Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
99
datasets available to search
ShareScore release 0.9.0
Dataset results
99 results for “WT1”
Effects continuous and transient lurbinectedin exposure on the EWS-WT1 gene signature in DSRCT
GEO Series GSE168441. Homo sapiens. 72 samples. Type: Expression profiling by high throughput sequencing.
Study on differentially expressed genes in the WT1 overexpressed group and the control group by RNA-seq
GEO Series GSE142985. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
mRNA sequencing analysis of transcripts from hippocampus of Wt1∆ mice
GEO Series GSE120708. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
CUT&RUN to map WT1 binding in M15 cell lines that are genome edited for the KTS isoforms.
GEO Series GSE189871. Mus musculus. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epigenetic transcriptional reprogramming by WT1 mediates a repair response during podocyte injury [RNA-seq]
GEO Series GSE154955. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [MAFb KO RNA-seq]
GEO Series GSE233912. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Wt1 regulates proliferation and differentiation of neural progenitors during brain development
GEO Series GSE131694. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters
GEO Series GSE233913. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Heterogeneity in human WT1-specific CD4+ T cell clone
GEO Series GSE137142. Homo sapiens. 3 samples. Type: Expression profiling by array.
MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [WT1-MAFB_ChIP-seq]
GEO Series GSE233910. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
CRISPR-based gene disruption coupled to targeted integration of novel, high-avidity, natural T cell receptors to WT1 for acute leukemia
GEO Series GSE166507. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
LKR13-Kras-WT1-KO
GEO Series GSE15326. Mus musculus. 10 samples. Type: Expression profiling by array.
Anti-leukemia activity of bortezomib through GATA2-WT1 axis in acute myeloid leukemia
GEO Series GSE188358. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
MEF-mKras-WT1
GEO Series GSE15325. Mus musculus. 23 samples. Type: Expression profiling by array.
MAFB permits differentiation by permitting WT1 binding to podocyte specific promoters [Histons modifications ChIP-seq]
GEO Series GSE233911. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Supplementary processed data for Chandler et al. Single-cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of a murine model of WT1 kidney disease
<p><strong><em>Summary datafiles for Chandler et al.</em></strong></p> <ul> <li>Processed single-cell RNA sequencing data, derived from murine glomeruli (isolated using the dynabead technique) from <em>n = 2</em> wild-type <em>Wt1<sup>+/+</sup></em> (Ctrl) and <em>n = 2</em> mutant <em>Wt1<sup>R394W/+</sup></em> (Mut) littermates of WT1 glomerulopathy, followed by 10x Genomics Chromium v3 platform.</li> <li>Please refer to associated scripts for analysis of the data: <a href="https://github.com/daniyal-jafree1995/collaborations/blob/main/Chandleretal_2022_WT1glomerulopathyscRNAseq.R">https://github.com/daniyal-jafree1995/collaborations/blob/main/Chandleretal_2022_WT1glomerulopathyscRNAseq.R</a> </li> <li>File descriptions as below: <ul> <li>barcodes.tsv.gz - barcodes file required for input to Read10X function in Seurat</li> <li>features.tsv.gz - features file required for input to Read10X function in Seurat</li> <li>matrix.mtx.gz - matrix file required for input to Read10X function in Seurat</li> <li>WT1_scRNAseq.rds - RDS file containing processed and annotated Seurat object for downstream analysis</li> </ul> </li> </ul>
FOXC2 and WT1 regulate transcriptional reprogramming during the podocyte response to injury
GEO Series GSE213174. Mus musculus. 6 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Whole-genome sequencing of chromatin in Hacat cells overexpressing WT1
GEO Series GSE142992. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
EWS-WT1 fusion isoforms establish oncogenic programs and therapeutic vulnerabilities in Desmoplastic Small Round Cell Tumors
<p>EWS fusion oncoproteins underlie the pathogenesis of several human malignancies including Desmoplastic Small Round Cell Tumor (DSRCT), an aggressive mesenchymal tumor driven by fusions between the disordered domain of EWS and the developmental transcription factor WT1. Here we combined chromatin occupancy and long-range interaction profiles to identify EWS-WT1-dependent gene regulation networks and directly controlled target genes. We show that EWS-WT1 operates primarily as a powerful activator of distal regulatory elements and controls an oncogenic gene expression program that characterize primary DSRCTs. Moreover, EWS-WT1 has two isoforms that differ by three amino acids in their DNA binding domain (+/- KTS), as observed for wild type WT1, and we show that each fusion isoform has a specific DNA binding profile that is distinct from its wild type counterparts and requires a functional EWSR1 prion like domain. Remarkably, xenograft experiments using human mesothelial cells, candidate cells of origin of DSRCT, reveal that both isoforms are required to generate viable tumors that resemble DSRCT. Finally, we identify new candidate EWS-WT1 target genes with potential therapeutic implications, including <em>CCND1</em>, whose inhibition by the clinically-approved drug Palbociclib leads to marked tumor burden decrease in DSRCT PDXs <em>in vivo</em>. Taken together, our studies identify gene regulation programs and therapeutic vulnerabilities in DSRCT and provide a mechanistic understanding of the complex isoform-dependent oncogenic activity of EWS-WT1.</p>
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.