Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
3,741
datasets available to search
ShareScore release 0.9.0
Dataset results
3,741 results for “Hormons”
Maternally-transferred thyroid hormones and life-history variation in birds
<p><span>1. In vertebrates, thyroid hormones (THs) play an important role in the regulation of growth, development, metabolism, photoperiodic responses and migration. Maternally transferred THs are important for normal early-phase embryonic development when embryos are not able to produce endogenous THs. Previous studies have shown that variation in maternal THs within the physiological range can influence offspring phenotype.</span></p> <p><span>2. Given the essential functions of maternal THs in development and metabolism, THs may be a mediator of life-history variation across species. </span></p> <p><span>3. We tested the hypothesis that differences in life histories are associated with differences in maternal TH transfer across species. Using birds as a model, we specifically tested whether maternally transferred yolk THs co-vary with migratory status, developmental mode, and traits related to pace-of-life (e.g. basal metabolic rate, maximum lifespan).</span></p> <p><span>4. We collected un-incubated eggs (n = 1-21 eggs per species, median = 7) from 34 wild and captive bird species across 17 families and 6 orders to measure yolk THs (both triiodothyronine, T3 and thyroxine, T4), compiled life-history trait data from the literature, and used Bayesian phylogenetic mixed models to test our hypotheses.</span></p> <p><span>5. Our models indicated that both concentrations and total amounts of the two main forms of THs (T3 and T4) were higher in the eggs of migratory species compared to resident species, and total amounts were higher in the eggs of precocial species, which have longer prenatal developmental periods, than in those of altricial species. However, maternal yolk THs did not show clear associations with pace-of-life related traits, such as fecundity, basal metabolic rate, or maximum lifespan.</span></p> <p><span>6. We quantified interspecific variation in maternal yolk THs in birds and our findings suggest higher maternal TH transfer is associated with the precocial mode of development and migratory status. Whether maternal THs represent a part of the mechanism underlying the evolution of precocial development and migration or a consequence of such life histories is currently unclear. We therefore encourage further studies to explore the physiological mechanisms and evolutionary processes underlying these patterns.</span></p>
Hormone receptors AR, ER, PR and growth factor receptor Her-2 expression in oral squamous cell carcinoma: Correlation with overall survival, disease-free survival and 10-year survival in a high-risk population
<p>Oral squamous cell carcinoma (OSCC) comprises most of head and neck neoplasms and is one of the highest-ranking and lethal cancers in Pakistan due to prevailing mouth habits. Growth and hormonal receptors act as prognostic markers and targets for therapy in some cancers, but their application in OSCC is largely unexplored. This study aimed to evaluate the expression of growth and hormonal receptors in OSCC patients and correlate it with 10-year, overall and disease-free survival. To achieve this objective, immunohistochemistry for Her-2, AR, ER and PR was performed on 100 formalin-fixed paraffin-embedded primary OSCC specimens. Receptor expression was correlated with mouth habits and clinicopathological features and patient survival was analyzed using Kaplan-Meier method and Cox regression univariate analysis. We observed that in 100 patients, there were 57 males and 43 females. Immunopositive Her-2 expression was observed in 21% of patients, AR in 13%, ER in 3% and 0% for PR. Patients with betel quid/areca nut mouth habits had significantly absent Her-2 expression (P=0.035). Also, Her-2 negative patients were also negative for AR expression (P=0.002). Her-2 positive patients had poor 10-year survival (P=0.041). A trend of low survival and high recurrence rate was observed in AR positive patients, but this was not significant (P=0.072). No statistically relevant correlations were seen in the case of ER and PR. In conclusion, Her-2 may be a valuable marker for predicting long-term prognosis of OSCC patients.</p>
Prolactin and Lutenizing hormone levels during diestrus and proestrus in mice
<p>Prolactin secretion patterns are species-specific, variable and influenced by multiple factors including circadian and hormonal cues, stress, physiological state and reproductive strategy. In nonpregnant females, circulating prolactin levels are low; however, during the afternoon of proestrus an estradiol-induced prolactin surge coinciding with the preovulatory LH surge has been recorded in many (but not all) species. In mice, there have been conflicting reports relating to the occurrence and timing of this surge. To gain insight into the characteristics of circulating prolactin levels during proestrus we have used repeated tail tip blood sampling in C57BL/6J and Swiss Webster mice to profile prolactin secretion in individual mice. For this study we have measured prolactin levels during diestrus and proestrus using an ultra-sensitive prolactin ELISA. To establish the relationship between circulating prolactin levels and the timing of the LH surge we have simultaneously measured LH levels in the same samples via ELISA. In mice circulating prolactin levels in proestrus do not follow a classical surge pattern but show prolonged elevation which is not tightly linked to the light/dark cycle.</p>
Supplementary material (Sanger sequencing photo) of the case of THRB mosaicism presented in Clinically Symptomatic Resistance to Thyroid Hormone β Syndrome Because of THRB Gene Mosaicism of Donnars et al. (https://doi.org/10.1210/clinem/dgac347)
<p>Supplementary material (Sanger photo) of the case of THRB mosaicism presented in "Clinically Symptomatic Resistance to Thyroid Hormone β Syndrome Because of THRB Gene Mosaicism", by Donnars et al. (https://doi.org/10.1210/clinem/dgac347)</p>
Data for: Actions of Parathyroid hormone ligand analogs in humanized PTH1R knock-in mice
<p>Rodent models are commonly used to evaluate parathyroid hormone (PTH) and PTH-related protein (PTHrP) ligands and analogs for their pharmacologic activities and potential therapeutic utility towards diseases of bone and mineral ion metabolism. Divergence, however, in the amino acid sequences of rodent and human PTH receptors (rat and mouse PTH1Rs are 91% identical to the human PTH1R) can lead to differences in receptor-binding and signaling potencies for such ligands when assessed on rodent versus human PTH1Rs, as shown by cell-based assays in vitro. This introduces an element of uncertainty in the accuracy of rodent models for performing such pre-clinical evaluations. To overcome this potential uncertainty, we used a homologous recombination-based knock-in (KI) approach to generate a mouse (in host strain C57Bl/6N) in which cDNA encoding the human PTH1R replaces a segment (Exon 4) of the murine PTH1R gene such that the human and not the mouse PTH1R protein is expressed. Expression is directed by the endogenous mouse promoter and hence occurs in all biologically relevant cells and tissues and at appropriate levels. The resulting homozygous hPTH1R-KI (humanized) mice were healthy over at least ten generations and showed functional responses to injected PTH analog peptides that are consistent with a fully functional human PTH1R in target bone and kidney cells. The initial evaluation of these mice and their potential utility for predicting behavior of PTH analogs in humans is reported here. </p>
The metabolic hormone adiponectin affects the correlation between nutritional status and pneumococcal vaccine response in vulnerable indigenous children
<p class="MsoNoSpacing"><strong><span>Background:</span></strong><span> Almost 200 million children worldwide are either undernourished or overweight</span><span>. </span><span>Only a few studies have addressed the effect of variation in nutritional status on vaccine response</span><span>. </span><span>We previously demonstrated an association between stunting and an increased post-vaccination 13-valent pneumococcal conjugate vaccine (PCV13) response. In this prospective study, we assessed to what extent metabolic hormones may be a modifier in the association between nutritional status and PCV13 response.</span></p> <p class="MsoNoSpacing"><strong><span>Methods: </span></strong><span>Venezuelan children aged 6 weeks to 59 months were vaccinated with a primary series of PCV13. Nutritional status and serum levels of leptin, adiponectin and ghrelin were measured upon vaccination and their combined effect on serum post-vaccination antibody concentrations was assessed by generalized estimating equations multivariable regression analysis.</span></p> <p class="MsoNoSpacing"><strong><span>Results:</span></strong><span> A total of 210 children were included, of whom 80 were stunted, 81 had a normal weight and 49 were overweight. Overweight children had lower post-vaccination antibody concentrations than normal weight children </span><span>(regression coefficient -1.15, 95% CI -2.22 – -0.072)</span><span>. Additionally, there was a significant adiponectin-nutritional status interaction. In stunted children, higher adiponectin serum concentrations were associated with lower post-PCV13 antibody concentrations </span><span>(regression coefficient -0.19, 95% CI -0.24 – -0.14) </span><span>while the opposite was seen in overweight children </span><span>(regression coefficient 0.14, 95% CI 0.049 – 0.22)</span><span>. </span></p> <p><strong><span>Conclusion:</span></strong><span> Metabolic hormones, in particular adiponectin, may modify the effect of nutritional status on pneumococcal vaccine response. These findings emphasize the importance of further research to better understand the immunometabolic pathways underlying vaccine response and enable a future of optimal personalized vaccination schedules.</span></p>
Assessing PATL2 as a Non-hormonal Contraceptive Target
<p>PATL2 is an RNA-binding, translation repressing protein involved in the female reproductive system. In this article, we discuss the need for non-hormonal contraceptives, the viability of PATL2 as a protein target, as well as work completed and in progress to characterize PATL2.</p>
Characterization and Assessment of KCNU1/SLO3 as a Potential Non-hormonal Contraceptive Target
<p>The Structural Genomics Consortium (SGC) has recently embarked on its first research project in reproductive biology as a part of the SGC’s new open science Women’s and Children’s Health Program (WCHP). This program, which was generously funded by the Bill & Melinda Gates Foundation will focus on drug discovery for childhood diseases and development as well as reproductive biology and disease. One of the first initiatives of WCHP is to identify and characterize protein targets for non-hormonal contraceptive agents.</p> <p>Although most contraceptive strategies have focused on the female reproductive system, there is great interest in developing contraceptives for the male reproductive system. Ion channels in sperm are of interest as viable targets for non-hormonal contraceptives for several reasons. First, they are promising drug targets due to their involvement in various pathophysiologies as well as their roles in sperm capacitation and the acrosomal reaction. Second, they contain druggable sites at cell surfaces, and third, proteins that respond to ion signaling are essential to sperm cells which must adapt to changing environments and respond to cues from the female reproductive tract. It is worth noting that approximately 15% of current drug targets are ion channels. One potential target is potassium/calcium-activated channel subfamily U member I (KCNU1), sometimes referred to as SLO3, a potassium channel that is expressed solely in mammalian sperm<span>. </span>In this work, we will describe our efforts to characterize KCNU1 as a potential protein target for non-hormonal contraceptives.</p>
Unravelling the role of thyroid hormones in seasonal neuroplasticity in European Starlings (Sturnus vulgaris)
<p class="MsoNormal">Thyroid hormones clearly play a role in the seasonal regulation of reproduction, but any role they might play in song behavior and the associated seasonal neuroplasticity in songbirds remains to be elucidated. To pursue this question, we first established seasonal patterns in the expression of thyroid hormone regulating genes in male European starlings employing in situ hybridization methods. Thyroid hormone transporter LAT1 expression in the song nucleus HVC was elevated during the photosensitive phase, pointing towards an active role of thyroid hormones during this window of possible neuroplasticity. In contrast, DIO3 expression was high in HVC during the photostimulated phase, limiting the possible effect of thyroid hormones to maintain song stability during the breeding season. Next, we studied the effect of hypothyroidism on song behavior and neuroplasticity using i<em>n vivo </em>MRI. Both under natural conditions as with methimazole treatment, circulating thyroid hormone levels decreased during the photosensitive period, which coincided with the onset of neuroplasticity. This inverse relationship between thyroid hormones and neuroplasticity was further demonstrated by the negative correlation between plasma T3 and the microstructural changes in several song control nuclei and cerebellum. Furthermore, maintaining hypothyroidism during the photostimulated period inhibited the increase in testosterone, confirming the role of thyroid hormones in activating the hypothalamic–pituitary–gonadal (HPG) axis. The lack of high testosterone levels influenced the song behavior of hypothyroid starlings, while the lack of high plasma T4 during photostimulation affected the myelination of several tracts. Potentially, a global reduction of circulating thyroid hormones during the photosensitive period is necessary to lift the brake on neuroplasticity imposed by the photorefractory period, whereas local fine-tuning of thyroid hormone concentrations through LAT1 could activate underlying neuroplasticity mechanisms. Whereas an increase in circulating T4 during the photostimulated period potentially influences the myelination of several white matter tracts, which stabilizes the neuroplastic changes. Given the complexity of thyroid hormone effects, this study is a steppingstone to disentangle the influence of thyroid hormones on seasonal neuroplasticity.</p>
Fig. 2 in Angiostrongylus cantonensis induces energy imbalance and dyskinesia in mice by reducing the expression of melanin-concentrating hormone
Fig. 2 (See legend on previous page.)
Dynamic Crosstalk Between Female Gonadal Hormones and Vaginal Microbiota Across Various Reproductive Phases
<p>Vaginal samples for 16S rRNA sequencing are collected from 150 healthy women across five reproductive phases: follicular phase, luteal phase, early pregnancy, lactation, and menopause, with 30 samples per group.</p>
Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial.
<p>The .csv file contains all the primary data for publication: <br> Chartoumpekis DV, Ziros PG, Chen JG, Groopman JD, Kensler TW, Sykiotis GP.<br> Broccoli sprout beverage is safe for thyroid hormonal and autoimmune status: Results of a 12-week randomized trial.<br> Food Chem Toxicol. 2019 Feb 5;126:1-6.<br> [Epub ahead of print] PubMed PMID: 30735751<br> doi: 10.1016/j.fct.2019.02.004.</p> <p>These data are used in all figures of the paper (Figure 1 and Figure 2).</p> <p>The data are tabular. The headers are the following:</p> <p>sample ID: It comprises 4 digits. The first 3 digits are the unique identifier of the subject in the trial, e.g., "613".<br> The last digit indicates whether the sample was collected at the start of the trial "0", or at the end of the trial "1".<br> E.g., "6130" is the sample collected from participant 613 at the beginning of the trial,<br> and 6131 is the sample collected from the same participant at the end of the trial.</p> <p>Autoimmunity: "0" means that both anti-TG and anti-TPO antibodies were within the reference range.<br> "1" means that either anti-TG, or anti-TPO antibodies, or both, were above the reference range.</p> <p>anti-TG (IU/ml): antibodies against thyroglobuline. The units are given in the parenthesis.</p> <p>anti-TPO (IU/ml): antibodies against thyropreoxidase. The units are given in the parenthesis.</p> <p>Treatment: "1"=placebo and "2"=broccoli sprouts extract beverage.</p> <p>Gender: "F" for female and "M" for male. Data from males were not included in the analyses.</p> <p>Age: In years.</p> <p><br> For any questions, contact: gerasimos.sykiotis@chuv.ch</p>
Data from: Variation in thyroid hormone levels is associated with elevated blood mercury levels among artisanal small-scale miners in Ghana
Background: Mercury can be very toxic to human health even at low dose of exposure. Artisanal small-scale miners (ASGMs) use mercury in gold production, hence are at risk of mercury-induced organ dysfunction. Aim: We determined the association between mercury exposure, thyroid function and work-related factors among artisanal small-scale gold miners in Bibiani-Ghana. Method: We conveniently recruited 137 consenting male gold miners at their work site in Bibiani-Ghana, in a comparative cross-sectional study. Occupational activities and socio-demographic data of participants were collected using a questionnaire. Blood sample was analysed for total mercury and thyroid hormones. Results: Overall, 58.4% (80/137) of the participants had blood mercury exceeding the occupational exposure threshold (blood mercury ≥5μg/L). T3(P<0.0001) and T4(P<0.0001) were significantly reduced among the exposed group compared to the non-exposed. TSH showed no significant variation between the exposed and non-exposed groups. Longer work duration (≥5years), gold amalgamation, gold smelting and sucking of excess mercury with the mouth were associated with increased odds of mercury exposure. Blood mercury showed negative correlation with T3(r = -0.29, P<0.0001), and T4(r = -0.69, P<0.0001) and positive correlation with work duration (r = 0.88, P<0.001). Even though a positive trend of association between blood mercury and TSH levels was recorded, it was not significant (r = 0.07, P = 0.4121). Conclusion: Small scale miners in Bibiani are exposed to mercury above the occupational threshold which may affect thyroid hormone levels.
Data of "Poor repeatability of cortisol responses to adrenocorticotropic hormone (ACTH) in beef heifers: is the ACTH challenge a suitable measure for stress research in cattle?"
<p>Data for article "Poor repeatability of cortisol responses to adrenocorticotropic hormone (ACTH) in beef heifers: is the ACTH challenge a suitable measure for stress research in cattle?" Dataset of 64 crossbred beef heifers which were subjected to three ACTH challenges. Both experimental independent variables (animal id, horn status, replicate, time of day of the ACTH challenge, ACTH challenge number) and post-ACTH salivary cortisol concentrations (at the seven sampling timepoints and area under the curve values) are presented.</p>
Data for: Compensating for a stressful pregnancy? Glucocorticoid treatment during gravidity reduces metabolic rate in female fence lizards post-parturition (In press: Hormones and Behavior)
<p>This dataset accompanies the paper "Compensating for a stressful pregnancy? Glucocorticoid treatment during gravidity reduces metabolic rate in female fence lizards post-parturition" (In press: Hormones and Behavior). A READ_ME/metadata explanation is available in Sheet 1. Address any queries to Dr. K. MacLeod, kirstyjmacleod@gmail.com.</p> <p>Abstract: Reproduction is a critical part of an animal’s life history, but one which incurs significant costs to survival and future reproductive potential. These physiological consequences are likely to be influenced by context – for example, if an individual is subject to environmental stressors, physiological and behavioral changes associated with reproduction may be altered. Glucocorticoids, hormones produced as part of the physiological response to stressors, may alter how reproduction affects female physiology and behavior, and therefore the outcomes of reproductive trade-offs. Glucocorticoids prioritize immediate survival over reproduction, for example through changes in immune function, metabolic rate, and foraging, which may reduce energy expenditure or increase energy gain. However, we previously found that female eastern fence lizards (<em>Sceloporus undulatus</em>) experiencing elevated glucocorticoid levels during gestation were nevertheless able to maintain reproductive output and body condition. Here we investigate compensatory mechanisms by which eastern fence lizard females may maintain reproduction under experimental increases in a glucocorticoid, corticosterone (CORT). We found that, although CORT-treated females had similar immune function and behavior, they had reduced metabolic rates 3-5 days post-parturition compared to control females. Given that CORT-treated females spent a similar time basking and had equal food intake compared to control females, we suggest that the reduced metabolic rate is a mechanism by which CORT-treated females maintain their energy balance and reduce the energetic costs of gestation during periods of stress. This study suggests that physiological responses to reproduction may be context-dependent and could act to minimize costs of reproduction in situations where CORT is elevated (such as during periods of environmental stress). </p>
Dataset of iodine manipulation and thyroid hormone production
<p>This is the dataset of an experiment conducted on Rock pigeons (<em>Columba livia</em>) in which we restricted dietary iodine in breeding females. With this experiment we tested whether iodine availability could limit thyroid hormone production and deposition in the eggs. This dataset contains all the responses measured in this experiment.</p>
Juvenile hormone regulates the photoperiodic plasticity of elytra coloration in a ladybird Harmonia axyridis
<p><span>Many animals, including insects, exhibit plasticity of body color in response to environmental changes</span><span>. Varied expression of c</span><span>arotenoids, major cuticle pigments, significantly contributes to body color flexibility. However, the molecular mechanisms by which environmental cues regulate carotenoid expression remain largely unknown. In this study, we used the ladybird <em>Harmonia axyridis</em> as a model to investigate the photoperiodic-responsive plasticity of elytra coloration and its endocrine regulation. It was found that <em>H. axyridis</em> females under long-day conditions develop elytra that are much redder than those under short-day conditions, resulting from the differential accumulation of carotenoids. Exogenous hormone application and RNAi-mediated gene knockdown indicate that carotenoid deposition was directed through the juvenile hormone (JH) receptor-mediated canonical pathway. Moreover, we characterized an SR-BI/CD36 (SCRB) gene <em>SCRB10</em> as the carotenoid transporter responding to JH signaling and regulating the elytra coloration plasticity. Taken together, we propose that JH signaling transcriptionally regulates the carotenoid transporter gene for the photoperiodic coloration plasticity of elytra in the beetles, which reveals a novel role of the endocrine system in the regulation of carotenoid-associated animal body coloration under environmental stimuli.</span></p>
Data for: Isolation of targeted hypothalamic neurons for studies of hormonal, metabolic, and electrical regulation
<p>All original data used in the study published in the Journal of Visualized Experiments entitled: "Isolation of Targeted Hypothalamic Neurons for Studies of Hormonal, Metabolic, and Electrical Regulation" by Kathera-Ibarra-Forzisi et al. are provided in this dataset. </p> <p>Data are organized in sub-folders containing either confocal or bright-field images of primary hypothalamic neurons. The dataset does not contain analyses or measurements. For each figure of the paper, the data are organized in sub-folders corresponding to a specific experimental condition. The sub-folders are labeled with the corresponding figure number and the salient experimental conditions. For example, the sub-folder labeled "confocal images figure 3" contains all the original confocal images from which the representative images of the figure were chosen from. Likewise, the folder "LepR+ figure 3" contains all the images of neurons immunolabeled with LepR antibody. Data can be used by a third party for verification purposes but cannot be used for publication.</p> <p><em>Abstract of the study</em>: The hypothalamus regulates fundamental metabolic processes by controlling functions as varied as food intake, body temperature, and hormone release. As the functions of the hypothalamus are controlled by specific subsets of neuronal populations, the ability to isolate them provides a major tool for studying metabolic mechanisms. In this regard, the neuronal complexity of the hypothalamus poses exceptional challenges. For these reasons, new techniques, such as Magnetic-Activated Cell Sorting (MACS), have been explored. This paper describes a new application of magnetic-activated cell sorting (MACS) using microbead technology to isolate a targeted neuronal population from prenatal mice brains. The technique is simple and guarantees a highly pure and viable primary hypothalamic neuron culture with high reproducibility. The hypothalamus is gently dissociated, neurons are selectively isolated and separated from glial cells, and finally, using a specific antibody for a cell surface marker, the population of interest is selected. Once isolated, targeted neurons can be used to investigate their morphological, electrical, and endocrine characteristics and their responses in normal or pathological conditions. Furthermore, given the variegated roles of the hypothalamus in regulating feeding, metabolism, stress, sleep, and motivation, a closer look at targeted and region-specific neurons may provide insight into their tasks in this complex environment.</p>
Improving the mating competitiveness of male Anastrepha ludens (Diptera: Tephritidae) fruit flies by adding two juvenile hormone analogues
<p>Improving the mating competitiveness and survival of sterile males are direct means to increasing the effectiveness of the Sterile Insect Technique (SIT). Some insecticide growth regulators, such as the juvenile hormone analogue (JHA) Methoprene, have been used to improve the mating competitiveness of male tephritid flies by reducing their sexual maturation period. However, a decrease in the period of sexual maturation induces a reduction in survival. Here, we compared the effects of methoprene and Pyriproxyfen (PPF), another JHA, in <em>Anastrepha</em> <em>ludens</em> males. Pyriproxyfen is an insect growth regulator that exhibits higher disruption on insects’ methamorphosis than methoprene or than natural JH. . Both compounds were administered at two doses (0.05 and 0.1%) via the male diet immediately after emergence. Our results show that both Pyriproxyfen and methoprene reduced male sexual maturation. However, PPF-treated males exhibited a shorter maturation period and obtained more matings at a given age than methoprene-treated males . No significant differences were observed between the two PPF doses tested (0.05 and 0.10 %). Male survival was equally accelerated by the two compounds. Our results demonstrate that PPF can be used as a tool to improve the mating performance of sterile males.</p>
One Week Parathyroid Hormone-related Protein (PTHrP) IV Dose Escalation Study
ClinicalTrials.gov study NCT00580788. IPD Sharing: NO. Countries: 1. Publications: 27.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.