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6,512 results for “clinical trial”
Ivermectin as an adjuvant to anti-epileptic treatment in persons with onchocerciasis-associated epilepsy: a randomized proof-of-concept clinical trial
<p>Open dataset for a proof-of-concept randomized clinical trial with a four month follow-up period was conducted to investigate whether ivermectin had an added value in decreasing the frequency of seizures in onchocerciasis-infected persons with epilepsy (PWE). The 90 PWE with epilepsy were randomly allocated to the treatment arms: phenobarbital + ivermectin (n = 44) or phenobarbital alone (n = 46). Two weeks after randomization, a follow-up visit was scheduled to assess the early treatment outcomes and potential side effects of AED. After the second week visit, PWE had to report to the health center for further follow-up consultations by the project nurses and medical doctors, scheduled at 1, 2, 3 and 4 months. By March 2018, 89 (99%) participants in both arms attended the final follow-up visit. The trial was conducted in five onchocerciasis-endemic villages within the Logo health zone in the Ituri province, DRC: Draju, Kanga, Wala, Ulyeko and Thedeja. </p> <p>At baseline, information was collected on seizure semiology, seizure frequency, epilepsy risk factors, relevant medical history, previous AED and ivermectin use. Weight and height measurements were carried out on all participants, followed by a complete physical and neurological examination performed by one of the medical doctors who had been trained in epilepsy, or by the neurologist. Cognitive impairment was assessed by determining whether the participant was well oriented in time and place, whether he/she could remember his/her name, was coherent in speech, and was obedient to orders; abnormal behaviour such as unexplained aggressive attitudes and/or wandering episodes were also noted.</p> <p> </p> <p> </p>
Evaluating the Impact of Triple Compound Therapy on Relapse Frequency and Quality of Life in Children with Severe Atopic Dermatitis: A Phase II Randomised Clinical Trial
<p>Datasets and analysis from A multi-centre, randomized controlled trial, on pediatric Atopic Dermatitis, conducted at Red Cross and Walter Sisulu Hospitals. The study is entitled Evaluating the Impact of Triple Compound Therapy on Relapse Frequency and Quality of Life in Children with Severe Atopic Dermatitis: A Phase II Randomised Clinical Trial.</p>
The influence of the statistical significance of results and spin on readers' interpretation of the results in an abstract for a hypothetical clinical trial: A randomized trial
<p><strong>Objectives</strong>: To assess the impact on readers' interpretation of the results reported in an abstract for a hypothetical clinical trial with 1) a statistically significant result, 2) spin, 3) both a statistically significant result and spin compared to 4) no spin and no statistically significant result.</p> <p><strong>Participants</strong>: Health students and professionals from universities and health institutions in France and the UK.</p> <p><strong>Interventions</strong>: Participants completed an online questionnaire using Likert scales and free text, after reading one of the four versions of an abstract about a hypothetical randomized trial evaluating "Naranex" and "Bulofil" (two hypothetical drugs) for chronic low back pain. The abstracts differed in a) reported result of "mean difference of 1.31 points (95%CI 0.08 to 2.54; p= 0.04)" or "mean difference of 1.31 points (95%CI -0.08 to 2.70; p= 0.06)" and b) presence or absence of spin. The effect size for the trial's primary outcome (pain disability score) was the same in each abstract; slightly in favour of Naranex.</p> <p><strong>Primary outcome</strong>: The reader's interpretation of the trial's results, based on their answer (1: disagree, 4: neutral, 7: agree) to the following statement: "About the main findings of the study, what is your opinion about the following statement: 'Naranex is better than Bulofil'?"</p> <p><strong>Results</strong>: 297 of the 404 people randomized to receive one of the four abstracts completed the study. Respondents were more likely to favour Narenex when the abstract reported a statistically significant result without spin; a statistically significant result with spin, a non-statistically significant result with spin, compared to when it reported a non-statistically significant result without spin.</p> <p><strong>Conclusions</strong>: Statistical significance appears to have influenced readers' perception whatever the level of spin, while spin influenced readers' perception when the results were not statistically significant but did not appear to have an impact when results were statistically significant</p>
Call to Action: Overcoming Enrollment Disparities in Cancer Clinical Trials with Modernized Eligibility Criteria
<p>Dataset used for paper: "Call to Action: Overcoming Enrollment Disparities in Cancer Clinical Trials with Modernized Eligibility Criteria." Data extracted from clinicaltrials.gov.</p>
How Safe and Technical Is Modified Dunn Osteotomy in the Management of Patients with SCFE: A Clinical Trial with Short Term Followup
<p>This is the master datasheet used to support the findings of this study and Video 1 containing intraoperative scenes to show bleeding femoral head</p>
The PLATINUM Clinical Trial to Assess the PROMUS Element Stent System for Treatment of Long De Novo Coronary Artery Lesions (PLATINUM LL)
ClinicalTrials.gov study NCT01500434. IPD Sharing: UNDECIDED. Countries: 7. Publications: 2.
Phase 3 Clinical Trial with Dapagliflozin in Chronic Kidney Disease in Adolescents and Young Adult Patients
ClinicalTrials.gov study NCT05944016. IPD Sharing: YES. Countries: 1. Publications: 2.
Clinical Trial to Assess the Efficacy and Safety of Ciclesonide Hydrofluoroalkane (HFA) Nasal Aerosol for the Treatment of Seasonal Allergic Rhinitis
ClinicalTrials.gov study NCT00790023. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Confirmatory Clinical Trial of the Evera MRI System for Conditionally-safe MRI Access
ClinicalTrials.gov study NCT02117414. IPD Sharing: Not stated. Countries: 13. Publications: 2.
Evaluation of Bioflex and Zirconia Crowns Versus Stainless Steel Crowns on Primary Molars: Randomized Controlled Clinical Trial
ClinicalTrials.gov study NCT07156838. IPD Sharing: NO. Countries: 1. Publications: 3.
Enhanced, EHR-facilitated Cancer Symptom Control Pragmatic Clinical Trial
ClinicalTrials.gov study NCT03892967. IPD Sharing: Not stated. Countries: 1. Publications: 7.
A Clinical Trial of CSL's 2009 H1N1 Influenza Vaccine (CSL425) in Healthy Children
ClinicalTrials.gov study NCT00940108. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Trial of Apomorphine Subcutaneous Infusion in Patients With Advanced Parkinson's Disease
ClinicalTrials.gov study NCT02006121. IPD Sharing: NO. Countries: 7. Publications: 2.
Choroideremia Gene Therapy Clinical Trial
ClinicalTrials.gov study NCT02553135. IPD Sharing: Not stated. Countries: 1. Publications: 1.
B Vitamin Supplementation to Chiropractic Management of Chronic LBP: Pilot Clinical Trial (VCLBP)
ClinicalTrials.gov study NCT06576739. IPD Sharing: YES. Countries: 1. Publications: 10.
Prospective Trial to Compare the Clinical Efficiency of G-EYE™ HD Colonoscopy With Standard HD Colonoscopy
ClinicalTrials.gov study NCT01917513. IPD Sharing: Not stated. Countries: 8. Publications: 1.
A Clinical Trial of Ambrisentan and Tadalafil in Pulmonary Arterial Hypertension Associated With Systemic Sclerosis
ClinicalTrials.gov study NCT01042158. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Clinical Trial of Safety and Efficacy of Afalaza in Patients With Symptoms of Benign Prostatic Hyperplasia and Risk of Progression
ClinicalTrials.gov study NCT01716104. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Phase I Clinical Trial of a COVID-19 Vaccine in 18-60 Healthy Adults
ClinicalTrials.gov study NCT04313127. IPD Sharing: YES. Countries: 1. Publications: 1.
Enhanced Dynamic Clinical Decision Support System Pragmatic Trial (E-DYNAMIC)
ClinicalTrials.gov study NCT03826758. IPD Sharing: YES. Countries: 1. Publications: 8.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.