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Fig. 3 in Design, synthesis and screening of a drug discovery library based on an Eremophila-derived serrulatane scaffold
Fig. 3. Microscopic images of the skinny (Skn) phenotype in L4s induced by compound 3 compared with the wild-type (WT) phenotype control (cultured in culture medium + 0.25% DMSO); the bottom panels enlarged from the dashed/ boxed areas in the upper panels.
Performance characteristics of an HIV risk screening tool in Uganda
<p><strong>Introduction</strong>: Improving HIV testing efficiency has been documented to save financial and material resources for health. In October 2019, the Ministry of HealthH Uganda deployed an HIV risk screening tool for use in 24 health facilities targeting clients aged 15 years and above in both outpatient and Voluntary Counselling and Testing departments.</p> <p><strong>Methods</strong>: We conducted a retrospective secondary data analysis of routinely collected HIV risk screening program data in Uganda, collected from October to November 2019, to determine the performance characteristics of the adolescent and adult HIV risk screening tool in public health facility settings. Statistical measures for the risk screening tool performance included sensitivity, specificity, positive and negative predictive values, and cost analysis. </p> <p><strong>Results</strong>: A total of 19,854 clients were screened for HIV testing eligibility; we excluded 150 records with incomplete testing information. The overall positivity rate (cluster-weighted prevalence of HIV) among those screened was 4.5% (95% CI: 4.1–4.8%) versus 3.71% (95% CI: 3.06–4.50) among those not screened. The sensitivity and specificity of the risk screening tool were found to be 90.7% (95% CI: 88.4%, 92.7%) and 75.8%, (75.2–76.4) respectively. With screening, the number needed to test to identify one PLHIV was reduced from 27 to 22. Although risk screening would have led to a 24.5% (4,825/19,704) reduction in testing volume, 9.3% (68/732) of PLHIV would have been missed as they were misclassified as not eligible for testing. The cost per PLHIV identified fell by 3% from $69 without screening to $66.9 with the implementation of the screening tool. </p> <p><strong>Conclusions</strong>: The use of an HIV risk screening tool in OPD settings in Uganda demonstrated improved HIV testing efficiency by reducing testing volumes but resulted in screening out of nine of every 100 people living with HIV. The team recommends the use of scientifically validated HIV risk screening tools, and a need to explore the use of HIV self-testing as a test for triage.</p>
Fig. 5 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 5. Possible biosynthetic pathway for the nitro derivatives, catecholic alkaloids and their sulfonates from P. oleracea (DDC: dopa decarboxylase; RNS: reactive nitrogen species; TH: tyrosine hydroxylase).
Fig. 6 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 6. Dose-dependent inhibition of nitro derivative 12 against LPS-induced NO production in RAW 264.7 macrophage cells (n = 3) (****p <0.0001, versus vehicle control, ####p <0.0001, versus LPS-treated model, 3,4-dihydroxy-benzohydroxamic acid (Didox) was used as the positive control with IC value of 70 μM).
Fig. 4 in Catecholic alkaloid sulfonates and aromatic nitro compounds from Portulaca oleracea and screening of their anti-inflammatory and anti-microbial activities
Fig. 4. Calculated and experiment ECD of compounds 4, 10–11, 15–17 and their possible stereostructures
Fig. 3 in Characterization of phytochemicals in the roots of wild herbaceous peonies from China and screening for medicinal resources
Fig. 3. The range and distribution of the five metabolite categories in 20 populations of sect. Paeonia distributed in China. Median values are shown as horizontal lines within each box while 50% of the data is presented within the box. Data outside each box are indicated by black dots.
Fig. 2 in Characterization of phytochemicals in the roots of wild herbaceous peonies from China and screening for medicinal resources
Fig. 2. Chemical structures of major compounds identified in roots of sect. Paeonia native to China.
Fig. 4 in Characterization of phytochemicals in the roots of wild herbaceous peonies from China and screening for medicinal resources
Fig. 4. Hierarchical cluster dendritic diagram of 20 populations of sect. Paeonia distributed in China.
Fig. 1 in Characterization of phytochemicals in the roots of wild herbaceous peonies from China and screening for medicinal resources
Fig. 1. Representative HPLC chromatographic profiles of roots at 254 nm in samples from sect. Paeonia native to China. A: P2 (Paeonia lactiflora), B: P7 (P. anomala subsp. veitchii), C: P9 (P. anomala subsp. anomala), D: P10 (P. sterniana), E: P11 (P. emodi), F: P12 (P. obovata subsp. willottiae), G: P16 (P. obovata subsp. obovata), H: P18 (P. mairei), I: P20 (P. intermedia).
Non-Targeted Screening of Contaminants of Emerging Concern in the Glen Valley Wastewater Treatment Plant, Botswana
<p>All raw data files associated with the manuscript titled "Non-Targeted Screening of Contaminants of Emerging Concern in the Glen Valley Wastewater Treatment Plant, Botswana". These include the quality control samples, blanks and wastewater samples analysed on a waters fusion orbitrap operation in positive mode while aquiring MS/MS data. LC data is also included. </p>
Newborn Bloodspot Screening Animation
<p>An animation to provide information about Newborn Bloodspot Screening in the UK</p>
Latrine screen, Roman Villa of Els Munts, Spain
Latrine screen partition from the Roman Villa of Els Munts (Tarragona, Spain), dated in the mid-2nd century AD. Decorated with a relief depicting a dolphin. From the baths building of the Roman villa of Els Munts. 556 photos completely processed in Reality Capture. The project was done with the support of the National Archaeological Museum of Tarragona and the Agència Catalana del Patrimoni Cultural. Catalog No. MNAT 45394. Museu Nacional Arqueològic de Tarragona (2019): Tarraco: Exposición de síntesis. Generalitat de Catalunya Publicacions. Source: Objaverse 1.0 / Sketchfab
Iris Vascular Area Density-Based Preoperative Pain-Risk Screening and Intervention in Second-Eye Cataract Surgery
ClinicalTrials.gov study NCT07291089. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Survey Study on Barrett's Esophagus Screening
ClinicalTrials.gov study NCT04408105. IPD Sharing: NO. Countries: 1. Publications: 1.
National Liver Cancer Screening Trial
ClinicalTrials.gov study NCT06084234. IPD Sharing: NO. Countries: 1. Publications: 1.
Cervical Cancer Screening in Madagascar Using Smartphone Photos and Mobile Telemedicine
ClinicalTrials.gov study NCT02693379. IPD Sharing: YES. Countries: 1. Publications: 2.
Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge
ClinicalTrials.gov study NCT02639299. IPD Sharing: NO. Countries: 1. Publications: 1.
Screening Emotions in Adolescents at the Hospital for mTBI
ClinicalTrials.gov study NCT06370520. IPD Sharing: NO. Countries: 1. Publications: 0.
A Pan-cancer Screening and Diagnosis Model Based on Abdominal CT Was Established
ClinicalTrials.gov study NCT06614179. IPD Sharing: YES. Countries: 1. Publications: 1.
Screening for Breast Cancer With Digital Breast Tomosynthesis
ClinicalTrials.gov study NCT02698202. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.