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1,723
datasets available to search
ShareScore release 0.9.0
Dataset results
1,723 results for “Reactivation”
Single cell RNA-seq reveals expansion of IGRP-reactive CD4+ T cells in recent onset type I diabetes (single-cell RNA-seq of CD8+ influenza-reactive T cells)
GEO Series GSE96564. Homo sapiens. 45 samples. Type: Expression profiling by high throughput sequencing.
Landscape of Monoallelic DNA Accessibility and Gene Regulatory Networks during Reprogramming to Naive Pluripotency and X Chromosome Reactivation [allele-specific analysis]
GEO Series GSE184987. Mus musculus. 47 samples. Type: Expression profiling by high throughput sequencing.
Identification of reactive CpGs and RNA expression in early COVID-19 through cis-eQTM analysis reflecting disease severity and recovery [RNA-seq]
GEO Series GSE300696. Homo sapiens. 346 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA-seq reveals expansion of IGRP-reactive CD4+ T cells in recent onset type I diabetes (single-cell RNA-seq of T-cell clone)
GEO Series GSE96562. Homo sapiens. 149 samples. Type: Expression profiling by high throughput sequencing.
A herpesvirus microRNA targets host microRNA processing to promote virus reactivation from latency [Lytic infection]
GEO Series GSE179865. Homo sapiens. 10 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Inactivation of BCL11A reactivates silenced human HbF in adult mice
GEO Series GSE28355. Mus musculus. 9 samples. Type: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic reactivation of tumor suppressor genes with CRISPRa technologies as precision therapy for hepatocellular carcinoma
GEO Series GSE211837. Homo sapiens. 16 samples. Type: Methylation profiling by array.
Tumor-reactive heterotypic CD8 T cell clusters from clinical samples
GEO Series GSE283942. Homo sapiens. 28 samples. Type: Expression profiling by high throughput sequencing; Other.
REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function
GEO Series GSE293026. Mus musculus. 26 samples. Type: Expression profiling by high throughput sequencing.
MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density.
GEO Series GSE84318. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Mitochondrial Hyperactivity and Reactive Oxygen Species Drive Innate Immunity to the Yellow Fever Virus-17D Live-Attenuated Vaccine
GEO Series GSE293880. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
MBD4 loss results in global reactivation of promoters and retroelements with low methylated CpG density.
GEO Series GSE66397. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
A Molecular Switch for Neuroprotective Astrocyte Reactivity
GEO Series GSE237675. Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Identification of reactive CpGs and RNA expression in early COVID-19 through cis-eQTM analysis reflecting disease severity and recovery [Bisulfite-Seq]
GEO Series GSE301082. Homo sapiens. 192 samples. Type: Methylation profiling by high throughput sequencing.
Analysis of miRNA expression profiles in reactivated neurons from latent PRV infection
GEO Series GSE202138. Rattus norvegicus. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Data from: Sleep disordered breathing is associated with brain vascular reactivity in spinal cord injury
Objective: Our goal was to determine the population-level odds of individuals with SCI experiencing fatigue and sleep apnea, to elucidate relationships with level and severity of injury, and to examine associations with abnormal cerebrovascular responsiveness. Methods: We used population-level data, meta-analyses, and primary physiological assessments to provide a large-scale integrated assessment of sleep-related complications after SCI. Population-level and meta-analyses included more than 60,000 able-bodied individuals and more than 1,800 individuals with SCI. Physiological assessments were completed on a homogenous sample of individuals with cervical SCI, and matched controls. We examined the prevalence of 1) self-reported chronic fatigue, 2) clinically-identified sleep apnea, and 3) cerebrovascular responsiveness to changing CO2. Results: Logistic regression revealed a 7-fold elevated odds of chronic fatigue after SCI [OR: 7.9, 95% CI: 3.5-16.2], and that fatigue and trouble sleeping are correlated with the level and severity of injury. We further show that those with SCI experience elevated risk of clinically-defined sleep-disordered breathing in more than 600 individuals with SCI [pooled OR: 3.1, 95% CI: 1.3-7.5]. We confirmed that individuals with SCI experience a high rate of clinically-defined sleep-apnea using primary polysomnography assessments. We then provide evidence using syndromic analysis that sleep-disordered breathing is a factor strongly associated with impaired cerebrovascular responsiveness to CO2 in patients with SCI. Conclusions: Individuals with SCI have an increased prevalence of sleep-disordered breathing, which may partially underpin their increased risk of stroke. There is thus a need to integrate sleep-related breathing examinations into routine care for individuals with SCI.
Parvalbumin expression in oligodendrocyte-like CG4 cells causes a reduction in mitochondrial volume, attenuation in reactive oxygen species production and a decrease in cell processes' length and branching
<p>Forebrain glial cells - ependymal cells and astrocytes -acquire upon injury- a “reactive” phenotype associated with parvalbumin (PV) upregulation. Since free radicals, e.g. reactive oxygen species (ROS) play a role in the pathogenesis of multiple sclerosis, and that PV-upregulation in glial cells is inversely correlated with the level of oxidative stress, we hypothesized that PV-upregulation might also protect oligodendrocytes by decreasing ROS production. Lentiviral transduction techniques allowed for PV overexpression in CG4 oligodendrocyte progenitor cells (OPCs). Depending on the growth medium CG4 cells can be maintained in an OPC-like state, or induced to differentiate into an oligodendrocyte (OLG)-like phenotype. While increased levels of PV had no effect on cell proliferation and invasiveness <em>in vitro</em>, PV decreased the mitochondria volume in CG4 cell bodies, as well as the mitochondrial density in CG4 processes in both OPC-like and OLG-like states. In line with the PV-induced global decrease in mitochondrial volume, elevated PV levels reduced transcript levels of mitochondrial transcription factors involved in mitochondria biogenesis. In differentiated PV-overexpressing CG4 cells with a decreased mitochondrial volume, UV-induced ROS production was lower than in control CG4 cells hinting towards a possible role of PV in counteracting oxidative stress. Unexpectedly, PV also decreased the length of processes in undifferentiated CG4 cells and moreover diminished branching of differentiated CG4 cell processes, strongly correlated with the decreased density of mitochondria in CG4 cell processes. Thus besides conferring a protective role against oxidative stress, PV in a cell autonomous fashion additionally affects process’ growth and branching in CG4 cells.</p>
Temperature and fluid pressurization effects on frictional stability of shale faults reactivated by hydraulic fracturing in the Changning Block, Southwest China
<p class="Affiliation"><span>A shale fault reactivated during multi-stage hydraulic fracturing in the Changning block in the Sichuan Basin, southwest China accompanied a cluster of small earthquakes with the largest reaching<span> </span></span><em>M<sub>L</sub></em><span><span> </span>~0.8. We illuminate the underlying mechanisms of fault reactivation through measurements of frictional properties on simulated fault gouge under hydrothermal conditions. Velocity-stepping experiments were performed at a confining pressure of 60<span> </span></span><em>MPa</em><span>, temperatures from 30 to 300<span> </span></span><em>℃</em><span>, pore fluid pressures from 10 to 55<span> </span></span><em>MPa</em><span><span> </span>and shear velocities between 0.122 and 1.22<span> </span></span><em>μm/s</em><span>. Results show that the gouge is frictionally strong with coefficient of friction of 0.6-0.7 across all experimental conditions. At observed<span> </span></span><em>in-situ</em><span><span> </span>pore fluid pressure (30<span> </span></span><em>MPa</em><span>), the slip stability response is characterized by velocity strengthening at temperatures of 30-200<span> </span></span><em>℃</em><span><span> </span>and velocity weakening at temperatures of 250-300<span> </span></span><em>℃</em><span>. Increasing the pore fluid pressure can increase values of (</span><em>a – b</em><span>) at temperatures ≥ 200<span> </span></span><em>℃</em><span>, narrowing the temperature range where velocity weakening occurs. At the<span> </span></span><em>in-situ</em><span><span> </span>temperature (90</span><em>℃</em><span>), the simulated gouge shows only velocity strengthening behavior and aseismic slip at elevated pore fluid pressures, contrary to the observed seismicity. We postulate that the aseismic slip at elevated pore fluid pressures may trigger seismicity by activating adjacent earthquake-prone faults.</span></p>
Data from: Effect of chemical additives on electrokinetic remediation of Cr-contaminated soil coupled with a permeable reactive barrier
Chromium(Cr) contamination in soil, especially Cr(VI) has a serious threat to the environment and human health. The electrokinetic remediation (EKR) is a promising technology to remediate the Cr(VI). Therefore, EKR coupled with a permeable reactive barrier (PRB) was used to treat the Cr(VI) contaminated soil in this study. The CTMAB-Z, a modified zeolite (prepared by cetyl trimethyl ammonium bromide) alone and a mixture of CTMAB-Z and Fe(0) were used as PRB-1 and PRB-2 reactive media, respectively. The effect of chemical enhancers/additives i.e. dl-tartaric acid and tween 80 on EKR of Cr(VI) was also analysed in the contrasting experiments. While, the effects of repair time, voltage gradient and dl-tartaric acid concentration on Cr(VI) remediation were investigated by utilizing multifactor orthogonal experiment which was based on contrasting experiments. The contrasting experiment results showed that the highest Cr(VI) removal rate(66.27%) and leaching efficiency(71.29%) were observed in the experimental group which had dl-tartaric acid and PRB-2. Furthermore, the multifactor orthogonal experiment results had depicted that the highest Cr(VI) removal rate(80.92%) and leaching efficiency(85.25%) were achieved after treating the samples at a voltage gradient of 2.5 v/cm for 8 days in presence of 0.15 M concentration of dl-tartaric acid. This study demonstrated that Cr(VI) remediation through EKR process could be significantly enhanced by the use of PRB and additives.
Data from: Baseline C-reactive protein level and life prognosis in Parkinson disease
Background: C-reactive protein (CRP) is a biomarker of inflammation, and high levels of CRP correlate with vascular death. Chronic inflammation is considered to be involved in neurodegeneration, although there is no evidence linking it with the process of neurodegenerative diseases. Objective: To determine the role of baseline CRP levels in the prognosis of patients with Parkinson disease (PD). Methods: A cohort of 313 patients with a mean age of 69.1 and mean PD duration of 7.9 years was retrospectively followed for a mean observation time of 1,753 days. CRP was measured when patients were not diagnosed with any infections, and levels were repetitively measured to investigate a tendency of "regression to mean." The primary outcome measure was a survival time from study enrollment to death. Results: During the observation period 56 patients died. Baseline CRP was log-linearly associated with a risk of death in PD. Mean survival time was 3,149 (95% confidence interval; 3,009-3,289) days in patients with CRP ≤ 0.8mg/L (lower two thirds) and 2,620 (2,343-2,897) days in those with CRP > 0.8 mg/L (top third, p < 0.001, log-rank test). The adjusted hazard ratio (HR) per two-fold higher CRP concentration for all deaths was 1.29 (1.10-1.52), and after excluding PD-unrelated deaths, such as cancer or stroke, HR was 1.23 (1.01-1.49) (adjusted for age, sex, PD duration, modified Hohen-Yahr stages, MMSE scores, and serum albumin). Conclusions: Baseline CRP concentrations were associated with the risk of death and predicted life prognosis of patients with PD. The associations were independent from PD duration, PD severity, cognitive function, ages, and nutritional conditions, suggesting the possibility that subclinical chronic inflammation is associated with a neurodegenerative process in PD.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.