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233
datasets available to search
ShareScore release 0.9.0
Dataset results
233 results for “Diastole”
Therapeutic Approach to Diastolic Dysfunction in Chronic Liver Disease Patients and Its Impact on Morbidity and Mortality
ClinicalTrials.gov study NCT02294292. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of Dynamic Hyperinflation on the Left-ventricular Diastolic Function in Healthy Male Subjects
ClinicalTrials.gov study NCT03500822. IPD Sharing: Not stated. Countries: 1. Publications: 9.
Optimizing Exercise Training in Prevention and Treatment of Diastolic Heart Failure
ClinicalTrials.gov study NCT02078947. IPD Sharing: Not stated. Countries: 2. Publications: 7.
CORolla™ TAA for Heart Failure and Preserved Ejection Fraction and Diastolic Dysfunction
ClinicalTrials.gov study NCT01956526. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Left Ventricular Diastolic Dysfunction in Kidney Recipients
ClinicalTrials.gov study NCT02322567. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Effect of Eplerenone and Atorvastatin on Markers of Collagen Turnover in Diastolic Heart Failure
ClinicalTrials.gov study NCT00505336. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pulsatile and Steady State Hemodynamics in Diastolic Heart Failure
ClinicalTrials.gov study NCT00720525. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Impact of Pacing Mode and Diastolic Function on Cardiac Output
ClinicalTrials.gov study NCT04068233. IPD Sharing: NO. Countries: 1. Publications: 1.
Prognostic Assessment of Diastolic and Systolic Left Ventricular Function in Septic Shock
ClinicalTrials.gov study NCT02918214. IPD Sharing: NO. Countries: 1. Publications: 1.
Diastolic Dysfunction and Interstitial Lung Edema in Septic Patients
ClinicalTrials.gov study NCT03768752. IPD Sharing: NO. Countries: 1. Publications: 7.
The Ubiquitin Ligase WWP1 Contributes to Shifts in Matrix Proteolytic Profiles and a Myocardial Aging Phenotype with Diastolic Heart Failure
<p><strong><em>Aims</em></strong>. Ubiquitylation is a key event that regulates protein turnover, and induction of the ubiquitin ligase E3 WWP1 has been associated with age. Left ventricular hypertrophy (LVH) commonly occurs as a function of age and can cause heart failure with a preserved ejection fraction (EF; HFpEF). We hypothesized that overexpression (O/E) of WWP1 in the heart would cause LVH as well as functional and structural changes consistent with the aging HFpEF phenotype.</p> <p><strong><em>Methods and Results.</em></strong> Global WWP1 O/E was achieved in mice (n=11) and echocardiography (40 MHz) performed to measure LV mass, EF, Doppler velocities (early-E, late/atrial-A), myocardial relaxation (E’), and isovolumetric relaxation time (IVRT) at 4, 6, and 8 weeks. Age matched wild type animals (n=15) were included as referent controls. LV EF was identical (60+1% vs 60+1%, p>0.90) with no difference in LV mass (67+3 vs 75+5, p>0.25) at 4 weeks. However, at 8 weeks of age, LV mass increased by over two-fold, E/A fell (impaired passive filling), and E/E’ was lower and IVRT prolonged (impaired LV relaxation) - all p<0.05. Collagen percent area increased by over two-fold and fibrillar collagen expression (rtPCR) by over 1.5 fold (p<0.05) with WWP1 O/E. WWP1 with an anti-WWP1 antibody could be identified in isolated cardiac fibroblasts with WWP1 increased by over two-fold in O/E fibroblasts (p<0.05).</p> <p><strong><em>Conclusion.</em></strong> Inducing WWP1 expression caused LVH, preserved systolic function, but impaired diastolic dysfunction, consistent with the HFpEF phenotype. Targeting the WWP1 pathway may be a novel therapeutic target for this intractable form of HF associated with aging.</p>
Regression of Fibrosis & Reversal of Diastolic Dysfunction in HFpEF Patients Treated With Allogeneic CDCs
ClinicalTrials.gov study NCT02941705. IPD Sharing: NO. Countries: 1. Publications: 0.
A Trial of Intravenous Calcium and Myocardial Diastolic Dysfunction During Separation From Cardiopulmonary Bypass
ClinicalTrials.gov study NCT00955266. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Impact of Sacubitril/Valsartan on LV Diastolic Function in HFrEF
ClinicalTrials.gov study NCT07157527. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Safety and Efficacy Trial to Treat Diastolic Heart Failure Using Ambrisentan
ClinicalTrials.gov study NCT00840463. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Estrogen Diastolic Heart Failure
ClinicalTrials.gov study NCT02693002. IPD Sharing: YES. Countries: 1. Publications: 0.
Effects of Statin Therapy on Vascular Properties and Outcomes in Diastolic Heart Failure Patients
ClinicalTrials.gov study NCT00585611. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Relationship Between Abnormal Myocardial Perfusion and Diastolic Dysfunction in Sickle Cell Disease Using PET
ClinicalTrials.gov study NCT05583721. IPD Sharing: YES. Countries: 1. Publications: 0.
Study of Ranolazine in the Treatment of Pulmonary Hypertension Associated With Diastolic Left Ventricular Dysfunction
ClinicalTrials.gov study NCT02133352. IPD Sharing: NO. Countries: 1. Publications: 0.
Perfusion Index and End Diastolic Velocity Ratios as Predictors of Supraclavicular Block Success in Vascular Access Surgery
ClinicalTrials.gov study NCT07197281. IPD Sharing: NO. Countries: 0. Publications: 1.
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OpenNeuro
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