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1,264 results for “clinical assessment”
Clinical trial generalizability assessment in the big data era: a review
Open the record for dataset details and reuse information.
Assessment of clinical outcomes with immune checkpoint inhibitor therapy in melanoma patients with CDKN2A and TP53 pathogenic mutations
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Novel health system strategies for tuberculin skin testing at primary care clinics: performance assessment and health economic evaluation.
<p>Datasets for journal paper.</p>
Data from: Non-clinical safety assessment of CFZ533, a Fc-silent anti-CD40 antibody, in Cynomolgus monkeys
CFZ533 is a pathway blocking, non-depleting anti-CD40 antibody that is in clinical development for inhibition of transplant organ rejection and therapy for autoimmune diseases. A 26-week GLP toxicity study in sexually mature Cynomolgus monkeys was conducted in order to support chronic application of CFZ533. CFZ533 was subcutaneously administered at doses up to 150 mg/kg/week and was safe and generally well tolerated. CFZ533 showed no adverse effects for cardiovascular, respiratory and neurobehavioral endpoints, and no changes were observed for blood lymphocyte and platelet counts or blood coagulation markers. In line with the non-depleting nature of CFZ533, CD20+ B cells in the blood were only marginally reduced. A complete suppression of germinal center (GC) development in lymph nodes and spleen was the most prominent result of post-mortem histological investigations. This was corroborated by an abrogated T-dependent antibody response (TDAR) to the antigen Keyhole Limpet Hemocyanin (KLH) as well as an absence of anti-drug antibodies (ADAs) in the absence of B cell depletion as seen with immunophenotyping and histology. When serum levels of CFZ533 in recovery animals dropped levels necessary for full CD40 occupancy on B cells, all animals were able to mount a TDAR to KLH. All histological changes also reverted to normal appearance after recovery. In summary, CFZ533 was shown to be well tolerated and safe in the 26-week toxicity study with a distinct pharmacodynamic profile in histology and immune function.
Contrast MR Based Radiomics and Machine Learning Analysis to assess clinical outcomes following liver resec-tion in Colorectal Liver Metastases: a preliminary study
<p>We uploaded the images of the manuscript "Contrast MR Based Radiomics and Machine Learning Analysis to assess clinical outcomes following liver resection in Colorectal Liver Metastases: a preliminary study" accepted on Cancers.</p> <p>Vincenza Granata1*, Roberta Fusco2, Federica De Muzio3, Carmen Cutolo4, Sergio Venanzio Setola1, Federica dell’ Aversana5, Alessandro Ottaiano6, Antonio Avallone6, Guglielmo Nasti6, Francesca Grassi5, Vincenzo Pilone4, Vittorio Miele7-8, Luca Brunese3, Francesco Izzo9, Antonella Petrillo1</p> <p>1Division of Radiology, “Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli”, Naples, Italy</p> <p>2Medical Oncology Division, Igea SpA, Napoli, Italy</p> <p>3Department of Medicine and Health Sciences “V. Tiberio”, University of Molise, 86100 Campobasso, Italy</p> <p>4Department of Medicine, Surgery and Dentistry, University of Salerno, Salerno, Italy</p> <p>5Division of Radiology, “Università degli Studi della Campania Luigi Vanvitelli”, Naples, Italy</p> <p>.6Division of Abdominal Oncology, “Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli”, Naples, Italy</p> <p>7Division of Radiology, “Azienda Ospedaliera Universitaria Careggi”, Florence, Italy</p> <p>8Italian Society of Medical and Interventional Radiology (SIRM), SIRM Foundation, via della Signora 2, 20122 Milan, Italy</p> <p>9Division of Epatobiliary Surgical Oncology,“Istituto Nazionale Tumori IRCCS Fondazione Pascale – IRCCS di Napoli”, Naples, Italy</p> <p> </p>
EOB-MR Based Radiomics Analysis to Assess Clinical Outcomes Following Liver Resection in Colorectal Liver Metastases
<p>I uploaded the images of the manuscript " EOB-MR Based Radiomics Analysis to Assess Clinical Outcomes Following Liver Resection in Colorectal Liver Metastases" accepted on Cancers Journal.</p>
Radiomics Textural Features by MR Imaging to assess clinical outcomes following liver resection in Colorectal Liver Metastases
<p>I uploaded the images od the manuscript "Radiomics Textural Features by MR Imaging to assess clinical outcomes following liver resection in Colorectal Liver Metastases"</p>
A comparative immunological assessment of multiple clinical-stage adjuvants for the R21 malaria vaccine in nonhuman primates
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Systematic assessment of tumour purity and its clinical implications
<p>Supplemental data for the study: Systematic assessment of tumour purity and its clinical implications</p>
Assessment of four in vitro phenotypic biofilm detection methods in relation to antimicrobial resistance in aerobic clinical bacterial isolates
<p><strong>Introduction</strong>: The lack of standardized methods for detecting biofilms continues to pose a challenge to microbiological diagnostics since biofilm-mediated infections induce persistent and recurrent infections in humans that often defy treatment with common antibiotics. This study aimed to evaluate diagnostic parameters of four in vitro phenotypic biofilm detection assays in relation to antimicrobial resistance in aerobic clinical bacterial isolates.</p> <p><strong>Methods</strong>: In this cross-sectional study, bacterial strains from clinical samples were isolated and identified following the standard microbiological guidelines. The antibiotic resistance profile was assessed through the Kirby-Bauer disc diffusion method. Biofilm formation was detected by gold standard tissue culture plate method (TCPM), tube method (TM), Congo red agar (CRA), and modified Congo red agar (MCRA). Statistical analyses were performed using SPSS version 17.0, with a significant association considered at p<0.05.</p> <p><strong>Result</strong>: Among the total isolates (n=226), TCPM detected 140 (61.95%) biofilm producers, with CoNS (9/9) (p<0.001) as the predominant biofilm former. When compared to TCPM, TM (n=119) (p<0.001) showed 90.8% sensitivity and 70.1% specificity, CRA (n=88) (p=0.123) showed 68.2% sensitivity and 42% specificity, and MCRA (n=86) (p=0.442) showed 65.1% sensitivity and 40% specificity. Juxtaposed to CRA, colonies formed on MCRA developed more intense black pigmentation from 24 to 96 hours. There were 77 multi-drug-resistant (MDR)-biofilm formers and 39 extensively drug-resistant (XDR)-biofilm formers, with 100% resistance to ampicillin and ceftazidime, respectively.</p> <p><strong>Conclusion</strong>: It is suggested that TM be used for biofilm detection. Unlike MCRA, black pigmentation in colonies formed on CRA declined with time. MDR- and XDR-biofilm formers were frequent among the clinical isolates.</p>
CONSORT Checklist for The assessment of educational and supportive care to the infertile females undergoes In Vitro Fertilization procedure by clinical pharmacist: A Randomized Clinical Trial
<p>CONSORT Checklist for The assessment of educational and supportive care to the infertile females undergoes In Vitro Fertilization procedure by clinical pharmacist: A Randomized Clinical Trial</p>
The assessment of educational and supportive care to the infertile females undergoes In Vitro Fertilization procedure by clinical pharmacist: A Randomized Clinical Trial
<p>The assessment of educational and supportive care to the infertile females undergoes In Vitro Fertilization procedure by clinical pharmacist: A Randomized Clinical Trial</p>
Clinical Study to Assess the Mode of Action of QBW251 in Patients With Chronic Obstructive Pulmonary Disease (COPD)
ClinicalTrials.gov study NCT04268823. IPD Sharing: YES. Countries: 4. Publications: 0.
A Proof-of-concept Clinical Trial Assessing the Safety of the Coordinated Undermining of Survival Paths by 9 Repurposed Drugs Combined With Metronomic Temozolomide (CUSP9v3 Treatment Protocol) for Rec
ClinicalTrials.gov study NCT02770378. IPD Sharing: NO. Countries: 1. Publications: 2.
Phase Ib/II Study Assessing the Clinical Activity and Safety of Brexucabtagene Autoleucel as a Consolidation in Patients With Relapsed/Refractory (R/R) and Newly Diagnosed B-cell Acute Lymphocytic Leu
ClinicalTrials.gov study NCT06287229. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Registry Assessment of the Missouri Osteochondral Allograft Preservation System - MOPS
ClinicalTrials.gov study NCT02503228. IPD Sharing: Not stated. Countries: 1. Publications: 21.
A Phase II Clinical Study to Assess the Efficacy and Safety of IBI310 or Placebo Combined With Sintilimab for Advanced Cervical Cancer Subjects Who Have Failed or Cannot Tolerate First-line or Above P
ClinicalTrials.gov study NCT04590599. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessing the Suitability of an Imaging Probe for Use in Clinical Cell and Gene Therapy Trials in Cancer and Rheumatoid Arthritis
ClinicalTrials.gov study NCT00185848. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Assessing Impact of CCO's PSO & PC Pathway in Ambulatory HNC Clinics
ClinicalTrials.gov study NCT03266276. IPD Sharing: NO. Countries: 1. Publications: 43.
A Randomized Clinical Trial Assessing Smoking Cessation Interventions In Dental Clinic Smokers
ClinicalTrials.gov study NCT00591175. IPD Sharing: Not stated. Countries: 1. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.