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282 results for “Data Deficient”
data set related to article Brain mitochondrial proteome alteration driven by creatine deficiency suggests novel therapeutic venues for creatine deficiency syndromes
<p>This record contains raw data related to article Brain mitochondrial proteome alteration driven by creatine deficiency suggests novel therapeutic venues for creatine deficiency syndromes</p>
Data from: Hybrid chickadees are deficient in learning and memory
Identifying the phenotypes underlying postzygotic reproductive isolation is crucial for fully understanding the evolution and maintenance of species. One potential postzygotic isolating barrier that has rarely been examined is learning and memory ability in hybrids. Learning and memory are important fitness-related traits, especially in scatter-hoarding species, where accurate retrieval of hoarded food is vital for winter survival. Here, we test the hypothesis that learning and memory ability can act as a postzygotic isolating barrier by comparing these traits among two scatter-hoarding songbird species, black-capped (Poecile atricapillus), Carolina chickadees (Poecile carolinensis), and their naturally occurring hybrids. In an outdoor aviary setting, we find that hybrid chickadees perform significantly worse on an associative learning spatial task and are worse at solving a novel problem compared to both parental species. Deficiencies in learning and memory abilities could therefore contribute to postzygotic reproductive isolation between chickadee species. Given the importance of learning and memory for fitness, our results suggest that these traits may play an important, but as yet overlooked, role in postzygotic reproductive isolation.
Data from: Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents development of atherosclerosis in high-fat diet-fed apoE-deficient mice via ameliorating hyperlipidemia, pro-inflammatory mediators and oxidative responses
Pantoea agglomerans (P. agglomerans) is a Gram-negative bacterium that grows symbiotically with various edible plants, and the oral or sublingual administration of lipopolysaccharide derived from P. agglomerans (LPSp) have been suggested to contribute to prevention of immune-related diseases. Our previous study indicated that orally administered LPSp was shown to exhibit an LDL-lowering effect in hyperlipidemic volunteers; however, a preventive effect of LPSp on atherosclerosis is unclear. The present study attempted to evaluate the anti-atherosclerotic effect by LPSp in a mouse model of high-fat diet (HFD)-induced atherosclerosis. For 16 weeks, apoE-deficient mice were fed an HFD and received drinking water containing LPSp (0.3 or 1 mg/kg body weight/day). The results showed that the orally administered LPSp decreased body weight. A significant reduction in atherosclerotic plaque deposition was observed even with the lower dose of LPSp. The biochemical analyses showed that LPSp markedly improved glucose tolerance and reduced plasma LDL and oxidized LDL levels. In addition, LPSp significantly reduced the production of pro-inflammatory mediators including MCP-1 (in the plasma), TNF-α and IL-6 (in the colon), and decreased the oxidative burst activities in the peripheral blood sample. Taken together, these results suggest the possibility that oral administration of LPSp can effectively ameliorate HFD-induced hyperlipidemia and inflammatory/oxidative responses to prevent atherosclerosis and related metabolic disorders.
Data from: Sensory deficiencies affect resources selection and associational effects at two spatial scales
Many insect species have limited sensory abilities and may not be able to perceive the quality of different types of resources while approaching patchily distributed resources. These restrictions may lead to differences in selection rates between separate patches and between different resource types within a patch, which may have consequences for associational effects between resources. In this study, we used an oviposition assay containing different frequencies of apple and banana substrates divided over two patches to compare resource selection rates of wild type Drosophila melanogaster at the between and within patch scales. Next, we compared the wild type behavior with that of the olfactory deficient strain Orco2, and the gustatory deficient strain PoxnΔM22-B5 and found comparable responses to patch heterogeneity and similarly strong selection rates for apple at both scales for the wild type and olfactory deficient flies. Their oviposition behavior translated into associational susceptibility for apple and associational resistance for banana. The gustatory deficient flies, on the other hand, no longer had a strong selection rate for apple, strongly differed in between and within patch selection rates from the wild type flies, and caused no associational effects between the resources. Our study suggests that differences in sensory capabilities can affect resource selection at different search behavior scales in different ways, and in turn underlie associational effects between resources at different spatial scales.
Figure 2 from: Stoimenova A, Kirilov B, Zaykova K (2019) Analysis of good distribution practice inspection deficiency data of pharmaceutical wholesalers in Bulgaria. Pharmacia 66(3): 85-89. https://doi.org/10.3897/pharmacia.66.e35880
Figure 2 No of suspended wholesale authorizations 2009–2018.
Figure 1 from: Stoimenova A, Kirilov B, Zaykova K (2019) Analysis of good distribution practice inspection deficiency data of pharmaceutical wholesalers in Bulgaria. Pharmacia 66(3): 85-89. https://doi.org/10.3897/pharmacia.66.e35880
Figure 1 Number of authorizations issued 2007–2018.
Data from: Saposin B deficiency as a cause of adult-onset metachromatic leukodystrophy
N/A
A Retrospective, Observational, Noninterventional Data Collection Study for Patients With Molybdenum Cofactor Deficiency Who Have Been Previously Treated With Cyclic Pyranopterin Monophosphate (cPMP)
ClinicalTrials.gov study NCT01640717. IPD Sharing: Not stated. Countries: 6. Publications: 0.
Retrospective Study to Capture Dosing and Treatment Outcome Data in Participants With Severe Congenital Protein C Deficiency Who Were Treated With Protein C Concentrate Under an Emergency Use IND
ClinicalTrials.gov study NCT00161720. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Expression data from control or conditional Oc-deficient embryonic motor neurons
GEO Series GSE141949. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
aCGH data of Rb/p53 deficient mammary tumors
GEO Series GSE62101. Mus musculus. 9 samples. Type: Genome variation profiling by genome tiling array.
Functional genomic analysis of frataxin deficiency, Illumina data
GEO Series GSE15848. Mus musculus. 22 samples. Type: Expression profiling by array.
Data from: Oral administration of Pantoea agglomerans-derived lipopolysaccharide prevents development of atherosclerosis in high-fat diet-fed apoE-deficient mice via ameliorating hyperlipidemia, pro-inflammatory mediators and oxidative responses
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Data from: Interplanting annual ryegrass, wheat, oat, and corn to mitigate iron deficiency in dry beans
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Data from: Hybrid chickadees are deficient in learning and memory
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Data from: Cd36-deficient congenic strains show improved glucose tolerance and distinct shifts in metabolic and transcriptomic profiles
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Data from: Selected HLA-B allotypes are resistant to inhibition or deficiency of the transporter associated with antigen processing (TAP)
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Data from: Genome-Wide Analyses Suggest Mechanisms Involving Early B-Cell Development in Canine IgA Deficiency
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Data from: Saposin B deficiency as a cause of adult-onset metachromatic leukodystrophy
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Data from: Landscape of tumor mutation load, mismatch repair deficiency, and PD-L1 expression in a large patient cohort of gastrointestinal cancers
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.