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1,304
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Dataset results
1,304 results for “Cognitive impairments”
ENgaging in Advance Care Planning Talks Group Visit Intervention for Cognitive Impairment
ClinicalTrials.gov study NCT03711396. IPD Sharing: NO. Countries: 1. Publications: 3.
Metformin in Amnestic Mild Cognitive Impairment
ClinicalTrials.gov study NCT00620191. IPD Sharing: NO. Countries: 1. Publications: 1.
Probiotic Impact on Cognitive Performance, and Metabolic Outcomes in Overweight Young Adults With Impaired Glucose Regulation
ClinicalTrials.gov study NCT07073781. IPD Sharing: YES. Countries: 1. Publications: 14.
Memory Training Versus Yogic Meditation Training in Older Adults With Mild Cognitive Impairment
ClinicalTrials.gov study NCT01983930. IPD Sharing: NO. Countries: 1. Publications: 1.
A 3 Year Study to Evaluate the Safety and Efficacy of Low Dose Ladostigil in Patients With Mild Cognitive Impairment
ClinicalTrials.gov study NCT01429623. IPD Sharing: Not stated. Countries: 3. Publications: 3.
mSIM: Mobile Simultaneous Aerobic Exercise and Memory Training Intervention for Amnestic Mild Cognitive Impairment
ClinicalTrials.gov study NCT04185298. IPD Sharing: Not stated. Countries: 1. Publications: 48.
Semantic Memory, Financial Capacity, and Brain Perfusion in Mild Cognitive Impairment (MCI) (CASL)
ClinicalTrials.gov study NCT00880555. IPD Sharing: NO. Countries: 1. Publications: 3.
Effect of IVIG on Cerebral and Retinal Amyloid in Mild Cognitive Impairment Due to Alzheimer Disease
ClinicalTrials.gov study NCT03319810. IPD Sharing: NO. Countries: 1. Publications: 1.
Mild Cognitive Impairment and Obstructive Sleep Apnea
ClinicalTrials.gov study NCT01482351. IPD Sharing: YES. Countries: 1. Publications: 21.
Unified Barlow Protocol (UP) in Cancer Survivors for Cognitive Impairments
ClinicalTrials.gov study NCT05289258. IPD Sharing: NO. Countries: 1. Publications: 1.
Galantamine and Memantine Combination for Cognitive Impairments in Schizophrenia
ClinicalTrials.gov study NCT02234752. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Study to Assess Safety and Target Engagement of E2814 in Participants With Mild to Moderate Cognitive Impairment Due to Dominantly Inherited Alzheimer's Disease
ClinicalTrials.gov study NCT04971733. IPD Sharing: YES. Countries: 2. Publications: 0.
Managing Pain and Cognitions in Older Adults With Mild Cognitive Impairment or Memory Related Problems and Chronic Pain
ClinicalTrials.gov study NCT04044183. IPD Sharing: NO. Countries: 1. Publications: 2.
DNA methylation manipulation of memory genes is involved in sevoflurane induced cognitive impairments in aged rats
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Data from: Surgery impairs glymphatic activity and cognitive function in aged mice
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Data from: Profile of and risk factors for post-stroke cognitive impairment in diverse ethno-regional groups
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PAK3 downregulation induces cognitive impairment following cranial irradiation
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Data from: The subcortical basis of outcome and cognitive impairment in TBI: a longitudinal cohort study
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Dataset for research: "MTA and Koedam Score Contributes to Cognitive Impairment in Probable Alzheimer, Vascular and Mixed Dementia: A Memory Clinic Study in Indonesia"
<p>This is a dataset for research : "MTA and Koedam Score Contributes to Cognitive Impairment in Probable Alzheimer, Vascular and Mixed Dementia: A Memory Clinic Study in Indonesia"</p> <h1><strong><span>Abstract</span></strong></h1> <p><strong><span>Background</span></strong><span>. Medial Temporal Atrophy (MTA) and Parietal Atrophy (Koedam score) have been used in clinical practice to help the diagnosis of Alzheimer’s disease. However, the role of this brain imaging marker in early detection of other type of dementia remains elusive. The study aims to investigate the association between MTA and Koedam scores with the cognitive function in dementia patients (Alzheimer, vascular and mixed dementia).</span></p> <p><strong><span>Method</span></strong><span> <span>This was a</span> cross-sectional study using<span> data from a</span> Memory Clinic in Dr. Sardjito General Hospital Yogyakarta, Indonesia. The data was collected from January 2020 until December 2022. We collected the data regarding demographic and clinical characteristics, including head MRI data and Montreal Cognitive Assessment (MoCA) score. The cut-off points of MTA score and Koedam score were determined by using Receiver Operating Curve (ROC) and Youden Index. Multivariate analysis was performed to investigate variables which were associated with the cognitive function. </span></p> <p><strong><span>Result </span></strong><span>From 61 dementia patients, 22.95% was probable Alzheimer’s disease, 59.01% was vascular dementia, and 18.03% was mixed dementia. Correlation test showed that MTA and Koedam score were negatively associated with Montreal Cognitive Assessment-Indonesian Version (MoCA-INA) score. A bivariate analysis supports the findings that patients with combination of MTA score ≥3 and Koedam score ≥2 was more likely to have poor cognitive function (OR= 11.33; p<0.05). Multivariate analysis showed higher MTA (≥3) and Koedam (≥2) scores were associated with poor cognitive function in dementia patients (OR= 13.54, 95% CI= 1.77-103.43, <em>p</em>=0.01 and OR= 5.52, 95% CI= 1.08-28.19, <em>p</em>=0.04)</span></p> <p><strong><span>Conclusion </span></strong><span>Higher MTA and Koedam score contribute to worse cognitive function in any type of dementia patients. </span></p> <p><strong><span>Keywords.</span></strong><span> Imaging Marker, Medial Temporal Atrophy (MTA), Koedam Score, Cognitive Function, Dementia</span></p>
JNK Activation Correlates with Cognitive Impairment and Alteration of the Post-Synaptic Element in the 5xFAD AD Mouse Model
<p>The c-Jun N-terminal kinases (JNKs) are a family of proteins that, once activated by stress<br>stimuli, can alter neuronal functions and survival. The JNK cascade plays a crucial role in the<br>post-synaptic neuronal compartment by altering its structural organization and leading, at worst,<br>to an overall impairment of neuronal communication. Increasing evidence suggests that synaptic<br>impairment is the first neurodegenerative event in Alzheimer’s disease (AD). To better elucidate this<br>mechanism, we longitudinally studied 5xFAD mice at three selected time points representative of<br>human AD symptom progression. We tested the mice cognitive performance by using the radial<br>arm water maze (RAWM) in parallel with biochemical evaluations of post-synaptic enriched protein<br>fraction and total cortical parenchyma. We found that 5xFAD mice presented a strong JNK activation<br>at 3.5 months of age in the post-synaptic enriched protein fraction. This JNK activation correlates<br>with a structural alteration of the post-synaptic density area and with memory impairment at this<br>early stage of the disease that progressively declines to cause cell death. These findings pave the way<br>for future studies on JNK as a key player in early neurodegeneration and as an important therapeutic<br>target for the development of new compounds able to tackle synaptic impairment in the early phase<br>of AD pathology</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.