Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
1,764
datasets available to search
ShareScore release 0.9.0
Dataset results
1,764 results for “ER”
Efficacy, Safety, and Tolerability of Levomilnacipran ER in Pediatric Patients (7-17 Years) With Major Depressive Disorder
ClinicalTrials.gov study NCT03569475. IPD Sharing: YES. Countries: 1. Publications: 1.
Phase 2 Window Study of SAR439859 (Amcenestrant) Versus Letrozole in Post-menopausal Patients With ER+, HER2- Pre-operative Post-menopausal Primary Breast Cancer
ClinicalTrials.gov study NCT04191382. IPD Sharing: YES. Countries: 9. Publications: 1.
Amcenestrant (SAR439859) Plus Palbociclib as First Line Therapy for Patients With ER (+) HER2(-) Advanced Breast Cancer
ClinicalTrials.gov study NCT04478266. IPD Sharing: YES. Countries: 30. Publications: 2.
Open-label, Phase II, Study of Everolimus Plus Letrozole in Postmenopausal Women With ER+, HER2- Metastatic or Locally Advanced Breast Cancer
ClinicalTrials.gov study NCT01698918. IPD Sharing: YES. Countries: 13. Publications: 1.
Phase 2 Study of Amcenestrant (SAR439859) Versus Physician's Choice in Locally Advanced or Metastatic ER-positive Breast Cancer
ClinicalTrials.gov study NCT04059484. IPD Sharing: YES. Countries: 23. Publications: 1.
Data from: Human atlastin-3 is a constitutive ER fusion catalyst (lipid mixing data)
Open the record for dataset details and reuse information.
Supporting data and software for: Low-temperature open-air synthesis of PVP-coated NaYF4:Yb,Er,Mn upconversion nanoparticles with strong red emission
Open the record for dataset details and reuse information.
Data for: Human atlastin-3 is a constitutive ER membrane fusion catalyst (phylogenetic and sequence analysis)
Open the record for dataset details and reuse information.
Data from: Characterization of rhizome transcriptome and identification of a rhizomatous ER body in the clonal plant Cardamine leucantha
<p>The rhizome is a plant organ that develops from a shoot apical meristem but penetrates into belowground environments. To characterize the gene expression profile of rhizomes, we compared the rhizome transcriptome with those of the leaves, shoots and roots of a rhizomatous Brassicaceae plant, <i>Cardamine leucantha.</i> Overall, rhizome transcriptomes were characterized by the absence of genes that show rhizome-specific expression and expression profiles intermediate between those of shoots and roots. Our results suggest that both endogenous developmental factors and external environmental factors are important for controlling the rhizome transcriptome. Genes that showed relatively high expression in the rhizome compared to shoots and roots included those related to belowground defense, control of reactive oxygen species, and cell elongation under dark conditions. A comparison of transcriptomes further allowed us to identify the presence of an ER body, a defense-related belowground organelle, in epidermal cells of the <i>C. leucantha </i>rhizome, which is the first report of ER bodies in rhizome tissue.</p>
Data from: Response to persistent er stress in plants: a multiphasic process that transitions cells from prosurvival activities to cell death
The unfolded protein response (UPR) is a highly conserved response that protects plants from adverse environmental conditions. The UPR is elicited by endoplasmic reticulum (ER) stress, in which unfolded and misfolded proteins accumulate within the ER. Here, we induced the UPR in maize (Zea mays) seedlings to characterize the molecular events that occur over time during persistent ER stress. We found that a multiphasic program of gene expression was interwoven among other cellular events, including the induction of autophagy. One of the earliest phases involved the degradation by regulated IRE1-dependent RNA degradation (RIDD) of RNA transcripts derived from a family of peroxidase genes. RIDD resulted from the activation of ZmIRE1 for promiscuous ribonuclease activity that attacks the mRNAs of secreted proteins. This was followed by an upsurge in expression of the canonical UPR genes indirectly driven by ZmIRE1 due to its splicing of Zmbzip60 to make an active transcription factor that directly upregulates many of the UPR genes. At the peak of UPR gene expression, a global wave of alternative RNA processing led to the production of many aberrant UPR gene transcripts, likely tempering the ER stress response. During later stages of ER stress, ZmIRE1's activity declined as did the expression of survival modulating genes, Bax inhibitor1 and Bcl-2-associated athanogene7, amidst a rising tide of cell death. Thus, in response to persistent ER stress, maize seedlings embark on a course of gene expression and cellular events progressing from adaptive responses to cell death.
Khirbet er-Ram, Area A
3D Model of Khirbet er-Ram, Area A. Data collected 13 November 2016 by Adam Prins. 3D Model by Matthew J. Adams. Source: Objaverse 1.0 / Sketchfab
Extended reference scenarios (ERS) file (including only the temperature and trace species climatology)
<p>Extended reference scenarios are store in a single NetCDF file providing the atmospheric state (pressure, temperature and composition) expected to be seen by CAIRT for different conditions (altitude, latitude, season, time, solar activity and volcanic activity). </p>
Castle O'er
Castle O'er hillfort, Dumfriesshire. Model created using SRSP ALS data under [Open Government Licence](http://www.nationalarchives.gov.uk/doc/open-government-licence/version/3/). Find out more about [Castle O'er at on Canmore](https://canmore.org.uk/site/67376/castle-oer). Source: Objaverse 1.0 / Sketchfab
Data for "Heat treatment and fiber drawing effect on the matrix structure and fluorescence lifetime of Er- and Tm-doped silica optical fibers"
<p>Includes data for absorption and attenuation measurements and calculations, profiles of refractive index and concentrations, TEM images, XRD patters, and data for fluorescence decay curves presented in the graphs.</p>
ER training dataset for live cell anatomy segmentation
Open the record for dataset details and reuse information.
Raw data for Hancock-Cerutti et. al. "ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling"
<p>Blot images and tabular data for Hancock-Cerutti et. al. "ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling"</p>
Hormone receptors AR, ER, PR and growth factor receptor Her-2 expression in oral squamous cell carcinoma: Correlation with overall survival, disease-free survival and 10-year survival in a high-risk population
<p>Oral squamous cell carcinoma (OSCC) comprises most of head and neck neoplasms and is one of the highest-ranking and lethal cancers in Pakistan due to prevailing mouth habits. Growth and hormonal receptors act as prognostic markers and targets for therapy in some cancers, but their application in OSCC is largely unexplored. This study aimed to evaluate the expression of growth and hormonal receptors in OSCC patients and correlate it with 10-year, overall and disease-free survival. To achieve this objective, immunohistochemistry for Her-2, AR, ER and PR was performed on 100 formalin-fixed paraffin-embedded primary OSCC specimens. Receptor expression was correlated with mouth habits and clinicopathological features and patient survival was analyzed using Kaplan-Meier method and Cox regression univariate analysis. We observed that in 100 patients, there were 57 males and 43 females. Immunopositive Her-2 expression was observed in 21% of patients, AR in 13%, ER in 3% and 0% for PR. Patients with betel quid/areca nut mouth habits had significantly absent Her-2 expression (P=0.035). Also, Her-2 negative patients were also negative for AR expression (P=0.002). Her-2 positive patients had poor 10-year survival (P=0.041). A trend of low survival and high recurrence rate was observed in AR positive patients, but this was not significant (P=0.072). No statistically relevant correlations were seen in the case of ER and PR. In conclusion, Her-2 may be a valuable marker for predicting long-term prognosis of OSCC patients.</p>
ER values of the targeted by-products as a function of their metallogenic family. The bold text highlights the most relevant metal association regarding the selected metallogenic families.
<p>This dataset is table 3 from the article "Predictive assessment of metallogenic signatures using the DataBase Querying (DBQ) method: A European application by Blandine Gourcerol *, Guillaume Bertrand, Laurent Bailly, Pauline Moreau, Isabelle Duhamel-Achin, Maxime Picault, Philippe Négrel</p> <p>DOI : https://doi.org/10.1016/j.gexplo.2022.106966</p>
Substrates and a novel component in hSnd2-dependent ER protein targeting
<p>Protein import into the endoplasmic reticulum (ER) is essential for about 30% of the human proteome. It involves targeting of precursor proteins to the ER and insertion into or translocation across the ER membrane. Furthermore, it relies on signals in the precursor polypeptides and components, which read the signals and facilitate their targeting to a protein-conducting channel in the ER membrane, the Sec61 complex. Compared to the SRP- and TRC-dependent pathways, little is known about the SRP-independent/SND pathway. Our aim was to identify additional components and characterize the client spectrum of the human SND pathway. The established strategy of combining depletion of the central hSnd2-component from HeLa cells with proteomic- and differential protein abundance-analysis was used. The SRP and TRC targeting pathways were analyzed in comparison. TMEM109 was characterized as hSnd3. Unlike SRP but similar to TRC, the SND clients are predominantly membrane proteins with N-terminal, central, or C-terminal targeting signals.</p>
Hairpin protein partitioning from the ER to Lipid Droplets involves major structural rearrangements
<div> <p>The project includes dataset from MD simulations and EPR measurements.</p> <p>Description of the MD simulation dataset:<br>-Data type: MD simulations of UBXD8 peptide at varying depths/conformations in POPC bilayer, POPC/Triolein:Cholesteryl oleate monolayer, and in Bilayer-Lipid droplet setup. <br>-Force fields: All-atom simulations were carried out using Charmm36 force field. The parameters for Triolein and Cholesteryl oleate are derived from Olarte et al., 2020 and were obtained from the corresponding authors of that publication. Coarse-grained simulations were carried out using Martini force field. <br>-Simulation Package: All simulations were carried out using GROMACS 2021 simulation package.<br>-File types: The uploaded files include structure files in PDB format, input parameter files (.mdp), topology (topol.top), and force field files.</p> </div> <div>Description of the EPR dataset:<br>- Data type: Experimental spectroscopic measurements, Easyspin simulation and analysis<br>- Files are with filename extensions: DSC, DAT<br>- Information on origin of the data:<br>- EPR spectroscopic measurements with filename extensions DSC and DTA.<br>- EPR spectroscopic simulation and analyses with filename extension m.<br>- EPR simulations were generated using Easyspin version 5.2.36 and Matlab version 23.2.0.2428915.<br>- X-band CW-EPR spectroscopic measurements were generated by EMX spectrometer equipped with ER4123D cavity produced by Bruker.</div>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.