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FIGURE 6 in A new species of the ghost shrimp genus Callianassa Leach, 1814 (Decapoda Axiidea: Callianassidae) from Wakasa Bay, western Japan: the first representative of the genus from the Pacific region
FIGURE 6. Maximum likelihood (ML) phylogenetic tree of Callianassa ogurai n. sp. and other callianassid species based on 486 bp of the mitochondrial 16S rRNA gene. Bootstrap values (≥ 50%) are shown. GenBank/EMBL/DDBJ accession numbers are indicated for each sequence.
FIGURE 3.Callianassa ogurai n in A new species of the ghost shrimp genus Callianassa Leach, 1814 (Decapoda Axiidea: Callianassidae) from Wakasa Bay, western Japan: the first representative of the genus from the Pacific region
FIGURE 3.Callianassa ogurai n. sp., paratype male (cl 4.5 mm), CBM-ZC 17095: A, right major cheliped, lateral view; B, same, mesial view. Paratype female (cl 6.4 mm), CBM-ZC 17094: C, left major cheliped, lateral view; D, same, mesial view; E, right minor cheliped, lateral view.
FIGURE 2. Callianassa ogurai n in A new species of the ghost shrimp genus Callianassa Leach, 1814 (Decapoda Axiidea: Callianassidae) from Wakasa Bay, western Japan: the first representative of the genus from the Pacific region
FIGURE 2. Callianassa ogurai n. sp., holotype, male (cl 5.7 mm), CBM-ZC 17093: A, left major cheliped, lateral view; B, left major cheliped, mesial view; C, right minor cheliped, lateral view; D, right minor cheliped, merus to chela, mesial view; E, proximal spines on lower margin of ischium of right minor cheliped.
FIGURE 1. Callianassa ogurai n in A new species of the ghost shrimp genus Callianassa Leach, 1814 (Decapoda Axiidea: Callianassidae) from Wakasa Bay, western Japan: the first representative of the genus from the Pacific region
FIGURE 1. Callianassa ogurai n. sp., holotype, male (cl 5.7 mm), CBM-ZC 17093: A, carapace and cephalic appendages, lateral view; B, pleon, telson, and pleonal appendages, lateral view; C, carapace and cephalic appendages, dorsal view (left antennular flagella and antenna omitted); D, pleomeres 1–6, dorsal view; E, telson and left uropod, dorsal view (perpendicular); F, lower margin of telson, dorsal view.
CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy
<p>Tumors exploit numerous immune checkpoints including those deployed by myeloid cells to curtail anti-tumor immunity. Here, we show that the C-type lectin receptor CLEC-1 expressed by myeloid cells senses dead cells killed by programmed necrosis. Moreover, we identified TRIM21 as an endogenous ligand over-expressed in various cancers. Interestingly, we observed that in mice CLEC-1 blockade combined with chemotherapy to prolong survival in tumor models. Loss of CLEC-1 reduced the accumulation of immunosuppressive myeloid cells in tumors and invigorated the activation state of dendritic cells (DCs), thereby increasing T cell responses. Mechanistically, we found that the absence of CLEC-1 increased the cross-presentation of dead-cell associated antigens by conventional type-1 DCs. Importantly, we identified anti-human CLEC-1 antagonist antibodies able to enhance anti-tumor immunity in CLEC-1 humanized mice. Altogether, our results demonstrate that CLEC-1 acts as an immune checkpoint in myeloid cells and support CLEC-1 as a novel target for cancer immunotherapy.</p>
FIGURES 4–8 in First fossil representatives of Pharaxonothinae Crowson (Coleoptera: Erotylidae): indirect evidence for cycads existence in Baltic amber forest
FIGURES 4–8. Cycadophila mumia sp. nov.: 4—habitus, dorso-lateral view, paratype; 5—details of forebody, ventral view, holotype; 6—head and pronotum, dorso-lateral view, paratype; 7—antenna, paratype; 8—protibia and tarsus, paratype. Not reproduced to the same scale.
FIGURES 1–3 in First fossil representatives of Pharaxonothinae Crowson (Coleoptera: Erotylidae): indirect evidence for cycads existence in Baltic amber forest
FIGURES 1–3. Cycadophila mumia sp. nov., holotype, habitus: 1—dorsal view; 2—ventral view; 3—lateral view. Scale bar = 1 mm.
FIGURES 10–11 in First fossil representatives of Pharaxonothinae Crowson (Coleoptera: Erotylidae): indirect evidence for cycads existence in Baltic amber forest
FIGURES 10–11. Undescribed representative of Pharaxonothinae in Baltic amber, specimen No. 578-1 [CCHH]: 10—habitus, dorso-lateral view; 11—habitus, lateral view. Scale bar = 1 mm.
Text - fig. 4 — Femur of Albertosaurus cf. A. lancensis (LACM 23845) in anterior aspect. Diagonal lines indicate broken surfaces. Bar represents 10 cm. in An albertosaur from the Hell Creek formation of Montana
Text - fig. 4 — Femur of Albertosaurus cf. A. lancensis (LACM 23845) in anterior aspect. Diagonal lines indicate broken surfaces. Bar represents 10 cm.
FIGURE 9. Adult male Megophrys kuatunensis holotype, AMNH 30126 in The Vietnamese population of Megophrys kuatunensis (Amphibia: Megophryidae) represents a new species of Asian horned frog from Vietnam and southern China
FIGURE 9. Adult male Megophrys kuatunensis holotype, AMNH 30126. (A) Palmar surface of right hand, and (B) plantar surface of right foot. Scale bar 5.0 mm.
FIGURE 4 in The Vietnamese population of Megophrys kuatunensis (Amphibia: Megophryidae) represents a new species of Asian horned frog from Vietnam and southern China
FIGURE 4. Megophrys rubrimera sp. nov. in life. (A) Dorsal view of holotype VNMN 2017.002, (B) dorsolateral view of paratype AMS R177679, (C) lateral view of referred specimen HNLP2016062200001, (D) ventral view of holotype VNMN 2017.002, (E) ventral view of paratype AMS R177679, (F) ventral view of referred specimen HNLP2016062200001, and (G) lateral view showing groin coloration of holotype VNMN 2017.002 and (H) lateral view showing groin coloration of paratype AMS R177676.
FIGURE 10 in The Vietnamese population of Megophrys kuatunensis (Amphibia: Megophryidae) represents a new species of Asian horned frog from Vietnam and southern China
FIGURE 10. Distribution of Megophrys kuatunensis after Huiqing et al. 2004. Blue polygons represent the elevational range of the species; 430–1950 m asl within the distributional range reported by the IUCN. Star denotes type locality and black circles denote the locations where M. kuatunenis have been confirmed with molecular data.
FIGURE 8. Adult male Megophrys kuatunensis holotype, AMNH 30126 in The Vietnamese population of Megophrys kuatunensis (Amphibia: Megophryidae) represents a new species of Asian horned frog from Vietnam and southern China
FIGURE 8. Adult male Megophrys kuatunensis holotype, AMNH 30126. (A) Dorsal view, and (B) ventral view. Scale bar 10.0 mm.
FIGURE 3 in The Vietnamese population of Megophrys kuatunensis (Amphibia: Megophryidae) represents a new species of Asian horned frog from Vietnam and southern China
FIGURE 3. Megophrys rubrimera sp. nov. in preservative (holotype VNMN 2017.002). (A) lateral view of head, (B) palmar surface of left hand, and (C) plantar surface of right foot. Scale bar 5.0 mm.
FIGURE 2 in The Vietnamese population of Megophrys kuatunensis (Amphibia: Megophryidae) represents a new species of Asian horned frog from Vietnam and southern China
FIGURE 2. Megophrys rubrimera sp. nov. in preservative (holotype VNMN 2017.002). (A) Dorsal view, and (B) ventral view. Scale bar 10.0 mm.
FIGURE 1 in The Vietnamese population of Megophrys kuatunensis (Amphibia: Megophryidae) represents a new species of Asian horned frog from Vietnam and southern China
FIGURE 1. Distribution of Megophrys rubrimera sp. nov. in the Hoang Lien Range, northern Vietnam and Ailao Mountain Range in Yunnan Province, China.
FIGURE 5 in The Vietnamese population of Megophrys kuatunensis (Amphibia: Megophryidae) represents a new species of Asian horned frog from Vietnam and southern China
FIGURE 5. Megophrys rubrimera sp. nov. tadpole AMS R177680. (A) Lateral view in life, (B) lateral view in preservative, (C) dorsal view in preservative, (D) ventral view of in preservative, (E) dorsal view of mouthparts in preservative, and (F) lateral view of mouthparts in preservative.
FIGURE 6 in The Vietnamese population of Megophrys kuatunensis (Amphibia: Megophryidae) represents a new species of Asian horned frog from Vietnam and southern China
FIGURE 6. Advertisement call of Megophrys rubrimera sp. nov.: 60 s waveform of relative amplitude (Rel. amp.) over time for several call groups of AMS R177677 (Ai) and unvouchered individual (b) (Bi); 20 s waveform of Rel. amp. over time for one call group of AMS R177677 (Aii) and unvouchered individual (b) (Bii); 1 s waveform and spectrogram of Rel. amp. and frequency for three and four calls of AMS R177677 (Aiii) and unvouchered individual (b) (Biii), respectively.
FIGURE 3. The holotype SYS r001242 in Description of a new species of the genus Ptychozoon (Squamata: Gekkonidae), representing a new national record of this genus from southern Yunnan Province, China
FIGURE 3. The holotype SYS r001242 of Ptychozoon bannaense sp. nov.. A: general aspect of the living holotype with broken tail; B: dorsal view of head; C: showing the infra-auricular cutaneous flap and squamation of head; D: ventral view of head; E: showing body cutaneous flap, forelimb, hand; F: showing cutaneous flaps on sides of forelimb, undivided subdigital lamellae and webbings; G: ventral view of posterior venter, hindlimbs, toes, and cutaneous flaps on sides of hindlimbs.
FIGURE 6 in Description of a new species of the genus Ptychozoon (Squamata: Gekkonidae), representing a new national record of this genus from southern Yunnan Province, China
FIGURE 6. Biotope of Ptychozoon bannaense sp. nov. in the Manheke Village, Mengyang Town, Xishuangbanna Dai Autonomous Prefecture, Yunnan Province, China.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.