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407 results for “Biological activity”
Screening of 165,988 compounds reflecting biological and chemical diversity in the Janssen Library for anti-SARS-CoV-2 activity
<p>This report describes the most relevant results of screening a diversity set of the Janssen Pharmaceutica compound collection for potential activity against SARS-CoV-2 in a stable eGFP-expressing VeroE6 cell line infected with SARS-CoV-2.</p>
Supplementary material 6 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 6 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 5 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 5 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 3 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 3 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 2 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 2 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 7 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 7 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 1 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 1 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 4 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Supplementary material 4 from: Tanaka S (2023) Biology of Patanga japonica (Orthoptera, Acrididae): Nymphal growth, host plants, reproductive activity, hatching behavior, and adult morphology. Journal of Orthoptera Research 32(1): 93-108. https://doi.org/10.3897/jor.32.95753
Fig. 19 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 19. Synthesis of prenylated flavonoids 472–494 Reagents and conditions: (a): 3,3-dimethylallyl bromide, 10% KOH; (b): MOMCl, K CO, acetone, 0 ◦ C - RT; (c): 2 3 corresponding benzaldehyde, 10% KOH ethanol/H O, RT; (d): 5% HCl, MeOH/THF, reflux; (e) NaOAc, EtOH, reflux; (f) I, pyridine, 90 ◦ C.
Fig. 18 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 18. Synthesis of prenylated flavonoids (468–471). Reagents and conditions: (a) 1.3 N NaOH, acetone; 3,3-dimethylallyl bromide, benzene, reflux; (b) 3,3-dimethylallyl bromide, 10% KOH; (c) MOMCl, K CO, acetone, 0 ◦ C to RT; (d) p-methoxymethoxyl benzaldehyde, 10% KOH (H O/EtOH); (e) NaOAc, EtOH, reflux; (f) 3N 2 3 2 HCl, MeOH, reflux; (g) I, pyridine, 90 ◦ C.
Fig. 25 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 25. Synthetic route of C-6/C-8 prenylated flavonoids from natural precusor. Reagents and conditions: (a) CH3OCH2Cl, K2CO3, acetone, RT; (b) prenyl bromide, K CO, acetone, 45 ◦ C; (c) Florisil, toluene, reflux; (d) Montmorillonite K10, toluene, reflux; (e) dilute HCl (aq.), CH OH, RT.
Fig. 17 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 17. Chemical structures of prenylated flavonoids with anti-diabetes activity (445–465) and estrogenic activity (466–467).
Fig. 15 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 15. Synthesis of icaritin derivatives (403–412). Reagents and conditions: (f) α,ω-dibromoalkanes (15 equiv), K2CO3 (5 equiv), acetone, reflux, 12 h; (g) diethylamine or dimethylamine, DMSO, RT, 4 h; (h) 1-iodopentane, Cs2CO3, acetone, reflux, 12 h, then diethylamine, DMSO, RT, 4 h.
Fig. 14 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 14. Synthesis of icaritin derivatives (393–402). Reagents and conditions: (a) ethyl iodoacetate, K2CO3, acetone, reflux, 12 h; (b) LiOH, THF, H2O, RT, 1.5 h; (c) corresponding basic amino acid, DIC, HOBt, anhydrous DMF, RT, overnight, His = histidine, Arg = arginine, Lys = lysine; (d) corresponding basic amino acid, HATU, DIPEA, anhydrous DMF, RT, overnight; (e) piperidine, DMF, RT, 20 min.
Fig. 23 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 23. Synthetic route of C-8 prenylated flavonoids. Reagents and conditions: (a) CH3OCH2Cl, K2CO3, acetone, room temp., 83–90%; (b) 4-MOMO-benzaldehyde, KOH, EtOH, reflux, 85%; (c) I2, DMSO, reflux, 8 h, 70%; (d) oxone, acetone, CH2Cl2/NaHCO3/ Na2CO3, RT; then p-toluenesulfonic acid, RT, 76%; (e) dilute HCl (aq.), EtOH, RT, 89%; (f) prenyl bromide, K2CO3, acetone, reflux, 95%; (g) microwave, PhNEt2, reflux, 82%. (h) H2SO4 (20% aq.), CH3OH, reflux, 86%; (j) DDQ, 1,4-dioxane, reflux, 76%.
Fig. 10 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 10. Synthesis of isolaxifolin (369). Reagents and conditions: (a) 3-methyl-2-butenal, Ca(OH), MeOH, 18 ◦ C, 72 h; (b) Ac O, CH Cl, 18 ◦ C, 6 h; (c) 3-methyl-2- 2 2 2 2 buten-1-ol, DEAD, PPh, THF, 0–18 ◦ C, 6 h; (d) Eu(fod), CHCl, 60 ◦ C, 6 h; (e) K CO, MeOH, 0 ◦ C, 1 h.
Fig. 24 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 24. Regioselective synthesis of C-6/C-8 prenylated flavonoids. Reagents and conditions: (a) TEA, TBDMS-Cl, H2SO4, dichloromethane, room temp., 83%; (b) Prenyl alcohol, TPP, DIAD, dichloromethane, ice bath, 56%; (c) Eu(fod), toluene, 140 ◦ C, 81%; (d) NaH, pivaloyl vanilloyl chloride (aq.), tetrahydrofuran, reflux, 3 85%; (e) CuCl, TMS-Cl, dry acetonitrile, RT, 60%; (f) i TBAF (aq.) dry tetrahydrofuran ii Pyrrolidine, H SO, 60%; (g) Pivaloyl chloride, DMAP, dry pyridine, 40 ◦ C, 2 2 4 15 min, H SO dilution; (h) TFA, dichloromethane, water, 30 ◦ C, 72%.
Fig. 7 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 7. Synthesis of icaritin derivatives (237–272). Reagents and conditions: i. bromo-carboxylic acid ethyl esters (2.5–4.0 equiv.), acetone, K2CO3, reflux, 6 h; ii. bromo-carboxylic acid ethyl esters (1.0–1.5 equiv.), acetone, K2CO3, reflux, 6 h; iii. NaOH, MeOH/H2O (2:1), rt, 4 h; iv. glutaric anhydride, DMAP, TEA, DCM, rt, 8 h.
Fig. 4 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 4. Synthesis of antiproliferative prenyl flavonoid derivatives (197–207). Reagents and conditions: (a) CH CN, ZnCl, Et O, HCl g, 0–5 ◦ C; (b) H O, reflux, 2 h; 3 2 2 2 (c) Me SO, K CO, acetone, rt, 0.5 h; (d) benzaldehyde or p-anisaldehyde, KOH, EtOH, H O, rt, 3 h; (e) CH –CHCH Br, K CO, acetone, reflux, 12 h; (f) heat, 2 4 2 3 2 2– 2 2 3 210 ◦ C, 4 h; (g) CH COONa, C H OH, reflux, 24 h; (h) I, pyridine, 90 ◦ C, 16 h; (i) KMnO, HIO, i-PrOH, H O, rt; (j) R R CHP + Ph3Br, n-BuLi, THF, rt, 24 h; (k) 1 3 2 5 2 4 4 2 2 3 equiv BBr3, ClCH2CH2Cl, rt, 2 h; (l) 8 equiv BBr3, ClCH2CH2Cl, reflux, 4 h.
Fig. 6 in A comprehensive review: Biological activity, modification and synthetic methodologies of prenylated flavonoids
Fig. 6. Synthesis of potential MDR reversal icariin derivatives (231–236). Reagents and conditions: (a) H2SO4 (2–5 equiv), 90% EtOH, reflux; 1.5 h; (b) 20% H2SO4, MeOH, reflux, 2 h; (c) 20% H SO, MeOH, 25 ◦ C, 4 h; (d) ClSO CH, Et N, 4 h, then HCl; (e) ClSO CH, pyridine, 0 ◦ C, 3 h; then HCl; (f) ClSO NH, DMA, CH Cl, 2 4 2 3 3 2 3 2 2 2 2 0 ◦ C, 3 h; (g) ClSO H, Et N, 0 ◦ C, 3 h; then HCl.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.