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1,985
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1,985 results for “Antigen”
Antigen-specific CD8+ T cell transcriptome and splicing changes after costimulation in vivo [Costimulation CD8 Repeat]
GEO Series GSE200237. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Targeting an alternate Wilms Tumor Antigen-1 peptide bypasses immunoproteasome dependency
GEO Series GSE190501. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
CCL21 Expression in Beta Cells Induces Antigen-Expressing Stromal Cell Networks in the Pancreas and Prevents Autoimmune Diabetes in Mice
GEO Series GSE130979. Mus musculus. 27 samples. Type: Expression profiling by high throughput sequencing.
Protective interaction of human phagocytic APC subsets with Cryptococcus neoformans induces genes associated with metabolism and antigen presentation
GEO Series GSE216963. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Discovery of tumor specific antigens in acute myeloid leukemia.
GEO Series GSE147524. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
Predicting Antigen-Specificities of Orphan T Cell Receptors from Cancer Patients with TCRpcDist
GEO Series GSE249741. Homo sapiens. 6 samples. Type: Other.
Antigen specificity of clonally-enriched CD8+ T cells in multiple sclerosis
GEO Series GSE291328. Homo sapiens. 36 samples. Type: Other.
Host-informed molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine [Ribo-seq]
GEO Series GSE159336. Komagataella phaffii. 8 samples. Type: Expression profiling by high throughput sequencing.
Epitope mapping of 4 monoclonal antibodies directed against Neisserial Heparin Binding Antigen by peptide microarray
GEO Series GSE98882. Neisseria meningitidis serogroup B; Homo sapiens. 4 samples. Type: Protein profiling by protein array.
The MRN complex promotes DNA repair by homologous recombination and restrains antigenic variation in African trypanosomes
<p>Sanger sequencing of PCR products to determine MMEJ repair junctions.</p>
Data from: An antibody screen of a Plasmodium vivax antigen library identifies novel merozoite proteins associated with clinical protection
Background. Elimination of Plasmodium vivax malaria would be greatly facilitated by the development of an effective vaccine. A comprehensive and systematic characterization of antibodies to P. vivax antigens in exposed populations is useful in guiding rational vaccine design. Methodology/Principal Findings. In this study, we investigated antibodies to a large library of P. vivax entire ectodomain merozoite proteins in 2 Asia-Pacific populations, analysing the relationship of antibody levels with markers of current and cumulative malaria exposure, and socioeconomic and clinical indicators. 29 antigenic targets of natural immunity were identified. Of these, 12 highly-immunogenic proteins were strongly associated with age and thus cumulative lifetime exposure in Solomon Islanders (P<0.001-0.027). A subset of 6 proteins, selected on the basis of immunogenicity and expression levels, were used to examine antibody levels in plasma samples from a population of young Papua New Guinean children with well-characterized individual differences in exposure. This analysis identified a strong association between reduced risk of clinical disease and antibody levels to P12, P41, and a novel hypothetical protein that has not previously been studied, PVX_081550 (IRR 0.46-0.74; P<0.001-0.041). Conclusion/Significance. These data emphasize the benefits of an unbiased screening approach in identifying novel vaccine candidate antigens. Functional studies are now required to establish whether PVX_081550 is a key component of the naturally-acquired protective immune response, a biomarker of immune status, or both.
Hallmarks of T-cell exhaustion and antigen experience are absent in multiple myeloma from diagnosis to maintenance therapy
<p>Code and data associated with Shasha et al., "Hallmarks of T-cell exhaustion and antigen experience are absent in multiple myeloma from diagnosis to maintenance therapy" (<a href="https://doi.org/10.1182/blood.2024025655" target="_blank" rel="noopener">https://doi.org/10.1182/blood.2024025655</a>). Description of files below:</p> <p>scRNA-seq_code.tar: Python notebooks for analysis of scRNA-seq data, including import and figure generation</p> <p>adata-rev.h5ad: processed CD8 T cell scRNA-seq data from all patients and samples combined. Includes condensed TCR info (refer to columns 'cdr3' for example; 'chain_id' was determined per batch and can be ignored)</p> <p>ics_tsv_repeat_dat.csv: ICS metadata</p> <p>cytof_ics_repeat_data.tar: normalized ICS tsv and fcs files from all patients and samples</p> <p>ics_repeat_analysis.R: R code for analysis of ICS data</p> <p>cytof_data.tar: CyTOF fcs and txt files (bead normalized and compensated, gated to CD8 T cells)</p> <p> </p>
Data from: Variations in HLA-B cell surface expression, half-life and extracellular antigen receptivity
The highly polymorphic human leukocyte antigen (HLA) class I molecules present peptide antigens to CD8+ T cells, inducing immunity against infections and cancers. Quality control mediated by peptide loading complex (PLC) components is expected to ensure the cell surface expression of stable peptide-HLA class I complexes. This is exemplified by HLA-B*08:01 in primary human lymphocytes, with both expression level and half-life at the high end of the measured HLA-B expression and stability hierarchies. Conversely, low expression on lymphocytes is measured for three HLA-B allotypes that bind peptides with proline at position 2, which are disfavored by the transporter associated with antigen processing. Surprisingly, these lymphocyte-specific expression and stability differences become reversed or altered in monocytes, which display larger intracellular pools of HLA class I than lymphocytes. Together, the findings indicate that allele and cell-dependent variations in antigen acquisition pathways influence HLA-B surface expression levels, half-lives and receptivity to exogenous antigens.
Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis
<p>Datasets and code relevant to the article titled "Antigen-driven colonic inflammation is associated with development of dysplasia in primary sclerosing cholangitis"</p>
Changes in Prostate Specific Antigen Levels During Synergo Therapy-Intravesical Chemotherapy Instillations Combined With Hyperthermia
ClinicalTrials.gov study NCT00491296. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prostate Specific Membrane Antigen (PMSA)-Based PET Imaging of High Risk Prostate Cancer
ClinicalTrials.gov study NCT03976843. IPD Sharing: YES. Countries: 1. Publications: 0.
Accuracy of Dilution of EUS-FNA Pancreatic Cyst Fluid for Carcinoembryonic Antigen (CEA) Measurement
ClinicalTrials.gov study NCT01494077. IPD Sharing: Not stated. Countries: 1. Publications: 0.
RT201(Tumor Antigen-specific Macrophage Tumor Vaccine)
ClinicalTrials.gov study NCT05930301. IPD Sharing: NO. Countries: 1. Publications: 0.
Galactomannan Antigen in Bronchoalveolar Lavage in the Diagnosis of Invasive Aspergillosis in Neutropenic Patients
ClinicalTrials.gov study NCT01128907. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study of CXCR5 Modified EGFE Chimeric Antigen Receptor Autologous T Cells in EGFR- Positive Patients With Advanced Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT04153799. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.