Find research datasets worth reusing

opencc-by-4.0Aug 2023View details →

An Intravenous Pancreatic Cancer Therapeutic: Characterization of CRISPR/Cas9n-modified Clostridium novyi-Non Toxic Supplementary Information Histology Slides Part 4

H&E and Gram stained whole slide scans for blinded cohorts from publication titled ‘An Intravenous Pancreatic Cancer Therapeutic: Characterization of CRISPR/Cas9n-modified Clostridium novyi-Non Toxic’ published in PLOS One 2023. Excerpt from methods section of publication detailing acquisition of this data: "Formalin-fixed tissue samples were processed for paraffin embedding by the means of dehydration, clearing and paraffin infiltration (Lynx II Tissue Processor). The paraffin embedded tissue samples were sectioned using a Leica Rotatory Microtome RM2125 RTS at 5um thickness. Designated tissue sections were subsequently de-paraffined and stained with H&E and gram staining as per standard histology protocols (Leica Autostainer XL). Whole slide scanning (WSI) was performed by a Panoramic 250 whole slide scanner at 20x magnification (3D Histech) using a Carl-Zeiss Plan-Apochromat 20x / NA 0.8 objective." Please note when downloading the image files that the folder containing all of the .data files cannot contain the corresponding .mxrs file. The .mxrs and the folder containing the .data files must have identical names and be at the same file level (as uploaded). Files of this type can be opened by the open source software FIJI or QuPath, among others. Cohorts have been uploaded with viewers blinded to treatment groups to allow for unbiased review should it be desired, with a cohort key uploaded separately (doi: ##). Files are grouped so that all major organs from a single mouse are in the same compressed folder.

opencc-by-4.0Oct 2023View details →

Raw ptychography data for manuscript with title 'Structured Illumination Ptychography and At-wavelength Characterization with an EUV diffuser at 13.5 nm Wavelength'

- Given are the HDF files containing the raw diffraction patterns - Although some meta-data might be available in these files, these might not be correct. The following data were used for reconstruction:     wavelength: 13.5 nm     distance sample <-> detector: ~29.2 mm     sCMOS pixel size: 11 um     Number of incoherent modes: 4     Initial probe guess: 9 um     For the reconstruction, OPR was used (Although it might have not been necessary for all data. However, to have comparable results it was used for each reconstruction) - For each scenario, there are two data sets to calculate the Fourier ring correlation (FRC) - For the analysis of the diffuser the reconstructed probe of the data set "dp_diffuser_max_dynam_range.hdf5" was used - Data were measured at the Institute of Applied Physics in Jena using a Fiber Laser driven High-order harmonic source Please contact me (wilhelm.eschen@uni-jena.de) for additional support.

dryad40/100

Characterization of the anti-spike IgG immune response to COVID-19 vaccines in people with a wide variety of immunodeficiencies

Research on COVID-19 vaccination in immune-deficient/disordered people (IDP) has primarily focused on cancer and organ transplantation populations. In a prospective cohort of 195 IDP and 35 healthy volunteers, anti-spike IgG was detected in 88% of IDP post-dose 2, increasing to 93% by six months post-dose 3. Despite high seroconversion, median IgG levels for IDP never surpassed 1/3 that of healthy volunteers. IgG binding to Omicron BA.1 was lower than all other variants. Angiotensin-converting enzyme 2 pseudo-neutralization (% inhibition) was only modestly correlated with anti-spike IgG concentration. IgG levels were not significantly altered by participants' use of different mRNA-based vaccines, immunomodulating treatments, and prior SARS-CoV-2 infections. While our data show that three doses of COVID-19 vaccinations induce anti-spike IgG in most IDP, additional doses are needed to achieve the levels of protection in healthy volunteers. Due to the strikingly reduced IgG response to Omicron BA.1, the efficacy of additional vaccinations, including bivalent vaccines, should be studied in this population.

opencc-zeroMar 2023View details →

dryad40/100

More than mesolectic: Characterizing the nutritional niche of Osmia cornifrons

Characterizing the nutritional needs of wild bee species is an essential step to better understanding bee biology and providing suitable supplemental forage for at-risk species. Here, we aim to characterize the nutritional needs of a model solitary bee species, Osmia cornifrons (Radoszkowski), by using dietary protein-to-lipid ratio (P:L ratio) as a proxy for nutritional niche and niche breadth. We first identified the mean target P:L ratio (~3.02:1) and P:L collection range (0.75 to 6.26:1) from pollen provisions collected across a variety of sites and time points. We then investigated the P:L tolerance range of larvae by rearing bees in vitro on a variety of diets. Multifloral and single-source pollen diets with P:L ratios within the range of surveyed provisions did not always support larval development, indicating that other dietary components such as plant secondary compounds and micronutrients must also be considered in bee nutritional experiments. Finally, we used pollen metabarcoding to identify pollen from whole larval provisions to understand how much pollen bees used from plants outside of their host plant families to meet their nutritional needs, as well as pollen from individual forager bouts, to observe if bees maintained strict floral constancy or visited multiple plant genera per foraging bout. Whole larval provision surveys revealed a surprising range of host plant pollen use, ranging from ~5–70% of host plant pollen per provision. Samples from individual foraging trips contained pollen from multiple genera, suggesting that bees are using some form of foraging decision-making. Overall, these results suggest that O. cornifrons have a wide nutritional niche breadth, but while pollen P:L ratio tolerance is broad, a tolerable P:L ratio alone is not enough to create a quality diet for O. cornifrons, and the plant species that make up these diets must also be carefully considered.

opencc-zeroOct 2023View details →

opencc-by-4.0Oct 2023View details →

Structural Characterization of amphiphilic co-networks in selective and non-selective solvents using 1H-NMR and SAXS

We investigate structural properties of model amphiphilic co-networks made by heterocomplementary end-linking of tetra-PEG tetra-PCL star polymers in selective and non-selective solvent using small-angle X-ray scattering, NMR diffusometry and double-quantum magic-angle spinning (DQ MAS) NMR techniques. Here, the data used is made accessible

opencc-by-4.0Oct 2018View details →

Figure 1 in S7 characterization of Western European pikes Esox spp. (Actinopterygii, Esociformes

Figure 1. – Bayesian tree of the 1635 bp of the first intron of the S7 ribosomal protein coding gene (S7) for the 48 sequences separated by alleles of Esox spp. Numbers on the nodes represent posterior probabilities. Diagnostic indels and their location in the alignment are marked by a black triangle and position in the sequence above. Vouchers identifications are symbolized by black and white squares repre- senting respectively E. aquitanicus and E. lucius (see Denys et al., 2014), and gray dots designate E. cisalpinus. $: indicates the holotype of Esox aquitanicus Denys et al., 2014 (MNHN 2013-1246).

FGF401 in HCC and Solid Tumors Characterized by Positive FGFR4 and KLB Expression

ClinicalTrials.gov study NCT02325739. IPD Sharing: YES. Countries: 11. Publications: 2.

Ponatinib in Participants With Resistant Chronic Phase Chronic Myeloid Leukemia (CP-CML) to Characterize the Efficacy and Safety of a Range of Doses

ClinicalTrials.gov study NCT02467270. IPD Sharing: YES. Countries: 21. Publications: 2.

An Open-Label Study to Characterize the Incidence and Severity of Diarrhea in Patients With Early-Stage HER2+ Breast Cancer Treated With Neratinib and Loperamide

ClinicalTrials.gov study NCT02400476. IPD Sharing: YES. Countries: 7. Publications: 2.

Characterizing the Neural Substrates of Irritability in Women: an Experimental Neuroendocrine Model

ClinicalTrials.gov study NCT04051320. IPD Sharing: YES. Countries: 1. Publications: 98.