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97
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ShareScore release 0.9.0
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97 results for “Keratitis”
Efficacy and Safety of Plasma Rich in Growth Factors (PRGF-Endoret) Eye-drops in the Treatment of Neurotrophic Keratitis
ClinicalTrials.gov study NCT02707120. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Phase II Study of STSP-0902 Ophthalmic Solution in Patients With Neurotrophic Keratitis
ClinicalTrials.gov study NCT06975748. IPD Sharing: Not stated. Countries: 1. Publications: 0.
To Evaluate the Efficacy and Safety of ZKY001 Eye Drops in the Treatment of Corneal Epithelial Defects Caused by Neurotrophic Keratitis
ClinicalTrials.gov study NCT07120308. IPD Sharing: NO. Countries: 1. Publications: 0.
The Prevalence of Hypoesthesia Related Keratitis in Ocular Graft Vs. Host Disease (GVHD) Patients
ClinicalTrials.gov study NCT04700657. IPD Sharing: NO. Countries: 1. Publications: 0.
Matrix Therapy And Bacterial Keratitis
ClinicalTrials.gov study NCT02016989. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Use of a Biological Lens of Amniotic Membrane (LV-Visio-AMTRIX) in the Treatment of Treatment-Resistant Keratitis
ClinicalTrials.gov study NCT05250583. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Investigation of the Microbiome of the Cornea in Microbial Keratitis
ClinicalTrials.gov study NCT04030403. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Pseudomonal Type Three Secretion System and Contact Lens Associated Microbial Keratitis
ClinicalTrials.gov study NCT01925846. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Trial to Evaluate the Efficacy And Safety of IVIEW-1201 In the Treatment of Fungal Keratitis
ClinicalTrials.gov study NCT06463678. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Tyrosine Hydroxylase Antibody Levels in Autoimmune Polyglandular Syndrome Type 1 Associated Keratitis
ClinicalTrials.gov study NCT04375852. IPD Sharing: NO. Countries: 0. Publications: 0.
Pattern of Microbial Keratitis in Assiut University Hospital
ClinicalTrials.gov study NCT07316244. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Open-label Trial to Evaluate Efficacy and Safety of rhNGF on Corneal Thickness Via AS-OCT in Neurotrophic Keratitis
ClinicalTrials.gov study NCT06411145. IPD Sharing: NO. Countries: 0. Publications: 0.
Early Amniotic Membrane Transplantation in Bacterial Keratitis
ClinicalTrials.gov study NCT02716883. IPD Sharing: NO. Countries: 0. Publications: 0.
Transcriptome data for bacterial and fungal keratitis compared to cadaver cornea
GEO Series GSE58291. Homo sapiens. 30 samples. Type: Expression profiling by array.
RNA-sequencing-based off-target analysis of allele-specific siRNA in keratitis-ichthyosis-deafness syndrome patient-derived keratinocytes
GEO Series GSE131709. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Virulence factor expression by Serratia marcescens during microbial keratitis is regulated by stress response protein GumB
GEO Series GSE155486. Serratia marcescens; Oryctolagus cuniculus. 12 samples. Type: Other.
Establishment of an Acanthamoeba keratitis mouse model
<p><em>Acanthamoeba castellanii</em> results in <em>Acanthamoeba</em> keratitis (AK), which occurs mainly in contact lens user with poor eye hygiene. The findings of many <em>in vitro</em> studies of AK, especially the development of therapeutic drugs, need to be confirmed by <em>in vivo</em> experiments. For the establishment of an AK mouse model, in this study, <em>A. castellanii</em> cell suspensions (equal mixtures of trophozoites and cysts) were loaded onto 2-mm contact lens pieces to be inserted into mouse eyes that were scratched using an ophthalmic surgical blade under anesthesia; the eyelids of the mice were sutured. Keratitis symptoms were grossly observed, and PCR was performed using P-FLA primers for amplification of the <em>Acanthamoeba</em> 18S-rRNA gene from the mouse ocular tissue. The experimental AK mouse model, characterized by typical hazy blurring and melting of the mouse cornea, was established on day 1 post-inoculation. AK was induced with at least 0.3×10<sup>5</sup> <em>A.</em> <em>castellanii</em> cells (optimal number, 5×10<sup>4</sup>), and the infection persisted for 2 months. In addition, PCR products amplified from the extracted mouse eye DNA confirmed the development of <em>Acanthamoeba</em>-induced keratitis during the infection periods. In conclusion, it is suggested that the present AK mouse model may serve as an important <em>in vivo</em> model for various future studies.</p>
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