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10,735
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Dataset results
10,735 results for “dependability”
Epigenome editing of microsatellite repeat enhancers reveals specific regulatory functions and tumor dependencies [NRO-Seq]
GEO Series GSE106915. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Multipartite super-enhancers function in an orientation-dependent manner [ChIP-Seq]
GEO Series GSE211236. Mus musculus. 14 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Distinct classes of genes behave as either drivers or dependents of replication timing switches (Replication-Timing).
GEO Series GSE63428. Homo sapiens. 60 samples. Type: Other.
Differential gene expression profiles between two novel murine prostate cancer cell lines derived from androgen‑dependent (PLum‑AD cells) and androgen‑independent (PLum‑AI cells) prostate cancer
GEO Series GSE151187. Mus musculus. 6 samples. Type: Expression profiling by array.
Replication-coupled nucleosome assembly and positioning by ATP-dependent chromatin remodeling enzymes
GEO Series GSE63583. Saccharomyces cerevisiae. 13 samples. Type: Other.
High activity of a broad panel of housekeeping and tissue-specific cis-regulatory elements depends on a subset of ETS proteins
GEO Series GSE88698. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other.
RNA expression across 6 strains of mice in relation to prepulse inhibition testing, as described in: Pdxdc1 (pyridoxal-dependent decarboxylase domain containing 1) modulates pre-pulse inhibition of ac
GEO Series GSE97198. Mus musculus. 54 samples. Type: Expression profiling by array.
Condition-based prediction of time-dependent reliability in composites
This paper presents a reliability-based prediction methodology to obtain the remaining useful life of composite materials subjected to fatigue degradation. Degradation phenomena such as stiffness reduction and increase in matrix micro cracks density are sequentially estimated through a Bayesian filtering framework that incorporates information from both multi-scale damage models and damage measurements, that are sequentially collected along the process. A set of damage states are further propagated forward in time by simulating the damage progression using the models in the absence of new damage measurements to estimate the time-dependent reliability of the composite material. As a key contribution, the estimation of the remaining useful life is obtained as a probability from the prediction of the time-dependent reliability, whose validity is formally proven using the axioms of Probability Logic. A case study is presented using multi-scale fatigue damage data from a cross-ply carbon-epoxy laminate.
Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats (Tibia - pQCT)
Reduced skeletal loading leads to marked bone loss. Animal models of hindlimb suspension are widely used to assess alterations in skeleton during the course of complete unloading. More recently, the effects of partial unloading on the musculoskeletal system have been interrogated in mice and rats, revealing dose-dependent effects of partial weight bearing (PWB) on the skeleton and skeletal muscle. Here, we extended these studies to determine the structural and functional skeletal alterations in 14-week-old male Wister rats exposed to 20%, 40%, 70%, or 100% of body weight for 1, 2, or 4 weeks (n equals 11–12/group). Using in vivo pQCT, we found that trabecular bone density at the proximal tibia declined in proportion to the degree of unloading and continued progressively with time, without evidence of a plateau by 4 weeks. Ex vivo measurements of trabecular microarchitecture in the distal femur by microcomputed tomography revealed deficits in bone volume fraction, 2 and 4 weeks after unloading. Histologic analyses of trabecular bone in the distal femur revealed the decreased osteoblast number and mineralizing surface in unloaded rats. Three-point bending of the femoral diaphysis indicated modest or no reductions in femoral stiffness and estimated modulus due to PWB. Our results suggest that this rat model of PWB leads to trabecular bone deterioration that is progressive and generally proportional to the degree of PWB, with minimal effects on cortical bone. This study derives results from the pQCT assay using tibia tissue.
Simulated Galactic Cosmic Ray Exposure Activates Dose-Dependent DNA Repair Response and Downregulates Glucosinolate Pathway in Arabidopsis Seedlings
This study's objective was to develop an understanding of the biological effects of space radiation on plants with the goal of producing fresh food during long duration space missions to support astronauts' nutritional and psychological needs.10-day-old Arabidopsis seedlings were exposed to simulated Galactic Cosmic Rays (GCR) and assessed for transcriptomic changes. The simulated GCR irradiation was carried out in the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Lab (BNL). The exposures were conducted acutely for two dose points at 40 cGy or 80 cGy, with sequential delivery of proton, helium, oxygen, silicon, and iron ions. Control and irradiated seedlings were then harvested and stabilized in RNAlater at 3 hrs. post irradiation. Total RNA was isolated for transcriptomic analyses using RNAseq. The data revealed that the transcriptomic responses were dose-dependent, with significant upregulation of DNA repair pathways and downregulation of glucosinolate biosynthetic pathways. Glucosinolates are important for plant pathogen defense and for the taste of a plant, which are both relevant to growing plants for spaceflight. These findings fill in knowledge gaps of how plants respond to radiation in beyond-Earth environments.
Dose-dependent skeletal deficits due to varied reductions in mechanical loading in rats (Femur - microCT, three-point bending, histomorphometry)
Reduced skeletal loading leads to marked bone loss. Animal models of hindlimb suspension are widely used to assess alterations in skeleton during the course of complete unloading. More recently, the effects of partial unloading on the musculoskeletal system have been interrogated in mice and rats, revealing dose-dependent effects of partial weight bearing (PWB) on the skeleton and skeletal muscle. Here, we extended these studies to determine the structural and functional skeletal alterations in 14-week-old male Wister rats exposed to 20%, 40%, 70%, or 100% of body weight for 1, 2, or 4 weeks (n equals 11–12/group). Using in vivo pQCT, we found that trabecular bone density at the proximal tibia declined in proportion to the degree of unloading and continued progressively with time, without evidence of a plateau by 4 weeks. Ex vivo measurements of trabecular microarchitecture in the distal femur by microcomputed tomography revealed deficits in bone volume fraction, 2 and 4 weeks after unloading. Histologic analyses of trabecular bone in the distal femur revealed the decreased osteoblast number and mineralizing surface in unloaded rats. Three-point bending of the femoral diaphysis indicated modest or no reductions in femoral stiffness and estimated modulus due to PWB. Our results suggest that this rat model of PWB leads to trabecular bone deterioration that is progressive and generally proportional to the degree of PWB, with minimal effects on cortical bone. This study derives results from the Mechanical Testing, Bone Microstructure (microCT), and bone histomorphometry assays using femur tissue.
Bayesian Separation of Non-Stationary Mixtures of Dependent Gaus
In this work, we propose a novel approach to perform Dependent Component Analysis (DCA). DCA can be thought as the separation of latent, dependent sources from their observed mixtures which is a more realistic model than Independent Component Analysis (ICA) where the sources are assumed to be independent. In general, the sources can be spatio-temporally dependent and the mixing system may be non-stationary. Here, we propose a DCA algorithm, that combines concepts of particle filters and Markov Chain Monte Carlo (MCMC) methods in order to separate non-stationary mixtures of spatially dependent Gaussian sources.
Detecting Tumor Specific Antigen-Reactive T cells from Tumor Infiltrating Lymphocytes via Interaction Dependent Fucosyl-biotinylation [RNA-seq]
GEO Series GSE145596. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
Evaluation of Tmem184b dependent gene expression changes during sensory neuron differentiation in vitro
GEO Series GSE154435. Mus musculus. 23 samples. Type: Expression profiling by high throughput sequencing.
Pharmacologic inhibition of BAF chromatin remodeling complexes as a therapeutic approach to transcription factor-dependent cancers [WES]
GEO Series GSE241449. Homo sapiens. 10 samples. Type: Other.
CD7 promotes extramedullary involvement of the B-cell acute lymphoblastic leukemia line Tanoue by enhancing integrin beta2-dependent cell adhesiveness
GEO Series GSE53651. Homo sapiens. 2 samples. Type: Expression profiling by array.
Pseudouridine-dependent ribosome biogenesis selectively regulates translation of polyglutamine proteins during Drosophila oogenesis
GEO Series GSE206692. Drosophila melanogaster. 16 samples. Type: Other.
ALKBH1-mediated DNA N6-methyladenine Modification Regulates H3K9me3-dependent Heterochromatin in Neural Tube Development [Cut & Tag]
GEO Series GSE268545. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epithelial cholangiocarcinoma cells can contribute to desmoplasia by extracellular matrix deposition and mesenchymal transition depending on the microenvironment
GEO Series GSE188527. Homo sapiens. 18 samples. Type: Expression profiling by high throughput sequencing.
Combinatorial Ixazomib and Belinostat Therapy Induce Nuclear Factor Erythroid 2-Related Factor 2 (NRF2)-Dependent Apoptosis in Hodgkin and T-cell Lymphoma
GEO Series GSE126768. Homo sapiens. 24 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.