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984
datasets available to search
ShareScore release 0.9.0
Dataset results
984 results for “Cell stress”
Inflammatory stress-mediated chromatin changes underlie dysfunction in endothelial cells. [ATAC-Seq]
GEO Series GSE267931. Homo sapiens. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Oscillatory shear stress induced extracellular vesicles mediate valvular endothelial-interstitial cell crosstalk exacerbating aortic valve calcification [RNA-Seq]
GEO Series GSE306211. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Zhenqi Granules Attenuates the Inflammatory Response of Pulmonary Epithelial Cells by Inhibiting Endoplasmic Reticulum Stress in MRSA Infection
GEO Series GSE267856. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
SRSF1 knockdown alleviates the ribosomal stress-induced inhibition of cell proliferation through the MAPK signaling pathway
GEO Series GSE218461. Homo sapiens. 15 samples. Type: Expression profiling by high throughput sequencing.
Expression data of LN229 cells treated with 23 Pa compressive solid stress (CSS) or no CSS
GEO Series GSE137210. Homo sapiens. 8 samples. Type: Expression profiling by array.
HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex
<p><strong>The database includes </strong>the raw of the article “HuD regulates SOD1 expression during oxidative stress in differentiated neuroblastoma cells and sporadic ALS motor cortex”.</p> <p><strong>In detail, the database contains</strong> data obtained by the following evaluations: i) RNA electrophoretic mobility shift assay (REMSA) to detect the formation of a complex between HuD recombinant protein and SOD1 ARE sequences. ii) multiplex qRT-PCR to evaluate if oxidative stress levels, i.e H2O2 treatment, induces a shift in the alternative polyadenylation (APA) site usage in SOD1 3'UTR.</p> <p><strong>Aim of the work</strong> was to investigate the potential involvement of HuD (ELAVL4) one of the neuronal members of the ELAVL family, in SOD1 regulation during oxidative stress and in sporadic ALS patients (sALS).</p> <p>Using differentiated SH-SY5Y cells along with brain tissues from sALS patients, we evaluated HuD-dependent regulation of SOD1 mRNA. By means in vitro binding and mRNA decay assays we observed that HuD specifically binds to SOD1 ARE motifs promoting mRNA stabilization. In SH-SY5Y cells, we faound that the overexpression of full-length HuD increased SOD1 mRNA and protein levels; moreover HuD regulation of SOD1 mRNA we found that this regulation is related to oxidative stress, as shown after H2O2 exposure. H2O2 exposure also induced a shift in the APA site usage in SOD1 3'UTR, increasing the levels of a long variant bearing HuD binding sites. We validated this data using a specific siRNA. In the motor cortex from sALS patients, we found increases in SOD1 and HuD mRNAs and proteins, accompanied by greater HuD binding to this mRNA as confirmed by RNA-immunoprecipitation (RIP) assays.</p> <p><strong>To conclude,</strong> these results point a role of HuD in the post-transcriptional regulation of SOD1 expression in neurons after oxidative stress and in sALS brain tissues, thus suggesting an involvement in ALS pathogenesis.</p>
Dataset relate to the article "Oxidative Stress and Arginine/Nitric Oxide Pathway in Red Blood Cells Derived from Patients with Prediabetes"
<p>This record contains row data relaed to the article "Oxidative Stress and Arginine/Nitric Oxide Pathway in Red Blood Cells Derived from Patients with Prediabetes"</p> <p><strong>Abstract: </strong>The effects of the oral glucose tolerance test (OGTT) on red blood cells (RBCs) have not been thoroughly investigated, although it is known that the<strong> </strong>ingestion of<strong> </strong>75-g<strong> </strong>glucose during OGTT results in a systemic state of inflammation and oxidative stress. Therefore, we evaluated the effect of OGTT on oxidative stress and L-Arginine/Nitric Oxide (L-Arg/NO) metabolic pathway in RBCs obtained from patients with prediabetes. Blood samples were collected from all participants before (T0) and at 10 (T1), 20 (T2), 30 (T3), 60 (T4), 90 (T5), 120 (T6), 150 (T7), and 180 (T8) minutes after glucose loading. Results showed a significant increase in oxidative stress status characterized by a rise in the GSSG/GSH ratio at T4 and T6 that went in parallel with a reduction of NO production in RBCs. In addition, in this time frame, increased exposure of phosphatidylserine on RBCs membrane was observed. These metabolic modifications were rescued at T8, together with an increase in activated RBC NO synthase expression.<strong> T</strong>hese findings provide a possible explanation of the phenomena occurring after glucose loading and suggest that, even in the early stages of diabetes, it may be important to avoid acute variations in glycemia in order to prevent diabetic complications.</p>
Metformin treatment reduces oxidative stress state of RNASEH2-mutated Aicardi-Goutières patients-derived Lymphoblastoid Cell Lines
<p>The database includes the raw data of the article “Metformin treatment reduces oxidative stress state of RNASEH2-mutated Aicardi-Goutières patients-derived Lymphoblastoid Cell Lines”. Aim of this work was was to examine the impact of metformin treatment on the oxidative stress state of lymphoblastoid cell lines (LCLs) carrying mutation in RNASEH2B and RNASEH2A AGS related genes and healthy control. The database contains the data obtained by the following evaluations: a) Flow cytometry analysis for the evaluation of ROS release; b) Immunofluorescence for the evaluation of the stress-induced DNA damage by the quantification of the 8-OxoG level and changes of altered membrane potential by the quantification of monomeric and aggregated JC-1 dye; c) RT-qPCR for the evaluation of the expression level of FOXO3-related pathway.</p> <p>We demonstrated that metformin is able to highly reduce ROS overproduction especially in RNASEH2B-mutated LCLs, to restore the impaired mitochondrial membrane potential and strongly reduce the oxidative DNA damage by reducing the 8-oxoG level in AGS patients. We demonstrated that the beneficial effect of metformin associate with the upregulation of FOXO3-related signaling pathway. Metformin treatment seem to represents a possible therapeutic approach, useful to ameliorate the oxidative stress-related inflammatory condition observed in AGS subjects.</p>
Rps15 mutation drives B cell malignancy through translational rewiring, oxidative stress and genomic instability
GEO Series GSE293841. Mus musculus. 51 samples. Type: Expression profiling by high throughput sequencing; Other.
Zfp521 is essential for the quiescence and maintenance of adult hematopoietic stem cells under stress
GEO Series GSE163684. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Spheroid growth in ovarian cancer promotes gene expression involved in epithelial-mesenchymal transition, stem cell promotion, and multiple stress responses
GEO Series GSE80373. Homo sapiens. 8 samples. Type: Expression profiling by array.
Effects of stress of the endoplasmic reticulum on gene expression in the bovine liver cell model BHF12
GEO Series GSE305850. Bos taurus. 15 samples. Type: Expression profiling by array.
Stress-related gene expression in HK-2 cells exposed to pH 7.4, 7.0 or 6.7
GEO Series GSE23995. Homo sapiens. 3 samples. Type: Expression profiling by array.
Genes related to cell wall metabolisms are targeted by miRNAs in immature tomato fruits under drought stress
GEO Series GSE218817. Solanum lycopersicum. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
An inflammatory single-cell RNA sequencing signature driven by metabolic stress in a new mouse model of heart failure with preserved ejection fraction and its reversion by the SGLT2 inhibitor dapaglif
GEO Series GSE209548. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Effect of heat stress on mouse testicular peritubular myoid cells [miRNA-seq]
GEO Series GSE125634. Mus musculus. 9 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Stress granule-mediated sequestration of EGR1 mRNAs correlates with lomustine-induced cell death prevention
GEO Series GSE269691. Homo sapiens. 24 samples. Type: Expression profiling by array.
Histone Modifications and Chromatin Accessibility in Endothelial Cells under Shear Stress (ATAC-seq)
GEO Series GSE128390. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Gene Expression in NS0 cells under ammonium stress
GEO Series GSE17495. Mus musculus. 12 samples. Type: Expression profiling by array.
3D genome architecture in MCF10A cells in repsonse to DNA damage and ER stress
GEO Series GSE275042. Homo sapiens. 6 samples. Type: Other.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.