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5,412 results for “Cell differentiation”
Use of Mesenchymal Stem Cells (MSCs) Differentiated Into Neural Stem Cells (NSCs) in People With Parkinson's (PD).
ClinicalTrials.gov study NCT03684122. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Exploratory Clinical Trial of Autologous Humanized Anti-cluster of Differentiation Antigen 19/20(CD19/CD20) Dual Specific CAR-T Cells Injection
ClinicalTrials.gov study NCT04486872. IPD Sharing: NO. Countries: 1. Publications: 1.
Prospective Screening and Differentiating Common Cancers Using Peripheral Blood Cell-Free DNA Sequencing
ClinicalTrials.gov study NCT06036563. IPD Sharing: NO. Countries: 1. Publications: 5.
COPD Co-infection With Tuberculosis on Th17 Cell Differentiation
ClinicalTrials.gov study NCT04966052. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Efficacy and Safety Study of Autologous Cluster of Differentiation 34 (CD34+) Hematopoietic Progenitor Cells Transduced With Placebo or an Anti- Human Immunodeficiency Virus Type 1 (HIV-1) Ribozyme
ClinicalTrials.gov study NCT00074997. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Influence of Preconceptional Obesity on the Myometrial Cells Differentiation Toward a Contractyl Phenotype
ClinicalTrials.gov study NCT01762683. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Tai-Chi-Chuan on Differentiation and Maturation of Dendritic Cells
ClinicalTrials.gov study NCT00322959. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Differential requirements for the RAD51 paralogs in genome repair and maintenance in human cells
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Differentiation of parathyroid hormone expressing cells from human pluripotent stem cells
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Blood cell differential count discretization modeling predicts survival in adults reporting to the emergency room: a retrospective cohort study
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Endocannabinoid signalling in stem cells and cerebral organoids drives differentiation to deep layer projection neurons via CB1 receptors
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SIRT2 is required for NaBT-induced CRC cell differentiation
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Data from: Monocyte recruitment to the dermis and differentiation to dendritic cells increases the targets for Dengue virus replication
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Single-cell glycomics analysis by CyTOF-Lec reveals glycan features defining cells differentially susceptible to HIV
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Dataset and link to dataset related to article "MicroRNA-127-3p controls murine hematopoietic stem cell maintenance by limiting differentiation."
<p>The balance between self-renewal and differentiation is crucial to ensure the homeostasis of the hematopoietic system, and is a hallmark of hematopoietic stem cells. However, the underlying molecular pathways, including the role of micro-RNA, are not completely understood. To assess the contribution of micro-RNA, we performed micro-RNA profiling of hematopoietic stem cells and their immediate downstream progeny multi-potent progenitors from wild-type control and Pbx1-conditional knockout mice, whose stem cells display a profound self-renewal defect. Unsupervised hierarchical cluster analysis separated stem cells from multi-potent progenitors, suggesting that micro-RNA might regulate the first transition step in the adult hematopoietic development. Notably, Pbx1-deficient and wild-type cells clustered separately, linking micro-RNAs to self-renewal impairment. Differential expression analysis of micro-RNA in the physiological stem cell-to-multi-potent progenitor transition and in Pbx1-deficient stem cells compared to control stem cells revealed miR-127-3p as the most differentially expressed. Furthermore, miR-127-3p was strongly stem cell-specific, being quickly down-regulated upon differentiation and not re-expressed further downstream in the bone marrow hematopoietic hierarchy. Inhibition of miR-127-3p function in Lineage-negative cells, achieved through a lentiviral-sponge vector, led to severe stem cell depletion, as assessed with serial transplantation assays. miR-127-3p-sponged stem cells displayed accelerated differentiation, which was uncoupled from proliferation, accounting for the observed stem cell reduction. miR-127-3p overexpression in Lineage-negative cells did not alter stem cell pool size, but gave rise to lymphopenia, likely due to lack of miR-127-3p physiological downregulation beyond the stem cell stage. Thus, tight regulation of miR-127-3p is crucial to preserve the self-renewing stem cell pool and homeostasis of the hematopoietic system.</p> <p> </p> <p>Raw data relative to Figure 1 have been deposited in NCBI's Gene Expression Omnibus and are accessible through GEO Series accession number GSE113062, <a href="https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113062">https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE113062</a></p>
Raw data related to: "Transcriptional Regulators of T Helper 17 Cell Differentiation in Health and Autoimmune Diseases"
<p><strong>Introduction</strong></p> <p>T helper (Th) 17 cells are a subtype of CD4 T lymphocytes characterized by the expression of retinoic acid-receptor (RAR)-related orphan receptor (ROR)γt transcription factor, encoded by gene <em>Rorc</em>. These cells are implicated in the pathology of autoimmune inflammatory disorders as well as in the clearance of extracellular infections. The main function of Th17 cells is the production of cytokine called interleukin (IL)-17A.</p> <p><strong>Methods</strong></p> <p>We described the lineage defining transcription factor RORγt and other factors that regulate transcription of <em>Il17a, Rorc </em>and Th17-related genes, such as Il17f, Il21, Il23r, which may positively or negatively influence their expression.</p> <p><strong>Results</strong></p> <p>We discussed the potential new therapeutic approaches for Th17-related diseases targeting these transcription factors. The wide knowledge of transcriptional regulators of Th17 cells is crucial for the better understanding of the pathogenic role of these cells and for development of therapeutic strategies aimed at fighting Th17-related diseases.</p>
Data Repository: Single-cell mapper (scMappR): using scRNA-seq to infer cell-type specificities of differentially expressed genes
<p>Data repository for the scMappR manuscript:</p> <p>Abstract from biorXiv (https://www.biorxiv.org/content/10.1101/2020.08.24.265298v1.full).</p> <p>RNA sequencing (RNA-seq) is widely used to identify differentially expressed genes (DEGs) and reveal biological mechanisms underlying complex biological processes. RNA-seq is often performed on heterogeneous samples and the resulting DEGs do not necessarily indicate the cell types where the differential expression occurred. While single-cell RNA-seq (scRNA-seq) methods solve this problem, technical and cost constraints currently limit its widespread use. Here we present single cell Mapper (scMappR), a method that assigns cell-type specificity scores to DEGs obtained from bulk RNA-seq by integrating cell-type expression data generated by scRNA-seq and existing deconvolution methods. After benchmarking scMappR using RNA-seq data obtained from sorted blood cells, we asked if scMappR could reveal known cell-type specific changes that occur during kidney regeneration. We found that scMappR appropriately assigned DEGs to cell-types involved in kidney regeneration, including a relatively small proportion of immune cells. While scMappR can work with any user supplied scRNA-seq data, we curated scRNA-seq expression matrices for ∼100 human and mouse tissues to facilitate its use with bulk RNA-seq data alone. Overall, scMappR is a user-friendly R package that complements traditional differential expression analysis available at CRAN.</p>
Cerebellar Purkinje cells can differentially modulate coherence between sensory and motor cortex depending on region and behavior
<p>Dataset belonging to "Cerebellar Purkinje cells can differentially modulate coherence between sensory and motor cortex depending on region and behavior" (https://doi.org/10.1073/pnas.2015292118)</p>
Differential analysis of binarized single-cell RNA sequencing data captures biological variation
<p>Processed datasets used for binary differential analysis experiments.</p>
Data from: Cell cycle-dependent differentiation dynamics balances growth and endocrine differentiation in the pancreas
Organogenesis relies on the spatiotemporal balancing of differentiation and proliferation driven by an expanding pool of progenitor cells. In the mouse pancreas, lineage tracing at the population level has shown that the expanding pancreas progenitors can initially give rise to all endocrine, ductal, and acinar cells but become bipotent by embryonic day 13.5, giving rise to endocrine cells and ductal cells. However, the dynamics of individual progenitors balancing self-renewal and lineage-specific differentiation has never been described. Using three-dimensional live imaging and in vivo clonal analysis, we reveal the contribution of individual cells to the global behaviour and demonstrate three modes of progenitor divisions: symmetric renewing, symmetric endocrinogenic, and asymmetric generating a progenitor and an endocrine progenitor. Quantitative analysis shows that the endocrine differentiation process is consistent with a simple model of cell cycle–dependent stochastic priming of progenitors to endocrine fate. The findings provide insights to define control parameters to optimize the generation of β-cells in vitro.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.