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Dataset results
920 results for “Functional analysis”
System-wide analysis of Dhx36 function in skeletal muscle satellite cells reveals its binding with 5’UTR G4 structure to promote Gnai2 RNA translation [Polysome profiling]
GEO Series GSE151123. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Integrated multiomic analysis identifies functional epigenetic signatures regulating nucleotide excision repair (meRIP-seq)
GEO Series GSE161792. Homo sapiens. 16 samples. Type: Other.
In-Depth Functional Analysis of BRD9 in Fetal Hematopoiesis Reveals Context-Dependent Roles [ATAC-seq]
GEO Series GSE269139. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
comparison_cul4_as_light-Functional analysis of the SKP2 and CUL4 proteins
GEO Series GSE36655. Arabidopsis thaliana. 8 samples. Type: Expression profiling by array.
Functional analysis of miR-375 in oral squamous cell carcinoma cells
GEO Series GSE240389. Homo sapiens. 8 samples. Type: Expression profiling by array.
myb-Functional analysis of two Eucalyptus xylem MYB transcription factors overexpressed in Arabidopsis.
GEO Series GSE7996. Arabidopsis thaliana. 16 samples. Type: Expression profiling by array.
Expression analysis of epidermal barrier functions associated genes in HaCaT cell and mouse epidermis treated by All-trans retinoic acid and Nicotinamide
GEO Series GSE124183. Homo sapiens; Mus musculus. 7 samples. Type: Expression profiling by array.
Transcriptomic analysis and high throughput functional characterization of human induced pluripotent stem cell derived sensory neurons (scRNA-Seq)
GEO Series GSE275413. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Functional analysis of lipid acyl hydrolases in Arabidopsis antimicrobial defense: plp2 Botrytis cinerea
GEO Series GSE15972. Arabidopsis thaliana. 8 samples. Type: Expression profiling by array.
Taxonomic and functional diversity of the microbiome in a jet fuel contaminated site as revealed by combined application of in situ microcosms with metagenomic analysis
<p>Natural attenuation represents all processes that govern contaminant mass removal, which mainly occurs via microbial degradation in the environment. Although this process is intrinsic its rate and efficiency depend on multiple factors. This study aimed to characterize the microbial taxonomic and functional diversity in different aquifer sediments collected in the saturated zone and <em>in situ</em> microcosms (BACTRAP®s) amended with hydrocarbons (<sup>13</sup>C-labeled and non-labeled benzene, toluene and naphthalene) using 16S rRNA gene and “<em>shotgun</em>” Illumina high throughput sequencing at a jet-fuel contaminated site. The BACTRAP®s were installed to assess hydrocarbon metabolism by native bacteria. Results indicated that Proteobacteria, Actinobacteria and Firmicutes were the most dominant phyla (~98%) in the aquifer sediment samples. Meanwhile, in the benzene- and toluene-amended BACTRAP®s the phyla Firmicutes and Proteobacteria accounted for about 90% of total community. In the naphthalene-amended BACTRAP®, members of the SR-FBR-L83 family (Order Ignavibacteriales) accounted for almost 80% of bacterial community. Functional annotation of metagenomes showed that only the sediment sample located at the source zone border and with the lowest BTEX concentration, has metabolic potential to degrade hydrocarbons aerobically. On the other hand, <em>in situ</em> BACTRAP®s allowed enrichment of hydrocarbon-degrading bacteria. Metagenomic data suggest that fumarate addition is the main mechanism for hydrocarbon activation of toluene. Also, indications for methylation, hydroxylation and carboxylation as activation mechanisms for benzene anaerobic conversion were found. After 120 days of exposure in the contaminated groundwater, the isotopic analysis of fatty acids extracted from BACTRAP®s demonstrated the assimilation of isotopic labeled compounds in the cells of microbes expressed by strong isotopic enrichment. We propose that the microbiota in this jet-fuel contaminated site has metabolic potential to degrade benzene and toluene by a syntrophic process, between members of the families Geobacteraceae and Peptococcaceae (genus <em>Pelotomaculum</em>), coupled to nitrate, iron and/or sulfate reduction.</p>
Elucidating the mechanisms underlying left ventricular function recovery in patients with ischemic heart failure undergoing surgical remodeling: A 3-dimensional ultrasound analysis.
<p>Dataset from Castelvecchio S, Frigelli M, Sturla F, Milani V, Pappalardo OA, Citarella M, Menicanti L, Votta E. Elucidating the mechanisms underlying left ventricular function recovery in patients with ischemic heart failure undergoing surgical remodeling: A 3-dimensional ultrasound analysis. J Thorac Cardiovasc Surg. 2021 Feb 26:S0022-5223(21)00381-0. doi: 10.1016/j.jtcvs.2021.02.067. Epub ahead of print. PMID: 33781593.</p> <p>Abstract </p> <p><strong>Objective: </strong>The study objective was to elucidate the mechanisms of left ventricle functional recovery in terms of endocardial contractility and synchronicity after surgical ventricular reconstruction.</p> <p><strong>Methods: </strong>Real-time 3-dimensional transthoracic echocardiography was performed on 20 patients with anterior left ventricle remodeling and ischemic heart failure before surgical ventricular reconstruction and at 6-month follow-up, and on 15 healthy controls matched by age and body surface area. Real-time 3-dimensional transthoracic echocardiography datasets were analyzed through TomTec software (4D LV-Analysis; TomTec Imaging Systems GmbH, Unterschleissheim, Germany): Left ventricle volumes, ejection fraction, and global longitudinal strain were computed; the time-dependent endocardial surface yielded by 3-dimensional speckle-tracking echocardiography was postprocessed through in-house software to quantify local systolic minimum principal strain as a measure of fiber shortening and mechanical dispersion as a measure of fiber synchronicity.</p> <p><strong>Results: </strong>Compared with controls, patients with heart failure before surgical ventricular reconstruction showed lower ejection fraction (P < .0001) and significantly impaired mechanical dispersion (P < .0001) and minimum principal strain (P < .0001); the latter worsened progressively from left ventricle base to apex. After surgical ventricular reconstruction, global longitudinal strain improved from -6.7% to -11.3% (P < .0001); mechanical dispersion decreased in every left ventricle region (P ≤ .017) and mostly in the basal region, where computed mechanical dispersion values were comparable to physiologic values (P ≥ .046); minimum principal strain improved mostly in the basal region, changing from -16.6% to -22.3% (P = .0027).</p> <p><strong>Conclusions: </strong>At 6-month follow-up, surgical ventricular reconstruction was associated with significant recovery in global left ventricle function, improved mechanical dispersion indicating a more synchronous left ventricle contraction, and improved left ventricle fiber shortening mostly in the basal region, suggesting the major role of the remote myocardium in enhancing left ventricle functional recovery.</p>
Analysis of ASIC1a function and signalling
<p>The deposited files include the dataset of the experimental part of the submitted manuscript on the function of ASIC1a, as well as Matlab scripts of kinetic models that are part of the study.</p>
ARRIVE guidelines author checklist of "Structural and functional analysis reveals the catalytic mechanism and substrate binding mode of the broad-spectrum endolysin Ply2741"
Open the record for dataset details and reuse information.
Spreadsheet Files for Nuclear Membrane and Nuclear Pore Complex Structure and Function Analysis
<p>Associated DataSet for Manuscript on the Nuclear Membrane and Nuclear Pore Complex. Each file corresponds to a different figure in the manuscript. Open the files for the ReadME information to understand the data in the workbook. Further explanations can be provided if needed from the authors of the manuscript. </p>
Functional Enrichment Analysis of ALYREF
GEO Series GSE195701. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Functional Analysis and Gene Expression Profile of Umbilical Cord Blood Regulatory T Cells
GEO Series GSE22501. Homo sapiens. 10 samples. Type: Expression profiling by array.
Expression analysis of gene silenced barley to identify the function of a novel LRR-RLK (leucine-rich repeat receptor-like kinase)
GEO Series GSE34102. Hordeum vulgare. 12 samples. Type: Expression profiling by array.
Expression analysis of epidermal barrier functions associated genes in HaCaT cell treated by All-trans retinoic acid and Nicotinamide
GEO Series GSE124179. Homo sapiens. 3 samples. Type: Expression profiling by array.
Gene expression and functional analysis of GJB2 mutated HaCaT cell lines
GEO Series GSE200387. Homo sapiens. 12 samples. Type: Expression profiling by array.
Database analysed in the paper "Differential Item Functioning of the Mini-BESTest Balance Measure: A Rasch Analysis Study"
<p>Database analysed in the paper <em>"Differential Item Functioning of the Mini-BESTest Balance Measure: A Rasch Analysis Study"</em> published in the Int J Environ Res Public Health, 2023 Mar 15;20(6):5166. doi: 10.3390/ijerph20065166</p> <p>The file uploaded is the specification file for the first analysis run with Facets 3.84.0.</p> <p>Data can be found at the end of the specification file.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.