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3,223 results for “Human Study”
Source Data: No evidence for a common blood microbiome based on a population study of 9,770 healthy humans
<p>Source data for manuscript titled: 'No evidence for a common blood microbiome based on a population study of 9,770 healthy humans' (https://www.biorxiv.org/content/10.1101/2022.07.29.502098v1)</p>
Correlative study of liquid in human bone by 3D neutron microscopy and lab-based X-ray µCT
<p>X-ray (xray_data.tiff) and neutron microscopy (neutron_data.tiff) of the same piece of human cortical bone.</p> <p>Neutron data were collected at the neutron microscope at SINQ, PSI, Switzerland while the x-ray data were collected in house at an VERSA 620 X-ray microscope. </p> <p>The voxel size is in both case 2.7 µm</p>
Detecting ecological traps in human-altered landscapes: A case study of the thick-billed longspur nesting in croplands
<p>Conversion of the North American prairies to cropland remains a prominent threat to grassland bird populations. Yet, a few species nest in these vastly modified systems. The thick-billed longspur (<em>Rhynchophanes mccownii</em>) is an obligate grassland bird whose populations have declined 4% annually during the past 50 years. Thick-billed longspurs historically nested in recently disturbed or sparsely vegetated patches within native mixed-grass prairie, but observations of longspurs in spring cereal and pulse crop fields during the breeding season in northeastern Montana, USA suggest such fields also provide cues for habitat selection. Maladaptive selection for poor-quality habitat may contribute to ongoing declines in longspur populations, but information on thick-billed longspur breeding ecology in crop fields is lacking. We hypothesized that these crop fields may function as ecological traps; specifically, we expected that crop fields may provide cues for territory selection, but frequent human disturbance and increased exposure to weather and predators would have negative consequences for reproduction. To address this hypothesis, we compared measures of habitat selection (settlement patterns and trends in abundance) and productivity (nest density, nest survival, and number of young fledged) between crop fields and native grassland sites during 2020–21. Across both years, settlement patterns were similar between site types and occupancy ranged from 0.52 ± 0.17SE to 0.99 ± 0.01 on April 7 and 30, respectively. Early season abundance differed by year, and changes in abundance during the breeding season appeared to be associated with precipitation-driven vegetation conditions rather than habitat type. While an index of nest density was lower in crop than native sites, the number of young fledged per successful nest (2.9 ± 0.18SE) and nest survival (0.24 ± 0.03 SE; n=222 nests) were similar for crop and native sites. Collectively, the data did not support our ecological trap hypothesis: longspurs did not exhibit a clear preference for crop sites and reproductive output was not significantly reduced. Our results indicate that croplands may provide alternative breeding habitat within a human-dominated landscape.</p>
Data supporting "Machine Learning-based Modeling of Olfactory Receptors: Human OR51E2 as a Case Study"
<p>Simulation data and input files in support of the Manuscript:"Machine Learning-based Modeling of Olfactory Receptors: Human OR51E2 as a Case Study".<br> <br> The archive is organized in 6 different folders:</p> <p>1. <strong>7x7_rmsd</strong>, which contains a tcl script (to be run in VMD) to compute the 7x7 RMSD matrix (see Wang et al. J Struct. Bio, (2017)).<br> 2. <strong>a100_plumed</strong>, which contains PLUMED input files to compute A<sup>100 </sup>index on OR51E2 trajectories.<br> 3. <strong>initial_structures</strong>, which contains the 6 different conformation for hOR51E2 obtained by the different predictors in the pdb format.<br> 4. <strong>mdp_files</strong>, which contains the GROMACS mdp files to perform all the protocol described in the paper.<br> 5. <strong>topologies</strong>, which contains the 6 different topologies (in .top format) and the initial conformation (in .gro format) for the hOR51E2 embedded in the membrane and solvated.<br> 6. <strong>trajectories</strong>, which contains the 18 (6 systems, 3 replicas per system) different trajectories with the sodium in place close to D69<sup>2.50</sup> without solvent and ions (in .xtc format with a frame every 100 ps) and a reference conformation (in .gro format). Here we have also added the trajectory for the SwissModel-derived simulation without sodium ion in place, where we observed the ion binding. This last trajectory contains also solvent and ions, but with a lower printing frequency (1 ns).</p>
Rational Modification of Human Gut Microbial Metabolites by Dietary Resistant Starch in Patients After Allogeneic Hematopoietic Stem Cell Transplantation: A Prospective Feasibility Study
<p>We conducted a prospective longitudinal feasibility study in patients undergoing allo-HCT for hematological malignancies to test the hypothesis that defined and consistent administration of resistant starch will rationally modify intestinal microbiota dependent metabolites, particularly the short chain fatty acids (SCFA), such as butyrate. Ten adults undergoing human leukocyte antigen-matched, related-donor myeloablative allo-HCT were enrolled and received resistant potato starch (RPS) daily from day -7 to day 100 after allo-HCT. </p>
Video clips related to the paper "Humanoid facial expressions as a tool to study human behavior
<p>During the experiment, participants observed video-clips of the iCub robot performing a gentle or rude arm movement (giving request) with a happy or angry facial expressions.</p>
Results of the ISMRM 2020 joint Reproducible Research & Quantitative MR study groups reproducibility challenge on phantom and human brain T<sub>1</sub> mapping
<p>This dataset includes both raw data and processed T1 maps obtained from the 2020 challenge on inversion recovery T1 mapping organized by the International Society in Magnetic Resonance in Medicine (ISMRM) Reproducible Research Study Group (RRSG). For a comprehensive overview of the data distribution submitted for this challenge, please visit <a href="https://rrsg2020.db.neurolibre.org/">https://rrsg2020.db.neurolibre.org</a>. It's important to note that this dataset exclusively comprises ISMRM-NIST system phantom data.</p> <p>Dataset provided for NeuroLibre preprint. Author repo: https://github.com/rrsg2020/paper NeuroLibre fork:https://github.com/roboneurolibre/paper</p> <p>For details, please visit the corresponding <a href="https://github.com/neurolibre/neurolibre-reviews/issues/14">NeuroLibre technical screening.</a></p> <p><strong><a href="https://neurolibre.org">https://neurolibre.org</a></strong></p>
Data from: Human conjunctival transcriptome in Acanthamoeba keratitis: An exploratory study
<p>The host conjunctival transcriptome of 9 patients with <em>Acanthamoeba</em> keratitis (AK) is compared to the conjunctival transcriptome of 13 patients with keratitis and no identified pathogen. Pathway enrichment analysis identified thirty-six transcripts as most differentially expressed between patients with AK compared to patients with presumed sterile keratitis.</p>
GRACE: A Study to Compare the Effectiveness, Safety and Tolerability of PREZISTA (Darunavir)/Ritonavir by Gender and Race When Administered With Other Antiretroviral Medications in Human Immunodeficie
ClinicalTrials.gov study NCT00381303. IPD Sharing: Not stated. Countries: 3. Publications: 3.
BI 894999 First in Human Dose Finding Study in Advanced Malignancies
ClinicalTrials.gov study NCT02516553. IPD Sharing: YES. Countries: 6. Publications: 1.
Initial Chronic Human Validation Study: Subcutaneous Implantable Cardioverter Defibrillator (S-ICD) System
ClinicalTrials.gov study NCT00853645. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Phase I Study to Evaluate a Human Monoclonal Antibody (MAb) 10E8VLS Administered Alone or Concurrently With MAb VRC07-523LS Via Subcutaneous Injection in Healthy Adults
ClinicalTrials.gov study NCT03565315. IPD Sharing: NO. Countries: 1. Publications: 3.
Safety and Immunogenicity Study of a Candidate Tuberculosis Vaccine in Human Immunodeficiency Virus (HIV)-Positive Adults
ClinicalTrials.gov study NCT01262976. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Phase I Study of Quadrivalent Human Papilloma Virus (HPV) (Types 6, 11, 16, 18) Recombinant Vaccine in HIV-Infected and HIV-Negative Pre-Adolescents, Adolescents, and Young Adults
ClinicalTrials.gov study NCT00798265. IPD Sharing: YES. Countries: 1. Publications: 3.
A Study of Intra-thrombus Plasmin (Human) In Acute Peripheral Arterial Occlusion
ClinicalTrials.gov study NCT01222117. IPD Sharing: Not stated. Countries: 12. Publications: 1.
Safety, Tolerability and Immunogenicity Study of 3 Prime-boost Regimens for Ebola Vaccines Ad26.ZEBOV/MVA-BN-Filo in Healthy Adults, Children and Human Immunodeficiency Virus Positive (HIV+) Adults
ClinicalTrials.gov study NCT02564523. IPD Sharing: Not stated. Countries: 4. Publications: 3.
A First in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of a Intravenous (IV) Dose of GSK2831781 in Healthy Volunteers and Patients With Plaque Psoriasis
ClinicalTrials.gov study NCT02195349. IPD Sharing: YES. Countries: 2. Publications: 1.
First-in-human Single Ascending Dose Study of LNA043 in Patients Scheduled for Total Knee Replacement
ClinicalTrials.gov study NCT02491281. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids
ClinicalTrials.gov study NCT01222091. IPD Sharing: NO. Countries: 1. Publications: 16.
A Study of Heterologous Vaccine Regimen of Adenovirus Serotype 26 Mosaic4 Human Immunodeficiency Virus(Ad26.Mos4.HIV), Adjuvanted Clade C gp140 and Mosaic gp140 to Prevent HIV-1 Infection Among Cis-ge
ClinicalTrials.gov study NCT03964415. IPD Sharing: YES. Countries: 9. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.