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806 results for “Cancer Vaccine”
Evaluation of a New Vaccine Treatment for Patients With Metastatic Skin Cancer
ClinicalTrials.gov study NCT01149343. IPD Sharing: YES. Countries: 6. Publications: 1.
Cancer Vaccine Study for Unresectable Stage III Non-small Cell Lung Cancer (START)
ClinicalTrials.gov study NCT00409188. IPD Sharing: Not stated. Countries: 33. Publications: 4.
Human Papilloma Virus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18
ClinicalTrials.gov study NCT00122681. IPD Sharing: YES. Countries: 14. Publications: 19.
Whole Cancer Cell Vaccine Protects Ovarian Functions in Tumor-bearing Mice through Downregulating CXCL10
<p><span>Young female patients with cancer are likely to become sub-fertile or infertile even if they ultimately overcome cancer through various therapies. Cancer immunotherapy has recently emerged as a promising novel therapy against cancers with high malignancy and lethality, but it is unclear whether cancer immunotherapy affects female fertility. This study employed MCA205 cell-allotransplanted B6 mice as a model to investigate whether two popular immunotherapies—PD-1 monoclonal antibody (PD-1) therapy and whole cancer cell vaccine (WCV) therapy—affect ovarian function. MCA205 allotransplanted (M) mice exhibited decreased follicle numbers at each stage, decreased proliferation, increased apoptosis, and a decreased oocyte maturation rate. WCV treatment significantly reversed these abnormalities, whereas PD-1 did not. RNA sequencing of the ovaries revealed that multiple differentially expressed genes (DEGs) were involved in inflammation pathways. Furthermore, cytokine microarray characterized CXCL10 with both biggest increment in M group and best rescue in WCV group. Next, CXCL10 antibody Immunoprecipitation in ovarian lysate and LC-MS baited the only receptor IL18R1. Furthermore, we found that CXCL10 impaired ovarian function through three pathways: inducing ovarian fibrosis through CXCL10→IL18R1→p-JNK→COL1A1, promoting primordial follicle overactivation through CXCL10→IL18R1→p-AKT, and increasing ovarian inflammation through CXCL10→IL18R1→p-P65. Finally, we rescued the decreased ovarian function in the M group by blocking the CXCL10→IL18R1 pathway with CXCL10 antibody or a CXCL10–IL18R1 interface peptide, CIBB. This study provides mechanical evidence and translational strategies for WCVs to achieve the dual functions of suppressing tumor progression while protecting ovarian function.</span></p> <p><strong><span>Supplementary dataset 1</span></strong></p> <p><span>Related to Fig. 3A and 3B. This file includes two sheets. “All_samples-fpkm” includes FPKM values of all identified genes in ovaries from CTR, M, VM, and PM group (three repeats per group); “heat map” includes all average log2 values (from three repeats per group) of 435 DEGs (</span><span>differentially expressed genes</span><span>) </span><span>at the threshold of |log2(M/CTR)| ≥ 1.</span></p> <p><strong><span>Supplementary dataset 2</span></strong></p> <p><span>Related to Fig. 3C. This file includes 33 sheets. “summary” includes all conc. values (pg/ml) of 31 plasma DECs (</span><span>differentially expressed cytokines</span><span>); “Curves” includes standard curves for all 31 cytokines; each of the other 31 sheets include the detailed assays for each plasma cytokine for CTR, M, VM, and PM group (five repeats per group).</span></p> <p><strong><span>Supplementary dataset 3</span></strong></p> <p><span>Related to Fig. 4A. This file includes two sheets. “peptides” includes all related values of all identified peptides; “Protein Groups” includes the related info. Of all proteins corresponding to the identified peptides</span></p>
Data from: Knowledge, attitudes, and practices among Indonesian urban communities regarding HPV infection, cervical cancer, and HPV vaccination
<p><strong>Background</strong>: Few studies explored Indonesian understanding of cervical cancer (CC) and the human papillomavirus (HPV) vaccination. We aimed to investigate the association between knowledge, attitudes, and practices (KAP) and socio-demographical influences <span>related to</span> HPV, CC, and vaccination among Indonesian urban citizens.</p> <p><strong>Methods</strong>: We conducted an online survey during March 2020-August 2021 using the Snowball sampling technique. The socio-demographic characteristic and KAP responses were collected via Google Forms from 400 respondents in Jakarta. The knowledge and attitudes were divided into HPV and CC (aspect 1) and HPV vaccination (aspect 2). Correlation between KAP scores was performed using Spearman's test, and multiple logistic regression analyses were conducted to determine KAP predictors.</p> <p><strong>Results</strong>: Indonesian urban citizens in Jakarta were found to have poor knowledge in individual aspects of the inquiry but moderate knowledge overall, good attitude in inquiry both in each aspect and overall, and unsatisfying practices. Overall, in the general population, men, and women respectively: 50.8%, 32.4%, and 53.6% had good knowledge; 82.0%, 75.2%, and 84.4% expressed positive attitude; and 30.3%, 15.2%, and 35.6% applied favorable practice regarding questions inquired. Knowledge was weakly correlated towards attitude (ρ=0.385) but moderately correlated with practice (ρ=0.485); attitude was moderately correlated with practice (ρ=0.577), all results: p<0.001. Significant odds ratio (OR) for predictors to good knowledge were female sex (OR=2.99), higher education (OR=2.91), and higher mother's education (OR=2.15). Factors related to positive attitudes were higher mother's education (OR=4.13), younger age (OR=1.86), and better results in the knowledge inquiries (OR=2.96). Factors that suggested better practices were female sex (OR=2.33), being employed (OR=1.68), excellent knowledge scores (OR=4.56), and positive attitudes expressions (OR=8.05). Having done one vaccination dose and intention to receive vaccines were significantly influenced by good KAP.</p> <p><strong>Conclusions</strong>: KAP had inter-association to successful CC and HPV prevention programs, and socio-demographical characteristics are critical to influencing better KAP.</p>
Vaccine Therapy and Chemotherapy With or Without Tetanus Toxoid Compared With Chemotherapy Alone in Treating Patients With Metastatic Colorectal Cancer
ClinicalTrials.gov study NCT00027833. IPD Sharing: Not stated. Countries: 2. Publications: 1.
HER-2 Pulsed DC Vaccine to Prevent Recurrence of Invasive Breast Cancer Post Neoadjuvant Chemotherapy
ClinicalTrials.gov study NCT02061423. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Lung Cancer Vaccine Plus Oral Dietary Supplement
ClinicalTrials.gov study NCT01829373. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in Patients With Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT00673777. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Vvax001 Cancer Vaccine in (Pre) Malignant Cervical Lesions
ClinicalTrials.gov study NCT03141463. IPD Sharing: Not stated. Countries: 1. Publications: 3.
S1602: Different Strains of BCG With or Without Vaccine in High Grade Non- Muscle Invasive Bladder Cancer
ClinicalTrials.gov study NCT03091660. IPD Sharing: YES. Countries: 1. Publications: 1.
A Personal Cancer Vaccine (NEO-PV-01) w/ Nivolumab for Patients With Melanoma, Lung Cancer or Bladder Cancer
ClinicalTrials.gov study NCT02897765. IPD Sharing: NO. Countries: 1. Publications: 2.
Evaluation of the Effect and Side Effect Profile of Covid-19 Vaccine in Cancer Patients
ClinicalTrials.gov study NCT04771559. IPD Sharing: NO. Countries: 1. Publications: 1.
Vaccine Therapy in Treating Lung Cancer Patients With Cancer Stem Cells
ClinicalTrials.gov study NCT02084823. IPD Sharing: Not stated. Countries: 1. Publications: 1.
PROSTVAC®-VF/TRICOM™ Vaccine for the Treatment of Metastatic Prostate Cancer After Failing Hormone Therapy
ClinicalTrials.gov study NCT00078585. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients
ClinicalTrials.gov study NCT05078866. IPD Sharing: YES. Countries: 2. Publications: 1.
Combination of PD-1 Monoclonal Antibody and HPV Vaccine in Patients With Cervical Cancer
ClinicalTrials.gov study NCT04096911. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Clinical Study of a Personalized Neoantigen Cancer Vaccine Combined With Anti-PD-1 and RFA in Patients With Solid Tumors
ClinicalTrials.gov study NCT04864379. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Oncolytic MG1-MAGEA3 With Ad-MAGEA3 Vaccine in Combination With Pembrolizumab for Non-Small Cell Lung Cancer Patients
ClinicalTrials.gov study NCT02879760. IPD Sharing: NO. Countries: 1. Publications: 2.
Multiple-Vaccine Therapy in Treating Patients With Non-small Cell Lung Cancer
ClinicalTrials.gov study NCT00633724. IPD Sharing: Not stated. Countries: 1. Publications: 6.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.