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2,897 results for “adjuvants”
Dataset: Co-administration of adjuvanted recombinant Ov-103 and Ov-RAL2 vaccines confer protection against natural challenge in a bovine O. ochengi infection model of human onchocerciasis
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Data from: Entomopathogenic Nematodes Combined with Adjuvants Presents a New Potential Biological Control Method for Managing the Wheat Stem Sawfly, Cephus cinctus (Hymenoptera: Cephidae)
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Data from: Comparison of Nottingham Prognostic Index and Adjuvant Online prognostic tools in young women with breast cancer: review of a single-institution experience
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Data from: Modified antibiotic adjuvant ratios can slow and steer the evolution of resistance: Co-amoxiclav as a case study
As antibiotic resistance spreads, developing sustainable methods to restore the efficacy of existing antibiotics is increasingly important. One widespread method is to combine antibiotics with synergistically acting adjuvants that inhibit resistance mechanisms, allowing drug killing. Here we use co-amoxiclav (a clinically important combination of the -lactam antibiotic amoxicillin and the -lactamase inhibitor clavulanate) to ask whether treatment efficacy and resistance evolution can be decoupled via component dosing modifications. A simple mathematical model predicts that different ratios of these two drug components can produce distinct evolutionary responses irrespective of initial efficacy. We test this hypothesis by selecting Escherichia coli with a plasmid encoded -lactamase (CTX-M-14), against different compositions of amoxicillin and clavulanate. Consistent with our theory, we found that while resistance evolved under all conditions, the component ratio influenced both the rate and mechanism of resistance evolution. Specifically, we found that the current clinical practice of high amoxicillin to clavulanate ratios resulted in the most rapid adaptation to antibiotics via gene dosing responses. Increased plasmid copy number allowed E. coli to increase -lactamase dosing and effectively titrate out low quantities of clavulanate, restoring amoxicillin resistance. In contrast, high clavulanate ratios were more robust - plasmid copy number did not increase, although porin or efflux resistance mechanisms were found, as in all drug ratios. Our results indicate that by changing the ratio of adjuvant to antibiotic we can slow and steer the path of resistance evolution. We therefore suggest using increased adjuvant dosing regimens to slow the rate of resistance evolution.
EFFECTIVENESS OF THE ANTIVIRAL DRUG RUTAN ON THE COURSE OF ADJUVANT-INDUCED ARTHRITIS.
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Immunogenicity and Safety of a Novel Adjuvanted HBV Vaccine in Pre-liver Transplant Patients 18 Years of Age
ClinicalTrials.gov study NCT00697554. IPD Sharing: YES. Countries: 0. Publications: 2.
Neoadjuvant or Adjuvant Chemotherapy in Patients With Operable Non-small-cell Lung Cancer
ClinicalTrials.gov study NCT00913705. IPD Sharing: Not stated. Countries: 0. Publications: 1.
UAB 0718 - Phase II Trial to Assess Target Oral Therapy as Adjuvant Chemoprevention in High-Risk Head and Neck Cancer
ClinicalTrials.gov study NCT00570232. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Connected Prehabilitation Program During Neo Adjuvant Chemotherapy
ClinicalTrials.gov study NCT04451369. IPD Sharing: NO. Countries: 0. Publications: 1.
Comparison of Immediate and Delayed Adjuvant Chemotherapy in Treating Patients Who Have Undergone a Radical Cystectomy for Stage III or Stage IV Transitional Cell Carcinoma of the Bladder Urothelium
ClinicalTrials.gov study NCT00028756. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Baclofen as a Perioperative Analgesic Adjuvant
ClinicalTrials.gov study NCT03720717. IPD Sharing: YES. Countries: 1. Publications: 0.
Safety and Immunogenicity of Different Formulations of an MF59-Adjuvanted Influenza Vaccine in Older Adults
ClinicalTrials.gov study NCT04782323. IPD Sharing: YES. Countries: 4. Publications: 0.
Concurrent Adjuvant Carboplatin and Accelerated Radiotherapy for Triple Negative Breast Cancer
ClinicalTrials.gov study NCT01289353. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Immunogenicity of A/H1N1-SOIV (Swine Flu) Vaccine With and Without Adjuvant in Children (3 to < 9 Years)
ClinicalTrials.gov study NCT00972816. IPD Sharing: Not stated. Countries: 2. Publications: 0.
BrUOG 295: Adjuvant FOLFOX-A For Resected Pancreatic Cancer: A Phase II Brown University Oncology Research Group Trial
ClinicalTrials.gov study NCT02022033. IPD Sharing: NO. Countries: 1. Publications: 0.
Lenalidomide as Immune Adjuvant in Patient's With Chronic Lymphocytic Leukemia (CLL)
ClinicalTrials.gov study NCT01924169. IPD Sharing: Not stated. Countries: 1. Publications: 0.
The Effect of Oral Nanocurcumin as an Adjuvant Therapy for Anogenital Warts: Evaluation of Clinical Improvement, NFĸB, IFN-γ, and FOXP3+TReg From Lesions Tissue
ClinicalTrials.gov study NCT06281353. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety, Efficacy, Immunogenicity Study of GSK Biologicals' HBV Viral Vector and Adjuvanted Proteins Vaccine (GSK3528869A) in Adult Patients With Chronic Hepatitis B Infection
ClinicalTrials.gov study NCT03866187. IPD Sharing: YES. Countries: 9. Publications: 0.
Eribulin in Combination With Capecitabine for Adjuvant Treatment in Estrogen Receptor-Positive Early Stage Breast Cancer
ClinicalTrials.gov study NCT01439282. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Randomized, Double-Blind Phase II Study of Adjuvant Pembrolizumab Versus Placebo in Head and Neck Cancers at High Risk for Recurrence- the PATHWay Study
ClinicalTrials.gov study NCT02841748. IPD Sharing: Not stated. Countries: 1. Publications: 0.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.