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814
datasets available to search
ShareScore release 0.9.0
Dataset results
814 results for “LPS”
Lipopolysaccharide (LPS) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF) Challenge Study on Healthy Subjects
ClinicalTrials.gov study NCT03306589. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Lipopolysaccharide (LPS) Challenge in Depression
ClinicalTrials.gov study NCT03142919. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
A Study to Compare the NexGen LPS and LPS-Flex Knee Implants
ClinicalTrials.gov study NCT00763386. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Blood Lipopolysaccharide (LPS) Rifaximin Study
ClinicalTrials.gov study NCT02124512. IPD Sharing: NO. Countries: 1. Publications: 0.
Anti-LPS Antibody Treatment for Pediatric NAFLD
ClinicalTrials.gov study NCT03042767. IPD Sharing: NO. Countries: 1. Publications: 0.
Immunoadsorption of LPS, C5a and IL-6 in Severe Sepsis and Septic Shock (ISASS-1)
ClinicalTrials.gov study NCT00146432. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Body size and circulating levels of different molecules from tree swallows (Tachycineta bicolor) exposed to different doses of lipopolysaccharide (LPS)
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Data from: A synthetic cationic antimicrobial peptide inhibits inflammatory response and the NLRP3 inflammasome by neutralizing LPS and ATP
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Data from: Phylogenomic analysis supports the ancestral presence of LPS-outer membranes in the Firmicutes
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Data from: Biochemical and functional analysis of Cyanobacterium Oscillatoria sp. LPS on human monocytes
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Data from: Changes in the bacterial microbiota in gut, blood, and lungs following acute LPS instillation into mice lungs
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Data from: Microglia responses to pro-inflammatory stimuli (LPS, IFNγ+TNFα) and reprogramming by resolving cytokines (IL-4, IL-10)
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Immune responses to the in vitro LPS assault engineered in the spaceflight multi-omics study
Microgravity alters the immune response to in vitro LPS assault engineered in spaceflight: A multi-omics study Microgravity can facilitate creation of a potent environment for opportunistic infection by augmenting virulence and suppressing the host defense. Presumably extraterrestrial infection may trigger potentially novel bionetworks different from the terrestrial equivalent which could only be probed by investigating the host-pathogen relationship with minimum terrestrial bias. Towards this objective we strategically engineered a cell culture module equipped with a feedback controlled semi-automated platform to expose human endothelial cells to lipopolysaccharide (LPS). The assay was carried out in the STS-135 space shuttle and a concurrent ground study constituted the baseline. Transcriptomic investigation revealed an immune blunting in microgravity; Lbp MyD88 and MD-2 failed to encode proteins responsible for early LPS uptake. Longer exposure results implied that there was a delayed response potentially ineffectual in preventing pathogens from opportunistically modulating the infection network. Lack of recruitment of growth factors and a debilitated apoptosome supported this potential explanation. Certain cytokines such as IL-6 and IL-8 surged in response to LPS insult in microgravity. Contrasting expressions of B2M TIMP-1 and VEGRs suggested impaired pro-survival adaptation and healing mechanisms. The susceptibility of oxidative stress and immune regulation to microgravity compelled further investigation of the respective microRNA modulators such as miR-200a and miR-146b. These miRNAs were expressed differently in response to LPS assaults in different gravitational limits. In conclusion despite a serious drawback attributed to the small sample size we delineated some of the important aspects of the extraterrestrial etiology; more comprehensive follow up studies are warranted. Present study though compromised by the small sample size was able to shade lights on several aspects of immunological responses to the endotoxic assault mediated by uG. Implementing the host-pathogen interactions in the spaceflight and subsequently lysing the cells onboard presented the critical distinguishing features of the present study from the past reports. We identified the CCM of Tissue Genesis Inc. HI as the suitable hardware system to carry out the experiment in the spaceflight. CCM is an automated feedback controlled module that can concurrently support 24 bioreactors following protocols exclusively programmed for individual bioreactor. For this experiment we use samples EA41 EA 47 EA45 and EA155 that were exposed to LPS for 4 hours. Samples EA123 EA165 EA127 EA126 were exposed to LPS for 8Hrs. Samples EA33 EA 125 EA79 and EA 39 were controls in this experiment.
Gene expression changes in LPS-induced neuroinflammation
GEO Series GSE12284. Mus musculus. 16 samples. Type: Expression profiling by array.
CircRNA, lncRNA and mRNA expression profiles in normal and LPS-induced septic cardiomyopathy mice
GEO Series GSE142615. Mus musculus. 8 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Transcriptomic Changes in Microdissected CCDs after Three Hours Lipopolysaccharide (LPS) Administration in Rats
GEO Series GSE200928. Rattus norvegicus. 18 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic analysis of lung epithelial cells after LPS inhalation
GEO Series GSE176228. Mus musculus. 34 samples. Type: Expression profiling by high throughput sequencing.
TNF-signaling modulates neutrophil-mediated immunity at the feto-maternal interface during LPS-induced intrauterine inflammation
GEO Series GSE145918. Macaca mulatta. 23 samples. Type: Expression profiling by high throughput sequencing.
Real-time quantitative PCR analysis of mice lung tissue after inhalation of S100A8, S100A8 dimer, S100A9 or S100A8/A9 complex in acute lung [S100A8S100A9 LPS induced ALI]
GEO Series GSE74127. Mus musculus. 40 samples. Type: Expression profiling by RT-PCR.
Inhibition of γ-glutamyl transpeptidase suppresses LPS induced asthma exacerbation in a mouse model
GEO Series GSE217834. Mus musculus. 11 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.