)-Hydroxyeicosatetraenoic acid downregulates monocyte-derived macrophage efferocytosis: new insights in atherosclerosis"
<p>This record contains raw data related to the article “12(S)-Hydroxyeicosatetraenoic acid downregulates monocyte-derived macrophage efferocytosis: new insights in atherosclerosis"</p> <p>Abstract:The involvement of 12(S)-hydroxyeicosatetraenoic acid (12(S)-HETE), a 12-lipooxygenase product of arachidonic acid, has been suggested in atherosclerosis. However,its effecton macrophage functions is not completely understood, so far. The uptake of apoptotic cells (efferocytosis) by macrophages is an anti-inflammatory process, impaired in advanced atherosclerotic lesions. This process induces the release of the anti-inflammatory cytokine interleukin-10 (IL-10), and it is regulated by Rho-GTPases, whose activation involves the isoprenylation, a modification inhibited by statins. We assessed 12-HETE levels in serum of coronary artery disease (CAD) patients, and explored12(S)-HETE invitro effect on monocyte-derived macrophage (MDM) efferocytosis.Sixty-four CAD patients and 24 healthy subjects (HS) were enrolled. Serum12-HETE levels were measured using a tandem mass spectrometry method. MDMs, obtained from a spontaneous differentiation of adherent monocytes, were treated with12(S)-HETE (10–50 ng/mL). Efferocytosis and RhoA activation were evaluated by flow cytometry. IL-10 was measured by ELISA. CAD patients showed increased 12-HETE serum levels compared to HS (665.2 [438.1–896.2] ng/mL and 525.1 [380.1–750.1] ng/mL, respectively, p < 0.05) and reduced levels of IL-10. MDMs expressed the12(S)-HETE cognate receptor GPR31. CAD-derived MDMs displayed defective efferocytosis vs HS-MDMs (9.4 [7.7–11.3]% and 11.1 [9.6–14.1]% of MDMs that have engulfed apoptotic cells, respectively, p < 0.01). This reduction is marked in MDMs obtained from patients not treated with statin (9.3 [7.4–10.6]% statin-free CAD vs HS, p=0.01; and 9.9 [8.6–11.6]% statin-treated CAD vs HS, p=0.07). The in vitro treatment of MDMs with12 (S)-HETE (20ng/mL) induced 20% decrease of efferocytosis (p < 0.01) and 71% increase of RhoA activated form(p < 0.05). Atorvastatin (0.1μM) counteracted these 12(S)-HETE-mediated effects.These results show a12(S)-HETE pro-inflammatory effect and suggest a new potential contribution of this mediator in the development of atherosclerosis.</p> <p> </p>
Supplementary material for "Identification of Protein Networks and Biological Pathways Driving the Progression of Atherosclerosis in Human Carotid Arteries through Mass Spectrometry-Based Proteomics"
Open the record for dataset details and reuse information.
Dataset related to the article: "Netrin-1 in Atherosclerosis: Relationship between Human Macrophage Intracellular Levels and In Vivo Plaque Morphology"
<p>This record contains raw data related to the article: "Netrin-1 in Atherosclerosis: Relationship between Human Macrophage Intracellular Levels and In Vivo Plaque Morphology"</p> <p>Abstract: Netrin-1 is a laminin-like protein that plays a pivotal role in cell migration and, according to the site of its release, exerts both pro and anti-atherosclerotic functions. Macrophages, key cells in atherosclerosis, are heterogeneous in morphology and function and different subpopulations may support plaque progression, stabilization, and/or regression. Netrin-1 was evaluated in plasma and, together with its receptor UNC5b, in both spindle and round monocyte-derived macrophages (MDMs) morphotypes from coronary artery disease (CAD) patients and control subjects. In CAD patients, plaque features were detected in vivo by optical coherence tomography. CAD patients had lower plasma Netrin-1 levels and a higher MDMs expression of both protein and its receptor compared to controls. Specifically, a progressive increase in Netrin-1 and UNC5b was evidenced going from controls to stable angina (SA) and acute myocardial infarction (AMI) patients. Of note, spindle MDMs of AMI showed a marked increase of both Netrin-1 and its receptor compared to spindle MDMs of controls. UNC5b expression is always higher in spindle compared to round MDMs, regardless of the subgroup. Finally, CAD patients with higher intracellular Netrin-1 levels showed greater intraplaque macrophage accumulation in vivo. Our findings support the role of Netrin-1 and UNC5b in the atherosclerotic process.</p>
Utilizing combined spatial transcriptomics to elucidate localized immune responses within human coronary arteries throughout the progression of atherosclerosis
GEO Series GSE277170. blank sample; Homo sapiens. 56 samples. Type: Other.
Vascular Smooth Muscle Cell-derived KIF13B Protects Against Atherosclerosis: Evidence from Humans and Mice
GEO Series GSE314838. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.