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943
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ShareScore release 0.9.0
Dataset results
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Redox-sensitive bZIP68 plays a role in balancing stress tolerance with growth in Arabidopsis
GEO Series GSE133900. Arabidopsis thaliana. 24 samples. Type: Expression profiling by high throughput sequencing.
Fam46a is a regulator for gene expression in secretory tissues and plays an important role in development and homeostasis
GEO Series GSE108692. Xenopus laevis; Homo sapiens. 22 samples. Type: Expression profiling by array.
Structural distortion of β-cyclodextrin plays a key role for the pH-dependent host-guest chemistry with doxorubicin, evident by electrochemical and molecular dynamics approach
<p>β-cyclodextrin (β-CD) is the potential drug carrier to deliver antitumor drugs like doxorubicin<br> (DOX). However, the mechanism for the inclusion complex formation is still unclear and<br> needs to be explored. This study investigated the effect of pH on the inclusion of DOX into<br> thiolated β-CD (β-CD-SH) by electrochemical and molecular dynamics (MD) simulation.<br> The electrochemical study shows a clear difference at different pH. The redox peak due to the<br> DOX is strongly influenced by pH. At neutral pH, the peak intensity decreases with time,<br> while slight variation is observed at acidic and basic pH. Depicting the association of DOX to<br> the β-CD-SH cavity at neutral pH. Also, due to the association, the charge transfer resistance<br> variation increased with time at neutral pH, decreased at basic and acidic pH. The<br> electrochemical study was further supported by MD simulation, suggesting that the<br> cyclodextrins ring gets slightly elongated due to the flipping of glucose units,<br> specifically at neutral pH leads to a strong association. Also, another significant result<br> observed that the DOX forms an inclusion complex with β-CD-SH in quinol conformation,<br> not in quinone. Briefly, the study provides the necessary molecular binding information for<br> designing an effective β-CD based targeted drug delivery system.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.