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1,723 results for “Reactivation”
Data from: Downregulation of autophagy is associated with severe ischemia-reperfusion-induced acute kidney injury in overexpressing C-reactive protein mice
C-reactive protein (CRP), was recently reported to be closely associated with poor renal function in patients with acute kidney injury (AKI), but whether CRP is pathogenic or a mere biomarker in AKI remains largely unclear. Impaired autophagy is known to exacerbate renal ischemia-reperfusion injury (IRI). We examined whether the pathogenic role of CRP in AKI is associated with reduction of autophagy. We mated transgenic rabbit CRP over-expressing mice (Tg-CRP) with two autophagy reporter mouse lines, Tg-GFP-LC3 mice (LC3) and Tg-RFP-GFP-LC3 mice (RG-LC3) respectively to generate Tg-CRP-GFP-LC3 mice (PLC3) and Tg-CRP-RFP-GFP-LC3 mice (PRG-LC3). AKI was induced by IRI. Compared with LC3 mice, PLC3 mice developed more severe kidney damage after IRI. Renal tubules were isolated from LC3 mice at baseline for primary culture. OKP cells were transiently transfected with GFP-LC3 plasmid. CRP addition exacerbated lactate dehydrogenase release from both cell types. Immunoblots showed lower LC-3 II/I ratios and higher levels of p62, markers of reduced autophagy flux, in the kidneys of PLC3 mice compared to LC3 mice after IRI, and in primary cultured renal tubules and OKP cells treated with CRP and H2O2 compared to H2O2 alone. Immunohistochemistry showed much fewer LC-3 punctae, and electron microscopy showed fewer autophagosomes in kidneys of PLC3 mice compared to LC3 mice after IRI. Similarly, CRP addition reduced GFP-LC3 punctae induced by H2O2 in primary cultured proximal tubules and in GFP-LC3 plasmid transfected OKP cells. Rapamycin, an autophagy inducer, rescued impaired autophagy and reduced renal injury in vivo. In summary, it was suggested that CRP be more than mere biomarker in AKI, and render the kidney more susceptible to ischemic/oxidative injury, which is associated with down-regulating autophagy flux.
Dataset related to article "Optimal Predictors of Postoperative Complications After Gastrectomy: Results from the Procalcitonin and C-reactive Protein for the Early Diagnosis of Anastomotic Leakage in Esophagogastric Surgery (PEDALES) Study"
<p>This record contains raw data related to article "Optimal Predictors of Postoperative Complications After Gastrectomy: Results from the Procalcitonin and C-reactive Protein for the Early Diagnosis of Anastomotic Leakage in Esophagogastric Surgery (PEDALES) Study"</p><p><strong>Abstract</strong></p><p><strong>Background: </strong>The aim of this study was to define whether procalcitonin (PCT) is an earlier and more accurate predictor than C-reactive protein (CRP) for anastomotic leakage (AL) and major infective complications (MICs).</p><p><strong>Methods: </strong>This was a prospective multicentric observational study conducted in three Italian centers, including all patients undergoing gastrectomy from May 2016 to April 2021. The endpoint was the assessment of the discrimination and accuracy achieved by the PCT and CRP values measured from POD1 to POD7 for predicting the occurrence of AL and MICs. Accuracy was assessed by calculating the area under the receiver operating curve (AUROC) values and Youden's statistics. Two charts were created for risk stratification during the postoperative course.</p><p><strong>Results: </strong>The rate of AL was 4.6%, with a median day of occurrence on POD5 (range 3-26). The overall rate of major infective complications was 19.9%, with a median day of occurrence on POD6 (range 2-30). PCT showed a significant association with AL on POD6 and POD7 and a significant association with MICs on POD2, while CRP values showed a significant association with AL on POD4 and a significant association with MICs on POD1. No difference in the prediction of AL was observed between PCT and CRP, while CRP was found to be a superior predictor of major infective complications on POD5 (p = 0.024) and POD7 (p = 0.035).</p><p><strong>Conclusions: </strong>PCT was not superior to CRP as an early predictor of AL and major infective complications after gastrectomy. CRP should be used as the reference screening postoperative marker.</p>
Tailoring the reaction path: External crack initiation in reactive Al/Ni Multilayers
<p>This are the main raw data and derived data for the publication "Tailoring the reaction path: External crack initiation in reactive Al/Ni Multilayers".</p> <p>Abstract:</p> <p>The influence of intentionally externally induced cracks in reactive Al/Ni multilayer systems is investigated. These cracks affect the reaction dynamics and enable tailoring of the reaction path and the overall velocity of the reaction front. The influence of layer variations onto mechanical crack formation and resulting reaction behavior are investigated. High-speed camera imaging shows the meandering propagation of the reaction front along the crack paths. Therefore, the mechanical cracking process significantly changes the total velocity of the reaction front and thus offers a possibility to control the self-propagating high-temperature synthesis process. It is shown that the phase formation remains unaffected despite the applied strains and cracks. This favorable stability in phase formation ensures predictability and provides insight into the adaptation of RMS for precision applications in joints. The results expand the understanding of mechanical cracking as a tool to influence high temperature synthesis in reactive multilayer coatings and provide an opportunity to expand the range of applications.</p>
Evaluating the utility of a high throughput thiol-containing fluorescent probe to screen for reactivity: A case study with the Tox21 library.
<p>Data underlying manuscript Patlewicz G, Paul-Friedman K, Houck K, Zhang L, Huang R, Xia M, Brown J, Simmons SO. Evaluating the utility of a high throughput thiol-containing fluorescent probe to screen for reactivity: A case study with the Tox21 library. Computational Toxicology https://doi.org/10.1016/j.comtox.2023.100271</p>
Gram reactivity of bacteria virulence factor effects for polymyxin
<p class="MsoNoSpacing"><span>Research was to study the bacitracin effects as a polypeptide on prokaryote plants. The research question can bacitracin be used to differentiate Streptococcus pyogenes from other step bacteria with S. pyogenes being reactive to bacitracin and others resistant. The method involved using polymyxins with and without bacitracin for treatment of Gram-negative bacterial infections. This involved disintegration of bacterial cell membrane. The results showed the test differentiated and prevented infectants similar to the initial synopsis in plant. The detection of bacterial sepsis at the initial stage was challenging because of the nature of traits and difficulty in culturing infectiosn and lack of sufficient material. The polymyxins was not absorbed in the extracellular region of the plant. This was then supplied through the cytoplasm. It concluded the amount necessary for detection of Streptococcus pyogenes was between 0.5 μg/mL to 16 μg/mL. The polymyxins with bacitracin disrupted the dephosphorylaton of cell exterior of the membrane.</span></p>
Reactive Transport in Heterogeneous Porous Media Under Different Peclet Numbers
<p>In our recent paper “Reactive Transport in Heterogeneous Porous Media Under Different Peclet Numbers“, we study the synergistic effects of the Peclet number and the length scale of medium heterogeneity on the evolution of bimolecular reactive transport between mobile and immobile species. We performed a suite of numerical simulations at the Darcy scale that quantify the instantaneous, irreversible bimolecular reaction , under various transport conditions (Peclet numbers) and porous media configurations (correlation lengths).</p> <p> </p> <p><strong>Numerical Methods</strong></p> <p>We used the following steps to obtain the results:</p> <p>1. Generation of the hydraulic conductivity fields – we used a widely tested sequential Gaussian simulator (Gómez-Hernández & Journel, 1993). The software is written in C and available to download via <a href="https://wiki.52north.org/AI_GEOSTATS/SWGCOSIM3D">https://wiki.52north.org/AI_GEOSTATS/SWGCOSIM3D</a>. In the file ‘real20.mat’, we show an example of the generated 20 realizations, from the software, for <span class="math-tex">\(\ell\)</span>=1 ,<span class="math-tex">\(\sigma^2\)</span>=1. </p> <p>2. Determination of the flow field – we solve the Darcy equation (for each of the hydraulic conductivity fields), using an open-source code MRST (Lie, 2016). The software is available to download via <a href="https://www.sintef.no/projectweb/mrst/">https://www.sintef.no/projectweb/mrst/</a>. In the file ‘real20_solutions.mat’, we show the flow field solutions (for the different realizations from ‘real20.mat’) under different Peclet numbers. For each realization and Peclet, we store the solution of the velocity components (first column), the velocity magnitude (second column) and the hydraulic conductivity field (third column).</p> <p>3. Chemical transport – was modeled through the Langevin equation, where movement by advection and diffusion were taken into account. Chemical reaction between the different chemical species was modeled via the reaction-radius approach (Edery, Porta, Guadagnini, Scher, & Berkowitz, 2016).</p> <p><br> <strong>Results</strong></p> <p>The data of the published figures can be download from the following files:</p> <p><strong>Fig2.txt</strong> -- processed simulation results shown in Figure 2.</p> <p><strong>Fig3.txt</strong> -- processed simulation results shown in Figure 3a,b.</p> <p><strong>Fig4.txt </strong>-- processed simulation results shown in Figure 4.</p> <p><strong>Fig5.txt </strong>-- processed simulation results shown in Figure 5.</p> <p><strong>FigS1.png </strong>-- First and second statistical moments of the generated conductivity fields, for different correlation lengths. The left axis displays the first moment of the generated fields (ln(K)), and the right axis shows the second moment (ln)). The small circles represent individual realizations, and the large circles indicate the mean value among realizations.</p> <p><strong>FigS2.png </strong>-- Sensitivity analysis of the power law parameters (a) and (b) (see equation (1) in the main text), among realizations; mean values are represented by gray circles, and the standard deviations by the vertical black lines. (c) and (d) show the standard deviations of (a) and (b), respectively, in percentage. Note that among the different realizations, the standard deviation does not exceed 3%. </p> <p> </p> <p><strong>References</strong></p> <p>[1] Edery, Y., Porta, G. M., Guadagnini, A., Scher, H., & Berkowitz, B. (2016). Characterization of Bimolecular Reactive Transport in Heterogeneous Porous Media. Transport in Porous Media. https://doi.org/10.1007/s11242-016-0684-0</p> <p>[2] Gómez-Hernández, J. J., & Journel, A. G. (1993). Joint Sequential Simulation of MultiGaussian Fields. https://doi.org/10.1007/978-94-011-1739-5_8</p> <p>[3] Lie, K.-A. (2016). User Guide for the MATLAB Reservoir Simulation Toolbox (MRST). In A. Soares (Ed.), An Introduction to Reservoir Simulation Using MATLAB. Oslo, Norway: SINTEF ICT, Department of Applied Mathematics. </p> <p> </p> <p> </p>
Alkyne-functionalized cyclooctyne on Si(001) – reactivity studies and surface bonding from an energy decomposition analysis perspective
<p>The reactivity and bonding of an ethinyl-functionalized cyclooctyne on Si(001) is studied by means of density functional theory. This system is promising for the organic functionalization of semiconductors. Singly bonded adsorption structures are obtained by [2+2] cycloaddition reactions of the cyclooctyne or ethinyl group with the Si(001) surface. A thermodynamic preference for an adsorption with the cyclooctyne group in on-top position is found and traced back to minimal structural deformation of adsorbate and surface with the help of the energy decomposition analysis for extended systems (pEDA). Starting from singly bonded structures a plethora of reaction paths describing conformer changes and consecutive reactions with the surface are discussed. Strongly exothermic and exergonic reactions to doubly bonded structures are presented, while small reaction barriers highlight the high reactivity of the studied organic molecule on the Si(001) surface. Dynamic aspects of the competitive bonding of the functional groups are addressed by ab initio molecular dynamics calculations. Several trajectories to doubly bonded structures are obtained in agreement to calculations using the nudged-elastic band approach. However, our findings are in disagreement with experimental observations of a selective adsorption by the cyclooctyne moiety, which is critically discussed.</p>
C-reactive Protein，Homocysteine，Postoperative Delirium
ClinicalTrials.gov study NCT05164965. IPD Sharing: NO. Countries: 1. Publications: 0.
Thalidomide Prevention or Treatment of Camrelizumab-induced Reactive Cutaneous Capillary Endothelial Proliferation (RCCEP)
ClinicalTrials.gov study NCT06231680. IPD Sharing: NO. Countries: 1. Publications: 0.
Effectiveness of the American Lung Association Reactive Anti-Smoking Telephone Help Line in Illinois
ClinicalTrials.gov study NCT00749151. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Aripiprazole Effects on Alcohol Reactivity and Consumption
ClinicalTrials.gov study NCT00183235. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Reactivation of Inactive Blood Donors
ClinicalTrials.gov study NCT03366441. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Evaluation of Reactive Oxygen Metabolites in the Value of COPD
ClinicalTrials.gov study NCT02297633. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Autologous T-cells Genetically Engineered to Express Receptors Reactive Against KRAS Mutations in Conjunction With a Vaccine Directed Against These Antigens in Participants With Metastatic Cancer
ClinicalTrials.gov study NCT06253520. IPD Sharing: YES. Countries: 1. Publications: 0.
Does the Measurement of Pupillary Reactivity by an Automated Pupillometer Determine the Effectiveness of Local Anesthesia Under General Anesthesia?
ClinicalTrials.gov study NCT01685645. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Mechanism and Dynamics of Bronchial Hyper-reactivity to Methacholine in Distal Airway on Obese Patients With Asthma
ClinicalTrials.gov study NCT03102749. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Cytomegalovirus Reactivation in ICU Patients Requiring Prolong Mechanical Ventilation
ClinicalTrials.gov study NCT06520605. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Changes in the Immune Response and Skin Reactivity of Grass Pollen Allergic Patients Treated With ALK Grass Tablets
ClinicalTrials.gov study NCT00413556. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Burden of Cytomegalovirus Reactivation in Pediatric Patients After Allogeneic Hematopoietic Stem Cell Transplantation
ClinicalTrials.gov study NCT06916195. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effect of Ezetimibe on Flow-mediated Brachial Artery Reactivity in Healthy Subjects
ClinicalTrials.gov study NCT00376246. IPD Sharing: Not stated. Countries: 0. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.