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197 results for “beat”
BEAT-Breast: Trial of DE-iPTV in Patients With Primary Breast Cancer With Brain Metastases Who Are Not Suitable for Stereotactic Radiotherapy.
ClinicalTrials.gov study NCT06611306. IPD Sharing: NO. Countries: 1. Publications: 1.
Effect of Binaural Beats for Maintenance of General Anesthesia
ClinicalTrials.gov study NCT06002568. IPD Sharing: Not stated. Countries: 1. Publications: 14.
Data for spin quantum beats in pump push spectroscopy
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Data from: Effects of the selective stretch-activated channel blocker GsMtx4 on stretch-induced changes in refractoriness in isolated rat hearts and on ventricular premature beats and arrhythmias after coronary occlusion in swine
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Going with the flow: corals in high-flow environments can beat the heat
<p>Coral reefs are experiencing unprecedented declines in health on a global scale leading to severe reductions in coral cover. One major cause of this decline is increasing sea surface temperature. However, conspecific colonies separated by even small spatial distances appear to show varying responses to this global stressor. One factor contributing to differential responses to heat stress is variability in the coral's micro-environment, such as the amount of water flow a coral experiences. High flow provides corals with a variety of health benefits, including heat stress mitigation. Here, we investigate how water flow affects coral gene expression and provides resilience to increasing temperatures. We examined host and photosymbiont gene expression of <i>Acropora </i>cf. <i>pulchra </i>colonies in discrete <i>in situ</i> flow environments during a natural bleaching event. In addition, we conducted controlled <i>ex situ </i>tank experiments where we exposed <i>A. </i>cf.<i> pulchra </i>to different flow regimes and acute heat stress. Notably, we observed distinct flow-driven transcriptomic signatures related to energy expenditure, growth, heterotrophy and a healthy coral host-photosymbiont relationship. We also observed disparate transcriptomic responses during bleaching recovery between the high- and low-flow sites. Additionally, corals exposed to high flow showed "frontloading" of specific heat-stress related genes such as heat shock proteins, antioxidant enzymes, genes involved in apoptosis regulation, innate immunity, and cell adhesion. We posit that frontloading is a result of increased oxidative metabolism generated by the increased water movement. Gene frontloading may at least partially explain the observation that colonies in high-flow environments show higher survival and/or faster recovery in response to bleaching events.</p>
Supplementary material 1 from: Cassetta L, Rodrigues PM, Andreu T, Botta B, Brandau S, Brierley C, Wilson C, Dadeshidze I, Forzi L, Ortelli F, Quintas MA.C (2020) Beating Cancer by 2030: Mission Impossible? Research Ideas and Outcomes 6: e61662. https://doi.org/10.3897/rio.6.e61662
Booklet of the Workshop - Beating cancer by 2030: mission impossible?
Figure 2 from: Cassetta L, Rodrigues PM, Andreu T, Botta B, Brandau S, Brierley C, Wilson C, Dadeshidze I, Forzi L, Ortelli F, Quintas MA.C (2020) Beating Cancer by 2030: Mission Impossible? Research Ideas and Outcomes 6: e61662. https://doi.org/10.3897/rio.6.e61662
Figure 2 COST Actions representatives and Stakeholders short presentations on their activities in Beating Cancer.
Figure 1 from: Cassetta L, Rodrigues PM, Andreu T, Botta B, Brandau S, Brierley C, Wilson C, Dadeshidze I, Forzi L, Ortelli F, Quintas MA.C (2020) Beating Cancer by 2030: Mission Impossible? Research Ideas and Outcomes 6: e61662. https://doi.org/10.3897/rio.6.e61662
Figure 1 Dr Wolfgang Burtscher, Deputy Director General at DG Research and Innovation (EC) (L) opened the event presenting an overview of the state of play of current Horizon Europe negotiations and the planned Mission in the field of Cancer. Dr Sanja Damjanovic, Minister for Science in Montenegro (R), presented the roadmap for establishing The South East European International Institute for Sustainable Technologies (SEEIIST), which aims developing Hadron Cancer Therapy and Biomedical Research with Protons and Heavy Ions.
Data from: The molecular trigger for high-speed wing beats in a bee
The high-frequency wing beat of higher-order insects is driven by self-sustained oscillations of constantly activated flight muscles. However, it remains unknown whether its underlying mechanism is based on flight muscle–specific features or on preexisting contractile functions. Here, we recorded x-ray diffraction movies, at a rate of 5000 frames per second, simultaneously from the two antagonistic flight muscles of bumblebees during wing beat. Signals that occurred at the right timing for triggering each wing-beat stroke were resolved in both muscles. The signals likely reflect stretch-induced myosin deformation, which would also enhance force in vertebrate muscles. The results suggest that insects use a refined preexisting force-enhancing mechanism for high-frequency wing beat, rather than developing a novel mechanism.
Data from: Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella
Cilia and flagella are model systems for studying how mechanical forces control morphology. The periodic bending motion of cilia and flagella is thought to arise from mechanical feedback: dynein motors generate sliding forces that bend the flagellum, and bending leads to deformations and stresses, which feed back and regulate the motors. Three alternative feedback mechanisms have been proposed: regulation by the sliding forces, regulation by the curvature of the flagellum, and regulation by the normal forces that deform the cross-section of the flagellum. In this work, we combined theoretical and experimental approaches to show that the curvature control mechanism is the one that accords best with the bending waveforms of Chlamydomonas flagella. We make the surprising prediction that the motors respond to the time derivative of curvature, rather than curvature itself, hinting at an adaptation mechanism controlling the flagellar beat.
Data from: Midbrain adaptation may set the stage for the perception of musical beat
The ability to spontaneously feel a beat in music is a phenomenon widely believed to be unique to humans. Though beat perception involves the coordinated engagement of sensory, motor, and cognitive processes in humans, the contribution of low-level auditory processing to the activation of these networks in a beat-specific manner is poorly understood. Here, we present evidence from a rodent model that midbrain pre-processing of sounds may already be shaping where the beat is ultimately felt. For the tested set of musical rhythms, on-beat sounds on average evoked higher firing rates than off-beat sounds, and this difference was a defining feature of the set of beat interpretations most commonly perceived by human listeners over others. Basic firing rate adaptation provided a sufficient explanation for these results. Our findings suggest that midbrain adaptation, by encoding the temporal context of sounds, creates points of neural emphasis that may influence the perceptual emergence of a beat.
PAAQ-Heart : Beating Embryonic Zebrafish Heart Imaged by Paired Alternating Acquisitions (PAAQ) Microscopy
<p><strong>Description</strong></p><p>This dataset contains images of the beating heart of live embryonic zebrafish acquired using Paired Alternating AcQuisitions (PAAQ) microscopy.</p><p>The dataset was collected to illustrate a multichannel video reconstruction method, which virtually increases the framerate of a repeating process (e.g., cardiac heartbeat) as compared to what would be achievable through direct imaging with a single-channel fluorescence setup and a low-framerate camera.</p><p>The imaged embryos were obtained by crossing transgenic Tg(<i>fli1a:GFP</i>)<i>y1Tg</i> and Tg(<i>myl7:mRFP</i>)<i>ko08Tg</i> zebrafish and selecting homozygous embryos. The embryos were were imaged at 4dpf on an implementation of the OpenSPIM microscope equiped with and the illumination controller available as part of the CBI-MMTools microscopy controltools package for micromanager (https://github.com/idiap/CBI-MMTools) to generate alternating illumination patterns in even and odd frames. The odd frames correspond to illumination by a brightfield with intensity that increases as a ramp over the duration of the frame exposure (reference modality) and even frames are either the result of laser illumination (fluorescence imaging) or a short brightfield illumination burst.</p><p> </p><p><strong>Reference</strong></p><p>If you use this dataset, please cite the following publication:</p><p><i>Marelli, F., Ernst, A., Mercader, N., Liebling, M. (2023). PAAQ: Paired Alternating AcQuisitions for Virtual High Frame Rate Multichannel Cardiac Fluorescence Microscopy. Biological Imaging, 3, E20.</i><br><a href="https://doi.org/10.1017/S2633903X23000223 ">10.1017/S2633903X23000223</a></p>
Ciliary beating patterns map onto a low-dimensional behavioural space
<p>Biological systems are robust to perturbations at both the genetic and environmental levels, although these same perturbations can elicit variation in behaviour. The interplay between functional robustness and behavioural variability is exemplified at the organellar level by the beating of cilia and flagella. Cilia are motile despite wide genetic diversity between and within species, differences in intracellular concentrations of ATP and calcium, and considerable environment fluctuations in temperature and viscosity. At the same time, these perturbations result in a variety of spatio-temporal patterns that span a rich behavioural space. To investigate this behavioural space we analysed the dynamics of isolated cilia from the unicellular algae Chlamydomonas reinhardtii under many different environmental and genetic conditions. We found that, despite large changes in beat frequency and amplitude, the space of waveform shapes is low-dimensional in the sense that two features account for 80% of the observed variation. The geometry of this behavioural space accords with the predictions of a simple mechanochemical model in the low-viscosity regime. This allowed us to associate waveform shape variability with changes in only the curvature response coefficients of the dynein motors.</p>
Black Education and Treatment of Hypertension (BEAT HTN)
ClinicalTrials.gov study NCT00661895. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Beraprost-314d Added-on to Tyvaso® (BEAT)
ClinicalTrials.gov study NCT01908699. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Comparison of Effects of Mirror Therapy Combined With Neuromuscular Electrical Stimulation or Binaural Beats Stimulation on Cortical Excitability, Heart Rate Variability and Lower Limb Motor Function
ClinicalTrials.gov study NCT06011018. IPD Sharing: NO. Countries: 1. Publications: 0.
Beat to Beat A Study in Paediatric, Adolescent and Young Adult Patients Who Are Undergoing or Have Undergone Cancer Therapy to Evaluate the Agreement Between QTc Measured Using 12 Lead Electrocardiogr
ClinicalTrials.gov study NCT05615376. IPD Sharing: YES. Countries: 1. Publications: 0.
Beating the Blues for Your Heart
ClinicalTrials.gov study NCT01605552. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Binaural Beats Stimulation on the Autonomic Nervous System (ANS), Kinesiophobia and Fitness Levels in Professional Athletes With Musculoskeletal (MSK) Injuries
ClinicalTrials.gov study NCT07370636. IPD Sharing: Not stated. Countries: 0. Publications: 9.
Data from: Dynamic curvature regulation accounts for the symmetric and asymmetric beats of Chlamydomonas flagella
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.