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12,799 results for “Immunization”
Effect of dietary Chlorella vulgaris and carbohydrate-active enzymes on the general health, immune status, antioxidant capacity, and liver lipids and metabolites of weaned piglets
<p>It was evaluated the impact of dietary inclusion of <em>Chlorella vulgaris </em>(CH) and carbohydrases on the general health, immune and oxidative status, and hepatic lipids and metabolites of piglets. Forty-four male weaned piglets were allocated into four diets: control (<em>n</em>=11), CH (control diet with 5% CH, <em>n</em>=10), CH+R (control diet with 5% CH plus 0.005% Rovabio<sup>®</sup>Excel AP, <em>n</em>=10), and CH+M (control diet with 5% CH plus 0.01% of a pre-selected four-CAZyme mixture, <em>n</em>=11) for 15 days. Total cholesterol, LDL-cholesterol and VLDL-cholesterol were increased by CH. In piglets fed CH<em>-</em>based diets, the interplay observed between IgG increase and IgM decrease contributed for piglets’ survival during weaning. <em>n</em>-6 PUFA were lower in piglets fed CH with or without feed enzymes and the inverse occurred for <em>n</em>-3 PUFA, thus benefiting <em>n</em>-6/<em>n</em>-3 ratio in the liver. The discriminant analysis applied to hepatic variables revealed a good separation between control and CH-based diets but failed to discriminate feed enzymes addition. Minor variations were promoted by Rovabio or the pre-selected enzymatic mixture, thus suggesting some improvement on microalga nutrients digestibility. Taken together, our findings indicate a health promoting effect of CH as feed ingredient in piglets’ nutrition during the weaning period, without negatively impacting on animals’ performance.</p> <p> </p>
ARID1A suppresses R-loop mediated STING-Type I Interferon pathway activation of anti-tumor immunity
<p>Clinical trials have identified ARID1A mutations as enriched among patients who respond favorably to Immune Checkpoint Blockade (ICB) in several solid tumor types independent of microsatellite instability. We show that ARID1A loss in murine models is sufficient to induce anti-tumor immune phenotypes observed in ARID1A mutant human cancers, including increased CD8+ T cell infiltration and cytolytic activity. ARID1A deficient cancers upregulated an interferon (IFN) gene expression signature, the ARID1A-IFN signature, associated with increased R-loops and cytosolic single stranded DNA (ssDNA). Overexpression of the R-loop resolving enzyme, RNASEH2B, or cytosolic DNase, TREX1, in ARID1A deficient cells prevented cytosolic ssDNA accumulation and ARID1A-IFN gene upregulation. Further, the ARID1A-IFN signature and anti-tumor immunity were driven by STING dependent Type I IFN signaling, which was required for improved responsiveness of ARID1A mutant tumors to ICB treatment. These findings define a molecular mechanism underlying anti-tumor immunity in ARID1A mutant cancers.</p>
Innate immune responses against the mRNA component of mRNA vaccine promote cellular immunity through IFN-β at the injection site
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Proteomic and Metabolomic Profiling of Plasma Predict Immune-related Adverse Events in Older Patients with Advanced Non-small Cell Lung Cancer
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scTransformers - Dataset : Cross Tissue Immune Cells
<p>The annotation of cell types on single cell RNA-seq data is a complex, uncertain and time-consuming task, requiring several methods and tools to be able to annotate cells appropriately and efficiently. To overcome these problems and uncertainties, numerous tools and scientific articles have emerged over the years. The rise of artificial intelligence in our lives (notably through chatGPT), has also imposed itself on the scientific world, bringing novelty and innovation to existing techniques and tools. These tools need to be tested and studied to verify their effectiveness. In this project, two cell annotation tools in single cell RNA-seq named scBERT and scGPT are of interest to CB2M because of their ability to resolve and avoid the uncertainties and problems mentioned above. We study here, through various analyses, including cross-validation and the use of multiple qualitative and numerical indicators, that cell annotation by those tools are effective for annotating cells from scRNA-seq.</p> <p>Provided files :</p> <ul> <li>Human_Thymus_Development_Atlas_reference.tar.gz : Cell atlas of human thymic development : 15 embryonic and fetal thymuses covering stages of thymic development from 7 post-conceptional weeks (PCW) to 17 PCW, and 9 postnatal thymuses from human pediatric and adult samples. It contains 255,901 cells, 32,922 genes and 33 different cell types.</li> <li>Human_Thymus_Development_Atlas_output.tar.gz : All analysis output files</li> <li>Human_Thymus_Development_Atlas_container.tar.gz : Docker image and Singularity mages used for the analysis</li> </ul> <p>See https://github.com/CIML-bioinformatic/CB2M_scTransformers for more details.</p>
scTransformers - Dataset : Cross Tissue Immune Cells
<p>The annotation of cell types on single cell RNA-seq data is a complex, uncertain and time-consuming task, requiring several methods and tools to be able to annotate cells appropriately and efficiently. To overcome these problems and uncertainties, numerous tools and scientific articles have emerged over the years. The rise of artificial intelligence in our lives (notably through chatGPT), has also imposed itself on the scientific world, bringing novelty and innovation to existing techniques and tools. These tools need to be tested and studied to verify their effectiveness. In this project, two cell annotation tools in single cell RNA-seq named scBERT and scGPT are of interest to CB2M because of their ability to resolve and avoid the uncertainties and problems mentioned above. We study here, through various analyses, including cross-validation and the use of multiple qualitative and numerical indicators, that cell annotation by those tools are effective for annotating cells from scRNA-seq.</p> <p>Provided files:</p> <ul> <li>cross_tissue_immune_cell_reference.tar.gz : Cell atlas across tissue in human immune system : Immune compartment of 15 tissues from six deceased adult donors. It contains 329,762 cells, 36,398 genes and 35 different cell types.</li> <li>cross_tissue_immune_cell_output.tar.gz : All analysis output files</li> <li>cross_tissue_immune_cell_container.tar.gz : Docker image and Singularity mages used for the analysis</li> </ul> <p>See https://github.com/CIML-bioinformatic/CB2M_scTransformers for more details</p>
Distant metastases of breast cancer resemble primary tumors in tumor cell composition but differ in immune cell phenotypes
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Data from: Variation in immune response in the generalist herbivore fall webworm across four common host plants
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Single cell data from Imaging Mass Cytometry of mouse lung tumours treated with KRAS-G12C and immune checkpoint inhibitors (Dataset 3)
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Transcriptome profiling associated with CARD11 overexpres-sion in Colorectal Cancer implicates a potential role for Tumour Immune Microenvironment and Cancer pathways modulation via NF-κB
<p>tables for CARD11</p>
ASO-mediated knockdown of GPNMB in mutant-GRN and Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses
<p><strong>Background: </strong>Increases in GPNMB are detectable in FTD-<em>GRN</em> cerebrospinal fluid (CSF) and post-mortem brain, and brains of aged <em>Grn</em>-deficient mice. Although no upregulation of GPNMB is observed in the brains of young <em>Grn</em>-deficient mice, peripheral immune cells of these mice do exhibit this increase in GPNMB. Importantly, the functional significance of GPNMB upregulation in progranulin-deficient states is currently unknown. Given that GPNMB has been discussed as a potential therapeutic target in <em>GRN</em>-mediated neurodegeneration, it is vital for the field to determine what the normal function of GPNMB is in the immune system, and whether targeting GPNMB will elicit beneficial or deleterious effects.</p> <p><strong>Methods: </strong>The effects of GPNMB knock-down via antisense oligonucleotide (ASO) were assessed in peripheral blood mononuclear cells (PBMCs) from 25 neurologically healthy controls (NHCs) and age- and sex-matched FTD-<em>GRN </em>patients, as well as peritoneal macrophages (pMacs) from progranulin-deficient (<em>Grn</em><sup>-/-</sup>) and B6 mice. Lysosomal function, antigen presentation and MHC-II processing and recycling were assessed, as well as cytokine release and transcription.</p> <p><strong>Results: </strong>We demonstrate here that ASO-mediated knockdown of GPNMB increases lysosomal burden and cytokine secretion in FTD-GRN carrier and neurologically healthy controls (NHCs) monocytes. <span>ASO-mediated knockdown of GPNMB in <em>Grn</em>-deficient macrophages decreased lysosomal pan-cathepsin activity and protein degradation. In addition, </span>ASO-mediated knockdown of GPNMB increased MHC-II surface expression, which was driven by decreased MHC-II uptake and recycling, in macrophages from <em>Grn</em>-deficient females. Finally, ASO-mediated knockdown of GPNMB dysregulated IFN<span><span><span>g</span></span>-stimulated cytokine transcription and secretion by mouse macrophages due to the absence of regulatory actions of the GPNMB extracellular fragment (ECF). </span></p> <p><strong>Conclusions: </strong><span>Our data herein reveals that </span>GPNMB has a regulatory effect on multiple immune effector functions, including capping inflammation and immune responses in myeloid cells via secretion of its ECF. Therefore, in progranulin-deficient states, the drastic upregulation in GPNMB transcript and protein may represent a compensatory mechanism to preserve lysosomal function in myeloid cells. These novel findings indicate that targeted depletion in FTD-<em>GRN</em> would not be a rational therapeutic strategy because it is likely to dysregulate important immune cell effector functions.</p>
Supplemental Material from: Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes with Different Treatment Needs
<p>Supplemental data from: <strong>Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes with Different Treatment Needs</strong></p>
Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes with Different Treatment Needs: Supplemental Material
<p>Supplemental Material from: Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes with Different Treatment Needs</p>
Supplemental Material from: Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes with Different Treatment Needs
<p>Supplemental Data from "Immune Profiling of Thyroid Carcinomas Suggests the Existence of Two Major Phenotypes with Different Treatment Needs"</p>
Crystal structure of the LRR ectodomain from the plant immune receptor kinase SOBIR1 from Arabidopsis thaliana - native dataset
<p>This dataset includes the raw X-ray diffraction images collected on 02.02.2018 at beam line PXIII of the Swiss Light Source (SLS) Villigen, Switzerland. The dataset includes a .bz2 archive of the XDS processing, the resulting XDS_ASCII.HKL contains the integrated intensities. The corresponding coordinates and crystallographic structure factors have been deposited with the Protein Data Bank (http://rcsb.org) with ID 6R1H.</p>
Crystal structure of the LRR ectodomain from the plant immune receptor kinase SOBIR1 from Arabidopsis thaliana - sulphur SAD datasets
<p>This dataset includes the raw X-ray diffraction images collected on 06.11.2017 at beam line PXIII of the Swiss Light Source (SLS) Villigen, Switzerland. The archive native_images.tar contains a native dataset to 1.75 Å resolution (λ=1.033201 Å, 1 360° wedge at 0.1° oscillation). The archive ssad_images.tar contains redundant sulphur single-wavelength anomalous dispersion (SAD) data (λ= 2.078524 Å, 3 360° wedges at 0.1° oscillation) to 3.12 Å resolution. The xds_nat_ssad.tar.bz2 includes a .bz2 archive of the XDS processing for native and sulphur SAD data. Data were scaled together in xscale, the resulting xscale.hkl and nat1.hkl contain the integrated intensities and crystallographic structure factors. The corresponding coordinates have been deposited with the Protein Data Bank (http://rcsb.org) with ID 6R1H.</p>
Metabolic effects of a high level of dietary zinc in piglet diets to induce immune competence
<p>There is increasing consumer pressure to reduce the use of therapeutic antibiotics in animal production. Solutions to this challenge require a multi-targeted approach, including use of particular functional ingredients, such as pre- and probiotics that are not only used to boost the growth and productivity but also to influence the development of immune competence and support responsiveness of the immune system at later age. In this context there is a large interest in the development and evaluation of nutritional interventions during early life stages in farm animal species. However, apart from effects on animal growth and productivity, there is lack of knowledge in livestock on ways to modify development of immune competence by nutritional manipulation. Thus an associated project is being conducted with the objective to evaluate effects of a “model intervention” in piglets to modify development of immune competence. The associated project investigates the effects of provision of diet with a high concentration of zinc (2790 mg/kg) over different time periods in post-weaned piglets as a “model intervention” for manipulation of immune competence, compared to a reference treatment, in which the animals are fed a diet with a basal level of zinc.</p> <p>The objective of the associated project is to investigate the effects of high concentration of zinc on functional and metabolic changes, including processes related to digestive functions of the gut, its integrity and barrier function, and on immunological processes as effected by the nutritional manipulation. In the associated project we already studied the effects of high concentration of zinc on growth performance, on composition and diversity of the microbiota in the gut, on genome-wide gene expression in intestinal tissue, and on several immune markers in blood. In this proposal we apply for funds to provide us with expertise and access to facilities in order to get a global view of the metabolic changes as induced by the high concentration of zinc by analyzing a range of metabolites in blood. </p>
Figure 1 in Blood parasites in sympatric lizards: what is their impact on hosts' immune system?
Figure 1. Circulating blood cells in P. vaucheri and S. perspicillata lizards: A) uninfected mature erythrocyte (oneheaded arrow) and immature erythrocyte (double-headed arrow); B) and C) haemogregarine parasites infecting erythrocytes; D) heterophil cell (double-headed arrow) and two thrombocytes (one-headed arrows); E) an eosinophil (one-headed arrow) and a lymphocyte (double-headed arrow); F) one azurophil; G) one monocyte and H) one basophil. Scale black bar = 10 µm.
Figure 3 in Blood parasites in sympatric lizards: what is their impact on hosts' immune system?
Figure 3. Boxplot of the variation in swelling response to PHA (%) among infected individuals by species, localities and sexes. The black line inside the box represents the mean swelling, box represent 50% of the central values, and the extremes represent the minimum and maximum values (excluding outliers).
Figure 2 in Blood parasites in sympatric lizards: what is their impact on hosts' immune system?
Figure 2. Estimate of phylogenetic relationships based on a Bayesian analysis of 18S rDNA sequences of haemogregarines. Statistical support is reported for relevant nodes: above, Bayesian Posterior Probabilities> 90; below, bootstrap values for ML> 70; + indicates support of 100%. Clades presented with triangles were collapsed in height by 75%. The sequences from this study are indicated in bold with sample codes given inside parenthesis.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.