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Data from: Opportunities for understanding MS mechanisms and progression with MRI using large‐scale data‐sharing and artificial intelligence
<p>This is supplementary material accompanying the paper "Opportunities for understanding MS mechanisms and progression with MRI using large‐scale data‐sharing and artificial intelligence"</p>
Figure 2 from: Kapustin DA, Glushchenko AM, Kulikovskiy MS (2022) Achnanthidium bratanense sp. nov. (Bacillariophyceae, Achnanthidiaceae), a new diatom from the Lake Bratan (Bali, Indonesia). PhytoKeys 188: 167-175. https://doi.org/10.3897/phytokeys.188.77882
Figure 2 A–GAchnanthidium bratanense sp. nov. (SEM). A, B raphe valve, external view C, D rapheless valve, external view E, F raphe valve, internal view G rapheless valve, internal view. Scale bar: 1 μm.
Figure 1 from: Kapustin DA, Glushchenko AM, Kulikovskiy MS (2022) Achnanthidium bratanense sp. nov. (Bacillariophyceae, Achnanthidiaceae), a new diatom from the Lake Bratan (Bali, Indonesia). PhytoKeys 188: 167-175. https://doi.org/10.3897/phytokeys.188.77882
Figure 1 A–TAchnanthidium bratanense sp. nov. (LM). A–S size diminution series showing variation in valve outline A holotype specimen A-D, F-I, K, M, N, R raphe valves E, J, L, O-Q, S rapheless valves T frustule in girdle view. Scale bar: 10 μm.
Repurposing Domperidone in Secondary Progressive MS - A Simon 2-Stage Phase 2 Futility Trial - Table e1: Results of the binary logistic regression model
<p><b>Objective:</b> To assess whether treatment with the generic drug domperidone can reduce the progression of disability in secondary progressive multiple sclerosis (SPMS), we conducted a phase 2 futility trial following the Simon two-stage design.</p> <p><b>Methods:</b> We enrolled patients in an open-label, Simon two-stage, single-center, phase 2, single-arm futility trial at the Calgary MS Clinic if they met the following criteria: age 18 to 60 years, SPMS, screening EDSS score of 4.0 to 6.5 and screening T25FW of 9 seconds or more. Patients received domperidone 10mg QID for one year. The primary outcome was worsening of disability, defined as worsening of the T25FW performance by 20% or more at 12 months compared to at baseline. This trial is registered with ClinicalTrials.gov, number NCT02308137.</p> <p><b>Results:</b> Between February 13<sup>th</sup>, 2015 and January 3<sup>rd</sup>, 2020, 110 patients were screened, 81 received treatment, 64 completed follow-up, of whom 62 were analysed. The study did not meet its primary endpoint: 22 of 62 (35%) patients experienced significant worsening of disability, which is close to the expected proportion of 40%, and above the pre-defined futility threshold. Patients with higher prolactin levels during the study had a significantly lower risk of disability progression, which may warrant further investigation. Domperidone treatment was reasonably well tolerated, but adverse events occurred in 84% and serious adverse events in 15% of patients.</p> <p><b>Conclusions:</b> Domperidone treatment could not reject futility in reducing disability progression in SPMS. The Simon two-stage trial model may be a useful model for phase 2 studies in progressive MS.</p> <p><b>Classification of Evidence:</b> This study provides Class III evidence that in individuals with secondary progressive multiple sclerosis participating in a futility trial, domperidone treatment could not reject futility in reducing disability progression at 12 months.</p>
Figure 2 from: Kulikovskiy MS, Chudaev DA, Glushchenko AM, Kuznetsova IV, Kociolek JP (2022) Two new species of Navicula (Bacillariophyta) from Southeast Asia. PhytoKeys 190: 69-85. https://doi.org/10.3897/phytokeys.190.78164
Figure 2 A–FNavicula winoniformis Chudaev, Glushchenko, Kulikovskiy & Kociolek, sp. nov. SEM. Sample no 03572. A–C external views D–F internal views A, D the whole valve B, E central area C, F valve end. A black arrows show the terminal raphe fissures. White arrow shows the indistinct kink of raphe branch B white arrows show central raphe pores. Black arrow shows the very slightly elevated raphe-sternum C black arrow shows the terminal raphe fissure. White arrow shows the longitudinal grooves where areola openings are located. White arrowheads show the small isolated apical areolae D white arrows show the accessory rib E black arrow shows the rectangular areola opening. Black arrowhead shows the circular areola opening. White arrows show the central raphe endings. White arrowhead shows the raphe slit F black arrows show the stria which are slightly wider than virgae. White arrow shows the helicroglossa. White arrowheads show the small isolated apical areolae. Scale bars: 5 μm (A); 2 μm (B–E); 1 μm (F).
Figure 1 from: Kulikovskiy MS, Chudaev DA, Glushchenko AM, Kuznetsova IV, Kociolek JP (2022) Two new species of Navicula (Bacillariophyta) from Southeast Asia. PhytoKeys 190: 69-85. https://doi.org/10.3897/phytokeys.190.78164
Figure 1 A–PNavicula winoniformis Chudaev, Glushchenko, Kulikovskiy & Kociolek, sp. nov. LM, DIC. Size diminution series. Vietnam, slides no 00269 (A), 00318 (L, P, N), 00323 (I), 00326 (C), 00328 (B), 02079 (O), 03572 (E, F, H, K, M), 03773 (D), 04853 (J). Laos, slide no 00956 (G). Holotype (E). Scale bar: 10 μm.
Figure 4 from: Kulikovskiy MS, Chudaev DA, Glushchenko AM, Kuznetsova IV, Kociolek JP (2022) Two new species of Navicula (Bacillariophyta) from Southeast Asia. PhytoKeys 190: 69-85. https://doi.org/10.3897/phytokeys.190.78164
Figure 4 A–FNavicula sparsilineolata Chudaev, Glushchenko, Kulikovskiy & Kociolek, sp. nov. SEM. Sample no 00962. A–C external views D–F internal views A–C external views D–F internal views A, D the whole valve B, E central area C, F valve end A black arrow shows the very slightly elevated raphe-sternum B white arrows show the drop-like central pores. Black arrows show the larger triangular insertion in distal part. White arrowheads show the small projections in proximal part. Black arrowhead shows the transapical sutures C black arrow shows the terminal raphe fissure. White arrows show the longitudinal grooves where areola openings are located. Black arrowhead shows the transapical sutures. White arrowheads show the small isolated apical areolae D black arrowheads show the helictoglossae E black arrow shows the stria which slightly wider than virgae. White arrows show the areola openings occluded with hymenes. Black arrowheads show the central raphe endings. White arrowheads show the raphe slits F black arrow show the stria which are wider than virgae. Black arrowhead shows the helictoglossa. White arrowhead shows the raphe slit. Scale bars: 10 μm (A, D); 1 μm (B, C, E, F).
Figure 3 from: Kulikovskiy MS, Chudaev DA, Glushchenko AM, Kuznetsova IV, Kociolek JP (2022) Two new species of Navicula (Bacillariophyta) from Southeast Asia. PhytoKeys 190: 69-85. https://doi.org/10.3897/phytokeys.190.78164
Figure 3 A–NNavicula sparsilineolata Chudaev, Glushchenko, Kulikovskiy & Kociolek, sp. nov. LM, DIC. Size diminution series. Laos, slides no 00962 (A, B, F, C–E, G, I, J, L, M, N), 01621 (H, K). Holotype (D). Scale bar: 10 μm.
Data from: Perinatal depression and anxiety in women with MS: a population-based cohort study
<p><b>Objective: </b>To assess the occurrence of perinatal depression and anxiety in women before and after diagnosis of multiple sclerosis (MS).</p> <p><b>Methods: </b>114,629 pregnant women were included in the Norwegian Mother, Father and Child Cohort study 1999–2008. We assessed depression and anxiety by questionnaires during and after pregnancy. Women with MS were identified from national health registries and hospital records and grouped into 1) MS diagnosed before pregnancy (n = 140), MS diagnosed after pregnancy with 2) symptom onset before pregnancy (n = 98) and 3) symptom onset after pregnancy (n = 308). Thirty-five women were diagnosed with MS in the postpartum period. The reference group (n = 111,627) consisted of women without MS.</p> <p><b>Results: </b>Women with MS diagnosed before pregnancy had an adjusted odds ratio of 2.0 (95% confidence interval 1.2–3.1) for depression in the third trimester. Risk factors were adverse socioeconomic factors, history of psychiatric disease and physical/sexual abuse. The risk of anxiety was not increased. Women diagnosed with MS in the postpartum period had especially high risk of postpartum depression. Women with MS symptom onset within 5 years after pregnancy had increased risk of both depression and anxiety during pregnancy, whereas women with more than 5 years until symptom onset did not.</p> <p><b>Conclusion: </b>Women diagnosed with MS have increased risk of perinatal depression. Women with MS symptom onset within 5 years after pregnancy have increased risk of both depression and anxiety during pregnancy.</p>
Deep Learning-based Method for Automatic Resolution of GC-MS Data from Complex Samples
<p>气相色谱-质谱;多元曲线分辨率</p>
Supplementary material 2 from: Jones D, Fowler MS, Hocking S, Eastwood D (2022) Comparing field-based management approaches for invasive Winter Heliotrope (Petasites pyrenaicus, Asteraceae). NeoBiota 74: 171-187. https://doi.org/10.3897/neobiota.74.82673
Field trial site treatment group assignment
Supplementary material 1 from: Jones D, Fowler MS, Hocking S, Eastwood D (2022) Comparing field-based management approaches for invasive Winter Heliotrope (Petasites pyrenaicus, Asteraceae). NeoBiota 74: 171-187. https://doi.org/10.3897/neobiota.74.82673
Desk-based site geological, hydrological and historical surveys
Supplementary material 3 from: Jones D, Fowler MS, Hocking S, Eastwood D (2022) Comparing field-based management approaches for invasive Winter Heliotrope (Petasites pyrenaicus, Asteraceae). NeoBiota 74: 171-187. https://doi.org/10.3897/neobiota.74.82673
Petasites pyrenaicus field trial herbicide properties, manufacturers and suppliers
Shallow slip deficit and deep penetration of the 1920 Haiyuan Ms 8.5 earthquake, China
<p>The generated stochastic slip ruptures.</p>
Affinity CE-MS
<p>Affinity CE-MS of FcgRIIA</p>
MALDI-TOF MS spectra and sequence data of collagen of modern and archaeological flatfish from European waters
<p>MALDI-TOF MS spectra, LC-MS/MS datafiles, and Mascot MZID files of modern bone collagen of 18 species of Pleuronectiformes as reference spectra that were used to develop peptide biomarkers for ZooMS (Zooarchaeology by Mass Spectrometry). Details on the samples used can be found in the file "Reference spectra information.csv". Further information on the method and results can be found in the manuscript. The file names contain the type of data file and the species name. </p> <p>MALDI-TOF MS of 202 archaeological samples for Zooarchaeology by Mass Spectrometry (ZooMS) from three case study sites from around the North Sea: Barreau Saint-George ferroviaire in northern France, and 16-22 Coppergate and Blue Bridge Lane from York in the United Kingdom. Details on the samples can be found in the supplementary information of the manuscript. Further information on the method can be found in the manuscript. The file names are labeled with the sample ID number and the triplicate number (out of 3).</p>
Figures 2-9 from: Silva GL, Metzelthin MH, Da-Costa T, Rocha MS, Silva DE, Ferla NJ, Silva OS (2017) Responses of water mite assemblages (Acari) to environmental parameters at irrigated rice cultivation fields and native lakes. Zoologia 34: 1-8. https://doi.org/10.3897/zoologia.34.e19988
Figures 2-9 View of the study sites: (2) Detailed view of the rice-water samples, (3) Rice area 1 – R1, (4) Rice area 2 – R2, (5) Rice area 3 – R3, (6) Rice area 4 – R4, (7) Lake 1 – L1, (8) Lake 2 – L2, (9) Lake 3 – L3.
Figures 12-13 from: Silva GL, Metzelthin MH, Da-Costa T, Rocha MS, Silva DE, Ferla NJ, Silva OS (2017) Responses of water mite assemblages (Acari) to environmental parameters at irrigated rice cultivation fields and native lakes. Zoologia 34: 1-8. https://doi.org/10.3897/zoologia.34.e19988
Figures 12-13 Ordination diagram (first two axes) of Non-Metric Multidimensional Scaling (NMDS) using (12) Bray-Curtis and (13) Jaccard indexes with Envfit function for the evaluated environments. (▲ Lake 1, ■ Lake 2 and 3, ● Rice Area). Stress: 0.15.
Figures 10-11 from: Silva GL, Metzelthin MH, Da-Costa T, Rocha MS, Silva DE, Ferla NJ, Silva OS (2017) Responses of water mite assemblages (Acari) to environmental parameters at irrigated rice cultivation fields and native lakes. Zoologia 34: 1-8. https://doi.org/10.3897/zoologia.34.e19988
Figures 10-11 Abundance and richness of mites in rice areas cultivation and native lakes: (10) abundance adults (± SD) (Log10 X+1); (11) richness (± SD) (Log10 X+1). Different letters indicate significant differences, Tukey test, p < 0.05.
Figure 3 from: Wood KR, Appelhans MS, Wagner WL (2017) Melicope stonei, section Pelea (Rutaceae), a new species from Kaua'i, Hawaiian Islands: with notes on its distribution, ecology, conservation status, and phylogenetic placement. PhytoKeys 83: 119-132. https://doi.org/10.3897/phytokeys.83.13442
Figure 3 - Map of Kaua'i, Hawaiian Islands, with polygon indicating distribution of Melicope stonei in the Kōke'e forests.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.