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Dataset results
90 results for “HIF-1α”
RORγ hijacks HIF-1α to promote peritoneal metastasis of gastric cancer.
GEO Series GSE206444. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
PRMT5 inhibition by SCR-6920 leads to downregulation of HIF-1α and exhibits synergistic antitumor activity with bevacizumab in ovarian cancer
GEO Series GSE261629. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
HIF-1α CUT&Tag binding profile reveals a multifaceted regulation of steroidogenesis
GEO Series GSE311437. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Lactylation of HIF-1α at K172 drives HIF1 complex assemble to promote hypoxia-induced immune evasion in esophageal squamous cell carcinoma [CUT&Tag]
GEO Series GSE315098. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Lactylation of HIF-1α at K172 drives HIF1 complex assemble to promote hypoxia-induced immune evasion in esophageal squamous cell carcinoma [ATAC-seq]
GEO Series GSE315099. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Effect of hypoxia on HIF-1α binding genes in SUM159 breast cancer cells with ChIP-Seq.
GEO Series GSE287168. Homo sapiens. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Reduced Treg suppressive function and HIF-1α expression in hypoxia
GEO Series GSE41999. Homo sapiens. 12 samples. Type: Expression profiling by array.
Gene expression profiling data following HIF-1α or HIF-2α knockdown in SW1353 cells
GEO Series GSE156565. Homo sapiens. 9 samples. Type: Expression profiling by array.
Human Sarcopenic Myoblasts Can Be Rescued by Pharmacological Reactivation of HIF-1α
<p>Cirillo F, Mangiavini L, La Rocca P, Piccoli M, Ghiroldi A, Rota P, Tarantino A, Canciani B, Coviello S, Messina C, Ciconte G, Pappone C, Peretti GM, Anastasia L. Human Sarcopenic Myoblasts Can Be Rescued by Pharmacological Reactivation of HIF-1α. Int J Mol Sci. 2022 Jun 26;23(13):7114. doi: 10.3390/ijms23137114. PMID: 35806119; PMCID: PMC9267002.</p> <p>Abstract</p> <p>Sarcopenia, an age-related decline in muscle mass and strength, is associated with metabolic disease and increased risk of cardiovascular morbidity and mortality. It is associated with decreased tissue vascularization and muscle atrophy. In this work, we investigated the role of the hypoxia inducible factor HIF-1α in sarcopenia. To this end, we obtained skeletal muscle biopsies from elderly sarcopenic patients and compared them with those from young individuals. We found a decrease in the expression of HIF-1α and its target genes in sarcopenia, as well as of <em>PAX7</em>, the major stem cell marker of satellite cells, whereas the atrophy marker MURF1 was increased. We also isolated satellite cells from muscle biopsies and cultured them in vitro. We found that a pharmacological activation of HIF-1α and its target genes caused a reduction in skeletal muscle atrophy and activation of <em>PAX7</em> gene expression. In conclusion, in this work we found that HIF-1α plays a role in sarcopenia and is involved in satellite cell homeostasis. These results support further studies to test whether pharmacological reactivation of HIF-1α could prevent and counteract sarcopenia.</p> <p> </p>
Gene expression profile of HIF-1α silenced or non-silenced human DCs stimulated with A. fumigatus under normoxic or hypoxic conditions
GEO Series GSE60729. Homo sapiens. 24 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.