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Dataset results
224 results for “Antihypertensive”
Preeclampsia Postpartum Antihypertensive Treatment
ClinicalTrials.gov study NCT04298034. IPD Sharing: NO. Countries: 1. Publications: 11.
Effect of Antihypertensive Agents Over Sleep Apnea
ClinicalTrials.gov study NCT01896661. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Stopping Antihypertensive Treatment amOng Hypertensive Patients in Primary Care (STOP-Trial)
ClinicalTrials.gov study NCT02268071. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Efficacy of Aliskiren When Added to Standardized Losartan and Optimal Antihypertensive Therapy in Patients With Hypertension, Type 2 Diabetes and Proteinuria
ClinicalTrials.gov study NCT00097955. IPD Sharing: Not stated. Countries: 12. Publications: 2.
Renin Profiling in Selection of Initial Antihypertensive Drug
ClinicalTrials.gov study NCT00834600. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Antihypertensive Efficacy and Tolerability and Determine the Adequate Antihypertensive Dosage of Fimasartan in Mild to Moderate Essential Hypertension Patients
ClinicalTrials.gov study NCT00923611. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Efficacy and Safety of Cleviprex in Ventriculostomy Patients Requiring IV Antihypertensive Therapy
ClinicalTrials.gov study NCT01042574. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Timing of Antihypertensive Medications on Key Outcomes in Hemodialysis
ClinicalTrials.gov study NCT03327909. IPD Sharing: NO. Countries: 1. Publications: 1.
Effects of Antihypertensive Treatment in HIV Infected Patients: Candesartan Versus Lercanidipine
ClinicalTrials.gov study NCT00564057. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Clevidipine for the Antihypertensive Treatment of Acute Intracerebral Hemorrhage
ClinicalTrials.gov study NCT06402968. IPD Sharing: NO. Countries: 1. Publications: 0.
Antihypertensive Effect of Different Doses of Rostafuroxin in Comparison With Losartan
ClinicalTrials.gov study NCT03217825. IPD Sharing: NO. Countries: 1. Publications: 1.
Study of Clevidipine Assessing Its Preoperative Antihypertensive Effect in Cardiac Surgery (ESCAPE-1)
ClinicalTrials.gov study NCT00093249. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Intensive Postpartum Antihypertensive Treatment
ClinicalTrials.gov study NCT05687344. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ACEI/CCB Versus ACEI/DIU Combination Antihypertensive Therapy in Chinese Hypertensive Patients (ACvAD)
ClinicalTrials.gov study NCT03682692. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Administration Time-dependent Antihypertensive Effects of Low Dose Aspirin in Well-controlled Hypertensive Patients
ClinicalTrials.gov study NCT00386529. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Study of Clevidipine Assessing Its Postoperative Antihypertensive Effect in Cardiac Surgery (ESCAPE-2)
ClinicalTrials.gov study NCT00093262. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Association of Angiotensin-II stimulating antihypertensive use and dementia risk: Post hoc analysis of the preDIVA trial
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Genetically determined blood pressure, antihypertensive drug classes and risk of stroke subtypes
<p><b>Objective: </b>We employed Mendelian Randomization to explore whether the effects of blood pressure (BP) and BP lowering through different antihypertensive drug classes on stroke risk vary by stroke etiology.</p> <p><b>Methods: </b>We selected genetic variants associated with systolic and diastolic BP and BP-lowering variants in genes encoding antihypertensive drug targets from a GWAS on 757,601 individuals. Applying two-sample Mendelian randomization, we examined associations with any stroke (67,162 cases; 454,450 controls), ischemic stroke and its subtypes (large artery, cardioembolic, small vessel stroke), intracerebral hemorrhage (ICH, deep and lobar), and the related small vessel disease phenotype of WMH.</p> <p><b>Results</b>: Genetic predisposition to higher systolic and diastolic BP was associated with higher risk of any stroke, ischemic stroke, and ICH. We found associations between genetically determined BP and all ischemic stroke subtypes with a higher risk of large artery and small vessel stroke compared to cardioembolic stroke, as well as associations with deep, but not lobar ICH. Genetic proxies for calcium channel blockers, but not beta blockers, were associated with lower risk of any stroke and ischemic stroke. Proxies for CCBs showed particularly strong associations with small vessel stroke and the related radiological phenotype of WMH.</p> <p><b>Conclusions: </b>This study supports a causal role of hypertension in all major stroke subtypes except lobar ICH. We find differences in the effects of BP and BP lowering through antihypertensive drug classes between stroke subtypes and identify calcium channel blockade as a promising strategy for preventing manifestations of cerebral small vessel disease.</p>
Figure 1 from: Pradana AT, Ritthidej GC, Limprasutr V, Wongtayan A, Lipipun V, Iksen (2024) Antihypertensive activity of spray-dried nanoemulsion containing Asiatic acid-Palm oil in high salt diet-fed rats. Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e115091
Figure 1 Antihypertensive activity study in rats: Study timeline (A), Oral administration (B), Non-invasive blood pressure instrument (C), Animal handling on indirect blood pressure test (D).
Figure 7 from: Pradana AT, Ritthidej GC, Limprasutr V, Wongtayan A, Lipipun V, Iksen (2024) Antihypertensive activity of spray-dried nanoemulsion containing Asiatic acid-Palm oil in high salt diet-fed rats. Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e115091
Figure 7 In-vivo antihypertensive activity of SD rats (n = 6-8/group); Systolic blood pressure result of 10 weeks induction and 3 weeks treatment period (A), and ACE1 activity post-treatment in serum result (B); Showed statistically different (p < 0.05) for *between non-hypertensive group with all groups, #between treatment group with matrix groups, $between matrix group with non-hypertensive groups, &between captopril and AA nanoparticles groups with AA group.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
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