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185
datasets available to search
ShareScore release 0.9.0
Dataset results
185 results for “Anthracyclines”
Pharmacogenetics and Drug Discovery for Anthracycline-Induced Cardiotoxicity Enabled by Sinoatrial Node-like Cells Derived from Human Pluripotent Stem Cells [RNA-seq]
GEO Series GSE118085. Homo sapiens. 17 samples. Type: Expression profiling by high throughput sequencing.
Identification of novel hyper- or hypo-methylated CpG sites and genes associated with anthracycline-induced cardiomyopathy
GEO Series GSE224359. Homo sapiens. 104 samples. Type: Methylation profiling by genome tiling array.
Essential role of formyl peptide receptor 1 in anthracycline-based anticancer chemotherapy
GEO Series GSE63410. Mus musculus. 11 samples. Type: Expression profiling by array.
Global gene expression analysis of anthracycline-resistant breast cancer cell lines
GEO Series GSE54326. Homo sapiens. 24 samples. Type: Expression profiling by array.
Pharmacogenetics and Drug Discovery for Anthracycline-Induced Cardiotoxicity Enabled by Sinoatrial Node-like Cells Derived from Human Pluripotent Stem Cells [scRNA-Seq]
GEO Series GSE119682. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Genome-wide analysis of gene expression modulated by anthracycline-based chemotherapy CHOEP in malignant T-cell lines
GEO Series GSE129289. Homo sapiens. 30 samples. Type: Expression profiling by array.
Epigenetic changes due to histone eviction induced by anthracycline doxorubicin and aclarubicin
GEO Series GSE33633. Homo sapiens. 3 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Genomic predictor of response and survival following neoadjuvant taxane-anthracycline chemotherapy in breast cancer
GEO Series GSE25066. Homo sapiens. 508 samples. Type: Expression profiling by array.
Epigenetically regulated expression of ALDH1 by anthracyclines causes an adaptive oxidative response and drug resistance in AML
GEO Series GSE295068. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Anthracycline resistance in four human cancer cell lines (HGU95A)
GEO Series GSE3927. Homo sapiens. 8 samples. Type: Expression profiling by array.
Haptoglobin Gene Expression and Anthracycline-related Cardiomyopathy in Childhood Cancer Survivors
GEO Series GSE218276. Homo sapiens. 104 samples. Type: Expression profiling by high throughput sequencing.
Data from: Determining the genetic basis of anthracycline-cardiotoxicity by response QTL mapping in induced cardiomyocytes
Anthracycline-induced cardiotoxicity (ACT) is a key limiting factor in setting optimal chemotherapy regimes, with almost half of patients expected to develop congestive heart failure given high doses. However, the genetic basis of sensitivity to anthracyclines remains unclear. We created a panel of iPSC-derived cardiomyocytes from 45 individuals and performed RNA-seq after 24h exposure to varying doxorubicin dosages. The transcriptomic response is substantial: the majority of genes are differentially expressed and over 6000 genes show evidence of differential splicing, the later driven by reduced splicing fidelity in the presence of doxorubicin. We show that inter-individual variation in transcriptional response is predictive of in vitro cell damage, which in turn is associated with in vivo ACT risk. We detect 447 response-expression QTLs and 42 response-splicing QTLs, which are enriched in lower ACT GWAS p-values, supporting the in vivo relevance of our map of gene tic regulation of cellular response to anthracyclines.
Exercise to Prevent AnthraCycline-based Cardio-Toxicity Study 2.0 (EXACT2)
ClinicalTrials.gov study NCT03748550. IPD Sharing: NO. Countries: 1. Publications: 0.
Early Detection of Patients at Risk of Developing Anthracycline Cardiotoxicity With TEP/CT -FDG
ClinicalTrials.gov study NCT04892667. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Gemcitabine Plus Cisplatin Single Dose Versus Split Dose in the Treatment of Patients With Locally Advanced or Metastatic Breast Cancer After Failure of Anthracyclines and/or Taxanes
ClinicalTrials.gov study NCT00192101. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Combination Chemotherapy in Treating Patients With Intermediate-Grade or High-Grade Non-Hodgkin's Lymphoma Who Have Not Responded to Anthracycline-Containing Combination Chemotherapy
ClinicalTrials.gov study NCT00002488. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Low-dose CT-based Method for Detection of Subclinical Anthracycline-induced Cardiotoxicity
ClinicalTrials.gov study NCT03553654. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of Sequencing of Anthracyclines and Taxanes for Locally Advanced HER2-negative Breast Cancer
ClinicalTrials.gov study NCT04540692. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Defining Late Onset Occult Asymptomatic Cardiotoxicity in Childhood Cancer Survivors Exposed to Anthracycline Therapy
ClinicalTrials.gov study NCT01671696. IPD Sharing: NO. Countries: 1. Publications: 0.
Study in Patients With Advanced Soft Tissue Sarcoma (STS) After Failure of Anthracyclines and/or Ifosfamide
ClinicalTrials.gov study NCT01299506. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.