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4,582 results for “Gene regulation”
HBV X protein induces p16 gene promoter methylation through up-regulating DNA methylation transferases DNMT1 and DNMT3A
<p><strong>Supplementary Table S1. Kruskal-Wallis test results.</strong></p> <p><strong>Supplementary Table S2. Dunn-test with Bonferroni adjustment as post-hoc comparison results</strong></p> <p><strong>Supplementary Table S3. Mann-Whitney U test results</strong></p> <p> </p>
HBV X protein induces p16 gene promoter methylation through up-regulating DNA methylation transferases DNMT1 and DNMT3A
<p>Supplementary figure 1. Prediction of CpG island through Metaprime; Supplementary Table S1. Kruskal-Wallis test results; Supplementary Table S2. Dunn-test with Bonferroni adjustment as post-hoc comparison results; Supplementary Table S3. Mann-Whitney U test results</p>
Transcriptional profiling of the response to starvation and fattening reveals differential regulation of autophagy genes in mammals
<p>Nutrient deprivation (starvation) induced by fasting and hypercaloric regimens are stress factors that can influence cell and tissue homeostasis in mammals. One of the key cellular responses to changes in nutrient availability is the cell survival pathway, autophagy. While there has been much research into the protein networks regulating autophagy, less is known about the gene expression networks involved in this fundamental process. Here, we applied a network algorithm designed to analyze omics datasets, to identify sub-networks that are enriched for induced genes in response to starvation. This enabled us to identify two prominent active modules composed of key stress-induced transcription factors, including members of the Jun, Fos, and ATF families, and the other comprising autophagosome sub-network genes, including ULK1. The results were validated in the brain, liver, and muscle of fasting mice. Moreover, differential expression analysis of autophagy genes in the brain, liver, and muscle of high-fat diet-exposed mice, showed significant suppression of GABARAPL1 in the liver. Finally, our data provide a resource that may facilitate the future identification of regulators of autophagy.</p>
Fig. 8 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 8. The changes of the relative expression of WRI1 (A), BCCP2 (B), FAD2 (C), FAD3 (D) genes encoding after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves. Multivariate data analyses of gene expression analysis under investigation.
Fig. 5 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 5. The changes of the relative band intensity of different types of glutathione S-transferase activity isoenzymes (GST, A) and GST activity (B), and glutathione peroxidase activity (GPX, C) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
Fig. 1 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 1. The average absorption per active reaction center (ABS/RC), the electron transport flux per active reaction center (ETo/RC), the flux of trapped exciton per active reaction center (TRo/RC), and the energy flow on the acceptor side of PSI ((Ro), The number of QA-reducing reaction centers per PSII antenna chlorophyll ((ΦPo/(1-ΦPo)), the efficiency with which a trapped exciton transfers an electron to the photosynthetic electron transfer chain ((ΨEo/(1-ΨEo)), the number of QA- reducing reaction centers per PSII antenna chlorophyll (γRC/(1-γRC)), the ratio of total dissipation to the number of active reaction centers (DIo/RC). The relative variable fluorescence intensity at J (VJ) and I step (VI), the performance index based on light absorption (PIABS), and the performance index (potential) for energy conservation from exciton to PSI and acceptor reduction (PItotal) were determined in A. thaliana leaves following treatment with rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦ C).
Fig. 7 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 7. The changes of monodehydroascorbate reductase activity (MDHAR, A), dehydroascorbate reductase activity (DHAR, B), ascorbate content (AsA, C), dehydroascorbate content (DHA, D), glutathione content (GSH, E), oxidized glutathione content (GSSG, F), AsA/DHA (G), GSH/GSSG (H) and GSH redox state (I) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
Fig. 4 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 4. The changes of the relative band intensity of different types of peroxidase isoenzymes (POX, A) and POX activity (B), relative band intensity of different types of NADPH oxidase isoenzymes (NOX, C) and NOX activity (D) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
Fig. 3 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 3. The changes of the relative band intensity of different types of superoxide dismutase isoenzymes (SOD, A) and SOD activity (B), the relative band intensity of different types of catalase isoenzymes (CAT, C) and CAT activity (D) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
Fig. 2 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 2. The changes of hydrogen peroxide content (H O, A), lipid peroxidation (TBARS content, B), histochemical staining for O • accumulation (C), histochemical 2 2 2 staining for H2O2 determination (D), histochemical staining for plasma membrane integrity (E) and histochemical staining for lipid peroxidation (F) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
Fig. 6 in Rosmarinic acid and hesperidin regulate gas exchange, chlorophyll fluorescence, antioxidant system and the fatty acid biosynthesis-related gene expression in Arabidopsis thaliana under heat stress
Fig. 6. The changes of the relative band intensity of different types of ascorbate glutathione isoenzymes (APX, A) and APX activity (B), and glutathione reductase activity (GR, C) after rosmarinic acid (RA, 100 μM) and/or hesperidin (HP, 100 μM) with/without heat stress (38 ◦C) in A. thaliana leaves.
Dataset of scientific article: "Effect of miR-34a on expression of clock and clock-controlled genes in human cancer DLD1 and Lovo cells with different backgrounds in respect to p53 functionality and 17β-estradiol-mediated regulation"
<p>The dataset includes "raw" data used for the calculation of gene expression, wound healing test, fluorescence intensity, and MTS test.</p> <p> </p>
Imaging files for: ACD15, ACD21, and SLN regulate accumulation and mobility of MBD6 to silence genes and transposable elements
<p>It's well known that DNA methylation is linked to gene silencing but the mechanisms of how proteins that bind the DNA methylation cause gene silencing remains unclear. We demonstrated that the novel MBD5/6 complex contains three chaperone proteins, called ACD15, ACD21, and SLN, which specifically mediate the gene silencing function. ACD15 and ACD21 bridge the interaction of SLN to MBD5 and/or MBD6 while also functioning to drive the accumulation of the MBD5/6 complex at CG methylation sites. We further discovered that SLN also regulates the accumulation of the MBD5/6 complex and regulates the turnover of all protein members once accumulated at meCG sites. </p> <p>To demonstrate these results we primarily used fluorescence, confocal microscopy using RFP tagged MBD6, YFP tagged ACD15, and CFP tagg ACD21 and SLN imaging the roots of <em>Arabidopsis thaliana</em>. We expressed these constructs either alone or together in multiple mutant lines including <em>mbd5 mbd6, acd15, acd21, acd15 acd21,</em> <em>sln, </em>and <em>acd15 acd21 </em><em>sln </em>mutant plants. We also truncated MBD6 to remove the C terminus, called the C term deletion, as well as a version of MBD6 lacking the C terminus but with the domain necessary for interaction with ACD15 added back (MBD6 plus StkyC). With these microscopy experiments, we were able to demonstrate the specificity of ACD15 for the StkyC domain, the function of the chaperone proteins, and linke protein accumulation with gene silencing.</p>
Gene-diet Interactions on Body Weight Regulation and Lifestyle Parameters.
ClinicalTrials.gov study NCT04699448. IPD Sharing: NO. Countries: 1. Publications: 2.
Rare Variation and Remote Gene Regulation of Osteoporosis Related Phenotypes in Han Chinesse
ClinicalTrials.gov study NCT04129671. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Studying the Distribution of Accessory Gene Regulator (Agr) Quorum Sensing System and the Prevalence of Linezolid and Mupirocin Resistance in Biofilm Producer/Non Producer Staphylococcus Aureus in Soh
ClinicalTrials.gov study NCT06291181. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Case Control Study to Identify the Role of Epigenetic Regulation of Genes Responsible for Energy Metabolism and Mitochondrial Function in the Obesity Paradox in Cardiac Surgery
ClinicalTrials.gov study NCT02908009. IPD Sharing: UNDECIDED. Countries: 1. Publications: 3.
Regulation of Blood-Brain Barrier Permeability by APOE Gene Polymorphism and Its Impact on Cognitive Function Post-Radiotherapy in Nasopharyngeal Carcinoma: an MRI Study
ClinicalTrials.gov study NCT06881225. IPD Sharing: NO. Countries: 1. Publications: 10.
Genes-in-Action - Hepcidin Regulation of Iron Supplementation
ClinicalTrials.gov study NCT03341338. IPD Sharing: NO. Countries: 1. Publications: 1.
Epigenetic Analysis of Regulation of the Inflammasome-activating NLRP3 Gene in Monocytes From Atrial Fibrillation Patients and Controls
ClinicalTrials.gov study NCT04766814. IPD Sharing: Not stated. Countries: 1. Publications: 25.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.