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83 results for “992”
Figure 8 from: Li D, Hao J, Yao X, Liu Y, Peng T, Jin Z, Meng F (2020) Observations of the foraging behavior and activity patterns of the Korean wood mouse, Apodemus peninsulae, in China, using infra-red cameras. ZooKeys 992: 139-155. https://doi.org/10.3897/zookeys.992.57028
Figure 8 Interactions between temperature and feeding behavior of A. peninsulae.
Figure 2 from: Li D, Hao J, Yao X, Liu Y, Peng T, Jin Z, Meng F (2020) Observations of the foraging behavior and activity patterns of the Korean wood mouse, Apodemus peninsulae, in China, using infra-red cameras. ZooKeys 992: 139-155. https://doi.org/10.3897/zookeys.992.57028
Figure 2 Proportion of three types behaviors of A. peninsulae.
Data set from Bosè F, Renna LV, Fossati B, Arpa G, Labate V, Milani V, Botta A, Micaglio E, Meola G, Cardani R. TNNT2 Missplicing in Skeletal Muscle as a Cardiac Biomarker in Myotonic Dystrophy Type 1 but Not in Myotonic Dystrophy Type 2. Front Neurol. 2019 Sep 27;10:992. doi: 10.3389/fneur.2019.00992. PMID: 31611837; PMCID: PMC6776629.
<p>Data set from Bosè F, Renna LV, Fossati B, Arpa G, Labate V, Milani V, Botta A, Micaglio E, Meola G, Cardani R. TNNT2 Missplicing in Skeletal Muscle as a Cardiac Biomarker in Myotonic Dystrophy Type 1 but Not in Myotonic Dystrophy Type 2. Front Neurol. 2019 Sep 27;10:992. doi: 10.3389/fneur.2019.00992. PMID: 31611837; PMCID: PMC6776629.</p> <p> </p> <p>This is the abstract:</p> <p> </p> <p>Cardiac involvement is one of the most important manifestations of the multisystemic phenotype of patients affected by myotonic dystrophy (DM) and represents the second cause of premature death. Molecular mechanisms responsible for DM cardiac defects are still unclear; however, missplicing of the cardiac isoform of troponin T (<em>TNNT2</em>) and of the cardiac sodium channel (<em>SCN5A</em>) genes might contribute to the reduced myocardial function and conduction abnormalities seen in DM patients. Since, in DM skeletal muscle, the <em>TNNT2</em> gene shows the same aberrant splicing pattern observed in cardiac muscle, the principal aim of this work was to verify if the <em>TNNT2</em> aberrant fetal isoform expression could be secondary to myopathic changes or could reflect the DM cardiac phenotype. Analysis of alternative splicing of <em>TNNT2</em> and of several genes involved in DM pathology has been performed on muscle biopsies from patients affected by DM type 1 (DM1) or type 2 (DM2) with or without cardiac involvement. Our analysis shows that missplicing of muscle-specific genes is higher in DM1 and DM2 than in regenerating control muscles, indicating that these missplicing could be effectively important in DM skeletal muscle pathology. When considering the <em>TNNT2</em> gene, missplicing appears to be more evident in DM1 than in DM2 muscles since, in DM2, the <em>TNNT2</em> fetal isoform appears to be less expressed than the adult isoform. This evidence does not seem to be related to less severe muscle histopathological alterations that appear to be similar in DM1 and DM2 muscles. These results seem to indicate that the more severe <em>TNNT2</em> missplicing observed in DM1 could not be related only to myopathic changes but could reflect the more severe general phenotype compared to DM2, including cardiac problems that appear to be more severe and frequent in DM1 than in DM2 patients. Moreover, <em>TNNT2</em> missplicing significantly correlates with the QRS cardiac parameter in DM1 but not in DM2 patients, indicating that this splicing event has good potential to function as a biomarker of DM1 severity and it should be considered in pharmacological clinical trials to monitor the possible effects of different therapeutic approaches on skeletal muscle tissues.</p> <p><strong>Keywords: </strong> alternative splicing; cardiac involvement; cardiac troponin T; myotonic dystrophies; skeletal muscle.</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.