Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
2,021
datasets available to search
ShareScore release 0.9.0
Dataset results
2,021 results for “Non-invasive”
Non-invasive approach for evaluation of CTEPH using extracellular vesicle-associated small non-coding RNA
GEO Series GSE138107. Homo sapiens. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Urinary exosome microRNA signatures as a non-invasive prognostic biomarker for prostate cancer
GEO Series GSE173094. Homo sapiens. 42 samples. Type: Expression profiling by RT-PCR.
Single Cell RNA Sequencing of Human Milk-Derived Cells Reveals Sub-Populations of Mammary Epithelial Cells with Molecular Signatures of Progenitor and Mature States: a Novel, Non-invasive Framework fo
GEO Series GSE153889. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Non-invasive prediction of NAFLD severity: a comprehensive, independent validation of previously postulate serum microRNA biomarkers
GEO Series GSE114923. Homo sapiens. 8 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Circulating microRNAs combined with PSA for an accurate and non-invasive prostate cancer detection
GEO Series GSE113234. Homo sapiens. 138 samples. Type: Non-coding RNA profiling by array.
Non-Invasive Detection of Allele-Specific CRISPR-SaCas9-KKH Disruption of TOR1A DYT1 Allele in A Xenograft Mouse Model
GEO Series GSE288087. Mus musculus; Homo sapiens. 42 samples. Type: Other.
CpG Methylation profile of Invasive Prostate Cancer Cells compared to Non-invasive
GEO Series GSE25824. Homo sapiens. 16 samples. Type: Methylation profiling by genome tiling array.
Exosomal MicroRNAs Signature Acts as Efficient Biomarker for Non-Invasive Diagnosis of Gallbladder Carcinoma
GEO Series GSE176159. Homo sapiens. 16 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Identifying urinary RNA as non-invasive biomarkers for progression of chronic kidney disease
GEO Series GSE121978. Homo sapiens. 80 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Data from: Non-invasive stratification of non-alcoholic fatty liver disease by whole-transcriptome cell-free mRNA characterization
<p>Hepatic fibrosis stage is the most important determinant of outcomes in patients with non-alcoholic fatty liver disease (NAFLD). There is an urgent need for non-invasive tests that can accurately stage fibrosis and determine efficacy of interventions. Here we describe a novel cf-mRNA-Sequencing approach that can accurately and reproducibly profile low levels of circulating mRNAs and evaluate the feasibility of developing a cf-mRNA-based NAFLD fibrosis classifier. Using separate discovery and validation cohorts with biopsy-confirmed NAFLD (n=176 and 59, respectively) and healthy subjects (n=23), we performed serum cf-mRNA RNA-Seq profiling. Differential expression analysis identified 2498 dysregulated genes between NAFLD and healthy subjects and 134 fibrosis-associated genes in NAFLD patients. Comparison between cf-mRNA and liver tissues transcripts revealed significant overlap of fibrosis associated genes and pathways indicating that the circulating cf-mRNA transcriptome reflects molecular changes in the livers of NAFLD patients. In particular, metabolic and immune pathways reflective of known underlying steatosis and inflammation were highly dysregulated in the cf-mRNA profile of patients with advanced fibrosis. Finally, we used an elastic net ordinal logistic model to develop a classifier that predicts clinically significant fibrosis (F2-4). In an independent cohort, the cf-mRNA classifier was able to identify 50% of patients with at least 90% probability of clinically significant fibrosis. We demonstrate<b> </b>a<b> </b>novel and robust cf-mRNA-based RNA-Seq platform for non-invasive identification of diverse hepatic molecular disruptions and for fibrosis staging with promising potential for clinical trials and clinical practice.</p>
Data from: Genetic identification of Iberian rodent species using both mitochondrial and nuclear loci: application to non-invasive sampling
Species identification through non-invasive sampling is increasingly used in animal conservation genetics, given that it obviates the need to handle free-living individuals. Non-invasive sampling is particularly valuable for elusive and small species such as rodents. Although rodents are not usually assumed to be the most obvious target for conservation, of the 21 species or near-species present in Iberia, three are considered endangered and declining while several others are poorly studied. Here we develop a genetic tool for identifying all rodent species in Iberia by non-invasive genetic sampling. To achieve this purpose we selected one mitochondrial gene (cytochrome b – cyt-b) and one nuclear gene (interphotoreceptor retinoid-binding protein – IRBP), which we first sequenced using tissue samples. Both genes allow for the phylogenetic distinction of all species except the sibling species Microtus lusitanicus and M. duodecimcostatus. Overall, cyt-b showed higher resolution than IRBP, revealing a clear barcoding gap. To allow these markers to be applied to non-invasive samples, we selected a short highly-diagnostic fragment from each gene, which we used to obtain sequences from faeces and bones from owl pellets. Amplification success for the cyt-b and IRBP fragment was 85% and 43% in faecal and 88% and 64% in owl-pellet DNA extractions, respectively. The method allows the unambiguous identification of the great majority of Iberian rodent species from non-invasive samples, with application in studies of distribution, spatial ecology and population dynamics, and for conservation.
Evaluation of non-invasive dsRNA delivery methods for the development of RNA interference in the Asian tiger mosquito Aedes albopictus
<p>The Asian tiger mosquito Aedes albopictusis one of the most invasive species and an efficient vector of<br>several pathogens. RNA interference (RNAi) has been proposed as an alternative method to control<br>mosquito populations by silencing the expression of genes that are essential for their survival. However,<br>the optimal delivery method for dsRNAs to enhance an optimal RNAi remains elusive and comparative<br>studies are lacking. We have, therefore, compared the efficiency of three non-invasive delivery methods to<br>mosquito larvae: soaking, rehydration and nanoparticle ingestion. Each method was tested separately on<br>four genes predicted to code non-essential proteins (i.e. collagenase-like, kynurenine 3-monooxygenaselike, yellow-like and venom serine protease-like) in order to be able to compare the importance of gene<br>knock-down.<br>All tested methods successfully downregulated mosquito gene expression. However, silencing efficiency<br>strongly varies among methods and genes. Silencing (95.1%) was higher for Kynurenine 3-<br>monooxygenase-like with rehydration and nanoparticle ingestion (61.1%). For the Venom serine proteaselike, the most efficient silencing was observed with soaking (74.5%) and rehydration (34%). In contrast,<br>the selected methods are inefficient to silence the other genes. Our findings also indicate that gene copy<br>numbers, transcript sizes and GC content correlate with the silencing efficiency.<br>From our results, rehydration was the most specific and efficient methods to specifically knock-down<br>gene expression in Ae. albopictus larvae. Nevertheless, considering the observed variability of efficiency is<br>gene-dependent, our results also point at the necessity to test and optimize diverse dsRNA delivery<br>approaches to achieve a maximal RNAi efficiency.</p>
Non-invasive 3D visualization of the sponge-inhabiting barnacle Acasta sulcata (Crustacea: Cirripedia: Balanomorpha) from the Moluccas, Indonesia
<p>We present a digital reconstruction (video) of non invasive microCT scans of barnacle specimens (<em>Acasta sulcata</em>; catalogue number MZB Cru Cir 185, Indonesia) embedded in their sponge host (<em>Spongia</em> sp.) from the Indonesian island Saparua, Moluccas (for details see Pitriana et al. 2020; doi: <a href="http://dx.doi.org/10.14203/treubia.v47i2.3968">10.14203/treubia.v47i2.3968</a>). </p> <p>The sponge specimen, which was supposed to host barnacles, was subjected to micro-tomographic analysis at the Museum für Naturkunde Berlin, using a Phoenix nanotom X-rays tube at 90 kV and 150 µA, generating 1440 projections. The specimen was fixed with foam in a sealed plastic tube in an ethanol-saturated atmosphere. Cone beam reconstruction was performed using the phoenix/x-ray datos/x version 2.3.3 software (GE Sensing and Inspection Technologies GmbH). Effective voxel size, i.e. resolution in three-dimensional space, is 13.33 µm. Data were visualized in VG Studio Max, version 3.1. In the video, barnacles are shown as an isosurface in red color, the surrounding sponge tissue as volume rendering in grey color (original length of sponge host 10 cm; length of barnacles approx. 2.5 mm).</p> <p>This study is part of Pipit Pitriana's PhD project (<a href="https://refubium.fu-berlin.de/handle/fub188/29031">https://refubium.fu-berlin.de/handle/fub188/29031</a>) funded by the Ministry of Research, Technology and Higher Education, the Republic of Indonesia within the Program for Research and Innovation in Science and Technology (RISET-Pro), World Bank Loan No. 8245-ID. We thank Kristin Mahlow and Johannes Müller for their support at the MfN Berlin and Frank Riedel (FU Berlin) for his general support.</p>
Data from: Does non-invasive brain stimulation modify hand dexterity? Protocol for a systematic review and meta-analysis
[No abstract entered]
Figure 2 from: Nader M, El Indary S, Abi Salloum B, Abou Dagher M (2011) Combining non-invasive methods for the rapid assessment of mammalian richness in a transectquadrat survey scheme – Case Study of the Horsh Ehden Nature Reserve, North Lebanon. ZooKeys 119: 63-71. https://doi.org/10.3897/zookeys.119.1040
Figure 2 - Quadrat travel route.
Figure 1 from: Nader M, El Indary S, Abi Salloum B, Abou Dagher M (2011) Combining non-invasive methods for the rapid assessment of mammalian richness in a transectquadrat survey scheme – Case Study of the Horsh Ehden Nature Reserve, North Lebanon. ZooKeys 119: 63-71. https://doi.org/10.3897/zookeys.119.1040
Figure 1 - Quadrats and gradient slopes; Blue circle indicates the forested area.
Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure
ClinicalTrials.gov study NCT00777725. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study of PET Adapted Therapy and Non-invasive Monitoring for Previously Untreated Limited Stage Diffuse Large B Cell Lymphoma
ClinicalTrials.gov study NCT03758989. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Non-Invasive Evaluation of Transplant Kidney Using OCT
ClinicalTrials.gov study NCT02084966. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Non-invasive TB Triage and Patient Mapping Platform Using Breath Via Low-Cost Titanium Dioxide Nanotube Sensor
ClinicalTrials.gov study NCT02681445. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.