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126,115 results for “Patients”
Hemostatic system in Takotsubo patients at long-term follow-up: A hidden activation?
<p>This record contains raw data related to the article “Hemostatic system in Takotsubo patients at long-term follow-up: A hidden activation?”</p> <p><strong>Background: </strong>Takotsubo cardiomyopathy (TTS) has long been considered a benign condition, despite recurrent events and long-term adverse outcomes are often reported. Endothelial damage, blood hyperviscosity, and platelet activation described in acute phase persist in long-term follow-up; however, TTS pathophysiology is still not fully understood. Here, we explored the hemostatic system at a median of 3.1 years after TTS to uncover additional long-lasting changes in these patients.</p> <p><strong>Methods: </strong>We assessed hemostatic parameters in women with TTS (n = 23) or coronary artery disease (CAD; n = 31) and in control women (n = 26) age-matched, by thromboelastographic analysis, prothrombin time (PT) and partial thromboplastin time (aPTT) coagulation assays and microparticle exposing Tissue Factor (MP-TF). Functional fibrinogen and fibrin polymerization were analyzed by Clauss method and spectrophotometry, respectively. Platelet reactivity was evaluated by light transmission aggregometry, whereas plasminogen activator inhibitor-1 (PAI-1) and brain-derived neurotrophic factor (BDNF) were measured by ELISA kit.</p> <p><strong>Results: </strong>Compared with control subjects, TTS patients exhibit an accelerated clot formation, higher percentage of fibrin polymerization and higher PAI-1 levels. Compared with CAD, TTS patients showed sustained residual platelet activation but decreased functional fibrinogen, fibrin polymerization and MP-TF levels, prolonged aPTT and a marked BDNF increase.</p> <p><strong>Conclusions: </strong>The long-term activation of hemostatic system observed in TTS patients compared to control subjects suggests a persistent humoral abnormality that may be related to the propensity for TTS recurrence. The higher residual platelet activity observed in TTS than in CAD patients invites investigation on TTS-tailored antiplatelet therapy potentially needed to prevent TTS adverse outcomes.</p>
Association Between Change in The Peripheral Biomarkers of Inflammation, Astrocyte Activation, and Neuroprotection at One Week of Critical Illness and Hospital Mortality in Patients with Delirium: A Prospective Cohort Study
<p>Dataset for the following publication: Association Between Change in The Peripheral Biomarkers of Inflammation, Astrocyte Activation, and Neuroprotection at One Week of Critical Illness and Hospital Mortality in Patients with Delirium: A Prospective Cohort Study</p>
Study group charasteristics and sequencing data of patients with essential thrombocythemia and polycythemia vera
<p><span>Polycythemia vera (PV) and essential thrombocythemia (ET) are diseases driven by canonical mutations in <em>JAK2, CALR</em>, or <em>MPL </em>gene. Previous studies revealed that in addition to driver mutations, patients with PV and ET can harbor other mutations in various genes, with no established impact on disease phenotype. We hypothesized that the molecular profile of patients with PV and ET is dynamic throughout the disease. In this study we performed 37-gene targeted next-generation sequencing panel on the DNA samples collected from 49 study participants in two time points, separated by 78-141 months. We identified 78 variants across 37 analyzed genes in the study population. By analyzing the change in variant allele frequencies (VAFs) and revealing the acquisition of new mutations during the disease, we confirmed the dynamic nature of molecular profile of patients with PV and ET. We found connections of specific variants with the development of secondary myelofibrosis, thrombotic events, and response to treatment. We confronted our results with existing conventional and mutation-enhanced prognostic systems, showing the limited utility of available prognostic tools. Results of this study underline the significance of repeated molecular testing in patients with PV and ET and indicate the need for further research within this field to better understand the disease and improve available prognostic tools.</span></p>
Single Cell RNA sequencing data of ADT treated Prostate cancer patients
<p>The data was generated from a study that was conducted according to guidelines approved by the Review Board at the University of Texas Southwestern Medical Center. We procured patient biopsy samples from two distinct studies. The first is titled "Tissue Collection and Results Gathering for Radiotherapy Patients & Healthy Individuals" (STU 072010-098), and the second is a Phase I Clinical Study on Stereotactic Ablative Radiotherapy (SABR) for Pelvic and Prostate Areas in High-Risk Prostate Cancer Patients (STU062014-027). The single-cell RNA sequencing (scRNA-seq) took place in Dr. Douglas Strand's laboratory, adhering to the method outlined in Henry et al<sup>1</sup>. We used a 1-hour treatment with 5mg/ml of collagenase type I, 10mM of ROCK inhibitor, and 1mg of DNase. Barcode labeling for 3' GEX was done using a 10X machine, and the sequencing process utilized an Illumina NextSeq 500 device.</p> <p> </p> <p>1. Henry, G. H., Malewska, A., Joseph, D. B., Malladi, V. S., Lee, J., Torrealba, J., ... & Strand, D. W. (2018). A cellular anatomy of the normal adult human prostate and prostatic urethra. <em>Cell reports</em>, <em>25</em>(12), 3530-3542.</p>
Quantitative susceptibility-based MRI radiomic features in patients with multiple sclerosis and healthy controls
<p>This dataset provides access to radiomic features of brain MR susceptibility-based images (QSM). Specifically, a cohort of 151 subjects, mixed of patients with multiple sclerosis (121) and healthy controls (30) was analysed, studying the Normal Appearing White Matter (NAWM) and NAWM tracts (e.g. corticospinal tract and optic radiation). Robustness analysis of those imaging descriptors can be found in Fiscone et al., <em>Assessing robustness of quantitative susceptibility-based MRI radiomic features in patients with multiple sclerosis. </em></p> <p>In the .zip folder, instructions about the organization of the dataset can be found. Together with the data, the code used to assess the reliability of those features is available. </p>
Data for A Far-Red Fluorescent Probe to Visualize Staphylococcus aureus in Patient Samples
<p>Raw and processed data supporting the manuscript "A Far-Red Fluorescent Probe to Visualize <em>Staphylococcus aureus</em> in Patient Samples"</p>
Effectiveness of self-management of medication and self-monitoring of blood pressure, diet, and physical exercise on blood pressure in patients with poorly controlled hypertension (MEDICHY study): randomized and controlled trial
<p>Dataset study medichy ISRCTN144433778</p>
The Magee 3 Equation Predicts Favorable Pathologic Response to Neoadjuvant Endocrine Therapy in Breast Cancer Patients
<p><strong>Supplementary Figure 1: </strong>Comparison between ROC curves of ME1, ME2, ME3, and MEm scores in a sample of breast cancer patients undergoing neoadjuvant endocrine therapy.</p> <p><strong>Supplementary Figure 2: </strong>ROC curves with their respective confidence intervals and AUC values in the sample of breast cancer patients, excluding those with clinical stage IA tumors. A: ME1. B: ME2. C: ME3. D: MEm.</p> <p><strong>Supplementary Figure 3:</strong> Comparison between ROC curves of ME1, ME2, ME3, and MEm scores in the sample of breast cancer patients undergoing neoadjuvant endocrine therapy (excluding those with clinical stage IA tumors).</p> <p> </p>
High CD8 + / FOXP3+ Ratio is Significantly Associated with Primary Endocrine Therapy Resistance Occurrence in Locally Advanced Luminal B Her-2 Negative Breast Cancer Patients
<p>High CD8 + / FOXP3+ Ratio is Significantly Associated with Primary Endocrine Therapy Resistance Occurrence in Locally Advanced Luminal B Her-2 Negative Breast Cancer Patients</p>
The Prognostic Value of COX-2 in Predicting Metastasis of Patients with Colorectal Cancer: A systematic review and meta analysis.
<p>The Prognostic Value of COX-2 in Predicting Metastasis of Patients with Colorectal Cancer: A systematic review and meta analysis.</p>
Risk-reducing bilateral salpingo-oophorectomy in HBOC patients at urban public hospital
<p>Data collected from a diverse patient population at an urban, public hospital with Hereditary Breast and Ovarian Cancer Syndromes and their utilization of risk reducing bilateral salpingo-oophorectomy. </p>
Patient-Derived Tumor Organoid and Fibroblast Assembloid Models for interrogation of the tumor microenvironment in Esophageal Adenocarcinoma
<p>This repository contains original microscopy data from the Sharpe et al. paper, "Patient-Derived Tumor Organoid and Fibroblast Assembloid Models for interrogation of the tumor microenvironment in Esophageal Adenocarcinoma" in Cell Reports Methods 2024.</p> <p>All whole slide images were obtained using an LM dotSlide slide scanning microscope in Olympus .vsi format and can be opened using the BioFormats library (for example, in QuPath). Wholemount immunofluorescent stains were imaged on a Leica SP8 laser-scanning confocal microscope and are presented as .IMS files, which allows for visualization and further analysis of the 3D data in Imaris (Oxford Instruments).</p> <p>Data are arranged in subfolders based on the figure they came from (Figures 1-4).</p>
Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease
ClinicalTrials.gov study NCT04332991. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Evaluating QTc, PK, Safety of Gemtuzumab Ozogamicin (GO) in Patients With CD33+ R/R AML
ClinicalTrials.gov study NCT03727750. IPD Sharing: YES. Countries: 6. Publications: 1.
Use of Dapagliflozin to Reduce Burden of Atrial Fibrillation in Patients Undergoing Catheter Ablation of Symptomatic Atrial Fibrillation
ClinicalTrials.gov study NCT04792190. IPD Sharing: NO. Countries: 1. Publications: 42.
Efficacy/Safety of Octreotide Acetate in Patients With Uncontrolled Acromegaly
ClinicalTrials.gov study NCT00372697. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Early Antibiotics After Aspiration in ICU Patients
ClinicalTrials.gov study NCT05079620. IPD Sharing: NO. Countries: 1. Publications: 12.
Exercise Application in the Treatment of Patients With Subacromial Pain Syndrome
ClinicalTrials.gov study NCT02695524. IPD Sharing: YES. Countries: 1. Publications: 15.
Pharmacodynamics and Pharmacokinetics of Empagliflozin and Torasemide in Patients With Type 2 Diabetes
ClinicalTrials.gov study NCT01276288. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Randomized Controlled Trial of Talc Instillation In Addition To Daily Drainage Through a Tunneled Pleural Catheter to Improve Rates of Outpatient Pleurodesis in Patients With Malignant Pleural Effusio
ClinicalTrials.gov study NCT04792970. IPD Sharing: NO. Countries: 1. Publications: 2.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.