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1,624 results for “Steroids”
Mapping the glucocorticoid gene regulatory network and alterations that contribute to steroid resistance in childhood acute lymphoblastic leukemia [RNA-seq]
GEO Series GSE175483. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Spatially resolved gene expression of human protate tissue slices treated with steroid hormones for 8 hours
GEO Series GSE159697. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Lung biopsies from asthmatics pre- and post- steroid treatment and from healthy control
GEO Series GSE23611. Homo sapiens. 62 samples. Type: Expression profiling by array.
Bisphenol A-induced renal metabolic disruption: Insights into MAPK-mediated steroid hormone dysregulation from transcriptomic and metabolomic analyses
GEO Series GSE286559. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
The steroid hormone estriol (E3) regulates epigenetic programming of fetal mouse brain and reproductive tract [methylation]
GEO Series GSE199434. Mus musculus. 4 samples. Type: Methylation profiling by high throughput sequencing.
Inhibiting EZH2 complements steroid effects in Duchenne muscular dystrophy
GEO Series GSE288958. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Germline-somatic liaison dictates cancer subtype via de novo steroid biosynthesis
GEO Series GSE293478. Homo sapiens. 29 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional Response to Non-Steroidal Anti-Inflammatory Drugs and Tryptophan Supplementation
GEO Series GSE301033. Mus musculus. 97 samples. Type: Expression profiling by high throughput sequencing.
An animation of the proposed steps for the creation of the first RNA molecule out of steroids.
<p>An animation of the proposed steps for the creation of the first RNA molecule out of steroids.</p>
Data from: Enhancing the steroid sulfatase activity of the arylsulfatase from Pseudomonas aeruginosa
Steroidal sulfate esters play a central role in many physiological processes. They serve as the reservoir for endogenous sex hormones and form a significant fraction of the steroid metabolite pool. The analysis of steroid sulfates is thus essential in fields such as medical science and sports drug testing. Although the direct detection of steroid sulfates can be readily achieved using liquid chromatography-mass spectrometry, many analytical approaches, including gas chromatography-mass spectrometry, are hampered due to the lack of suitable enzymatic or chemical methods for sulfate ester hydrolysis prior to analysis. Enhanced methods of steroid sulfate hydrolysis would expand analytical possibilities for the study of these widely occurring metabolites. The arylsulfatase from Pseudomonas aeruginosa (PaS) is a purified enzyme capable of hydrolysing steroid sulfates. However, this enzyme requires improvement to hydrolytic activity and substrate scope in order to be useful in analytical applications. These improvements were sought by applying semi-rational design to mutate amino acid residues neighbouring the enzyme active site. Mutagenesis was implemented on both single and multiple residue sites. Screening by UPLC-MS was performed to test the steroid sulfate hydrolysis activity of these mutant libraries against testosterone sulfate. This approach revealed the steroid sulfate binding pocket and resulted in three mutants that showed an improvement in catalytic efficiency (Vmax/KM) of more than 150 times that of wild-type PaS. The substrate scope of PaS was expanded and a modest increase in thermostability was observed. Finally, molecular dynamics simulations of enzyme-substrate complexes were used to provide qualitative insight into the structural origin of the observed effects.
Immunophenotypic Alterations in Adult Patients with Steroid-Dependent and Frequently Relapsing Nephrotic Syndrome
<p>Percentages of circulating B and T cell subsets in patient groups and in healthy volunteers</p>
Figure 3 from: Tzankova D, Mateeva A, Mitkov J, Peikova L, Georgieva M (2022) Development and validation of RP-HPLC method for analytical characterization of the anabolic steroid Methenolone acetate in food supplements. Pharmacia 69(1): 151-155. https://doi.org/10.3897/pharmacia.69.e78176
Figure 3 Chromatogram of Methenolone standard solution.
Figure 2 from: Tzankova D, Mateeva A, Mitkov J, Peikova L, Georgieva M (2022) Development and validation of RP-HPLC method for analytical characterization of the anabolic steroid Methenolone acetate in food supplements. Pharmacia 69(1): 151-155. https://doi.org/10.3897/pharmacia.69.e78176
Figure 2 Linearity of the developed RP-HPLC method.
Figure 5 from: Tzankova D, Mateeva A, Mitkov J, Peikova L, Georgieva M (2022) Development and validation of RP-HPLC method for analytical characterization of the anabolic steroid Methenolone acetate in food supplements. Pharmacia 69(1): 151-155. https://doi.org/10.3897/pharmacia.69.e78176
Figure 5 Chromatogram of test solution.
Figure 4 from: Tzankova D, Mateeva A, Mitkov J, Peikova L, Georgieva M (2022) Development and validation of RP-HPLC method for analytical characterization of the anabolic steroid Methenolone acetate in food supplements. Pharmacia 69(1): 151-155. https://doi.org/10.3897/pharmacia.69.e78176
Figure 4 Chromatogram of Methenolone acetate standard solution.
Figure 1 from: Tzankova D, Mateeva A, Mitkov J, Peikova L, Georgieva M (2022) Development and validation of RP-HPLC method for analytical characterization of the anabolic steroid Methenolone acetate in food supplements. Pharmacia 69(1): 151-155. https://doi.org/10.3897/pharmacia.69.e78176
Figure 1 Structure of Methenolone.
Supporting information for 'A Greener Synthesis of the Non-Steroidal Anti-Inflammatory Drug Celecoxib'
<p>Celecoxib PMI and DOZN calculations (.xlsx). Additional PMI calculator web app (.html).</p>
Long-term Use of Takepron on the Prevention of Recurrence of Gastric/Duodenal Ulcer in Patients Receiving Non-steroidal Anti-inflammatory Drugs
ClinicalTrials.gov study NCT02099708. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Treatment of Acute Asthma in ER With Combination of Systemic Steroids and Inhaled Steroids
ClinicalTrials.gov study NCT00397267. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Sex Steroid Replacement Therapy in the Hypogonadism and Transgender Active-Duty Population
ClinicalTrials.gov study NCT06247267. IPD Sharing: NO. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.