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Dataset results
314 results for “curcumin”
Study of Liposomal Curcumin in Combination With RT and TMZ in Patients With Newly Diagnosed High-Grade Gliomas
ClinicalTrials.gov study NCT05768919. IPD Sharing: NO. Countries: 1. Publications: 1.
Nutritional Supplementation of Flavonoids Quercetin and Curcumin for Early Mild Symptoms of COVID-19
ClinicalTrials.gov study NCT05130671. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Curcumin for Type 2 Diabetic Patients
ClinicalTrials.gov study NCT01052597. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Nano-curcumin Supplementation in Acute Pancreatitis
ClinicalTrials.gov study NCT04989166. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Curcumin on Iron Metabolism in Healthy Volunteer
ClinicalTrials.gov study NCT01489592. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Study Investigating the Ability of Plant Exosomes to Deliver Curcumin to Normal and Colon Cancer Tissue
ClinicalTrials.gov study NCT01294072. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Exploratory Non Comparative Study to Evaluate the Efficacy of Highly Bioavailable Curcumin (Flexofytol) in Patients With Knee Osteoarthritis
ClinicalTrials.gov study NCT01909037. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Oral Curcumin for the Treatment of Pain of Thumb Base Joint (CMC) Arthritis
ClinicalTrials.gov study NCT06359665. IPD Sharing: NO. Countries: 1. Publications: 13.
The Effects of an Anti-inflammatory Diet With or Without Curcumin Supplementation on Anthropometric Measurements, Concentrations of Thyroid Hormones, Anti-TPO, and Systemic Inflammation in Plasma and
ClinicalTrials.gov study NCT05975866. IPD Sharing: NO. Countries: 1. Publications: 1.
The Impact of Addition of Curcumin for 10 Days Triple Therapy, on the Eradication Rate of Helicobacter Pylori Infection
ClinicalTrials.gov study NCT02018328. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Data from: Curcumin improves glycolipid metabolism through regulating peroxisome proliferator activated receptor γ signalling pathway in high-fat diet-induced obese mice and 3T3-L1 adipocytes
Curcumin, an active component derived from the Curcuma longa L. which is a traditional Chinese medicine that is widely used for treating metabolic diseases through regulating different molecular pathway. Here, in this study, we aimed to comprehensively investigate the effects of curcumin on glycolipid metabolism in vivo and in vitro and then determine the underlying mechanism. Male C57BL/6J obese mice and 3T3-L1 adipocytes were used in vivo and in vitro study, respectively. Our results demonstrated that treatment with curcumin for 8 weeks decreased body weight, fat mass and serum lipid profiles. Meanwhile, it lowered fasting blood glucose and increased the insulin sensitivity in high-fat diet induced obese mice. In addition, curcumin stimulated lipolysis and improve glycolipid through upregulating the expressions of ATGL, HSL, PPARγ, C/EBPα and PPARα in adipose tissue of the mice. In differentiated 3T3-L1 cells, curcumin reduced glycerol release and increased glucose uptake via upregulating PPARγ and C/EBPα. We concluded that curcumin has potential to improve glycolipid metabolism disorders caused by obesity through regulating PPARγ signaling pathway.
Figure 6 from: Shannag S, Nuseir K, Tahaineh L, Hananeh W (2024) Curcumin is comparable to metformin for the treatment of PCOS in rats: a preclinical study. Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119708
Figure 6 Ovarian section from G6 group showing disrupted follicular development, lack of corpora lutea and presence of follicular cysts.
Figure 3 from: Shannag S, Nuseir K, Tahaineh L, Hananeh W (2024) Curcumin is comparable to metformin for the treatment of PCOS in rats: a preclinical study. Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119708
Figure 3 Hormonal and metabolic serum levels over time. Changes in serum levels of testosterone, estradiol, progesterone, and glucose before and after treatment with metformin, curcumin, metformin + curcumin, and olive oil compared to control rats' side by side. Data expressed as mean ± SEM (n = 16–17).
Figure 5 from: Shannag S, Nuseir K, Tahaineh L, Hananeh W (2024) Curcumin is comparable to metformin for the treatment of PCOS in rats: a preclinical study. Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119708
Figure 5 Ovarian section from G3 group showing multiple variably sized follicular cysts with disrupted normal follicular development.
Figure 2 from: Shannag S, Nuseir K, Tahaineh L, Hananeh W (2024) Curcumin is comparable to metformin for the treatment of PCOS in rats: a preclinical study. Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119708
Figure 2 Hormonal and metabolic serum levels. Changes in serum levels of testosterone, estradiol, progesterone, and glucose before and after treatment with metformin, curcumin, metformin + curcumin, and olive oil compared to control rats. Data expressed as mean ± SEM (n = 16–17). *Significantly different form control. A. Testosterone levels in ng/ml following letrozole injections and before treatment at age 9 weeks; B. Estradiol levels in pg/ml following letrozole injections and before treatment at age 9 weeks; C. Progesterone levels in ng/ml following letrozole injections and before treatment at age 9 weeks; D. Glucose serum levels mg/dl following letrozole injections and before treatment at age 9 weeks; E. Testosterone levels in ng/ml following treatment at age 12 weeks; F. Estradiol levels in pg/ml following treatment at age 12 weeks; G. Progesterone levels in ng/ml following treatment at age 12 weeks; H. Glucose serum levels mg/dl following treatment at age 12 weeks.
Figure 4 from: Shannag S, Nuseir K, Tahaineh L, Hananeh W (2024) Curcumin is comparable to metformin for the treatment of PCOS in rats: a preclinical study. Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119708
Figure 4 Ovarian section from control group showing different stages of follicular development and normal ovarian morphology.
Figure 1 from: Shannag S, Nuseir K, Tahaineh L, Hananeh W (2024) Curcumin is comparable to metformin for the treatment of PCOS in rats: a preclinical study. Pharmacia 71: 1-10. https://doi.org/10.3897/pharmacia.71.e119708
Figure 1 Changes in body weight before (DI, week 6) PCOS induction, after PCOS induction (T, week 9), and following treatments (sac, week 12) with metformin, curcumin, combination of met +cur and olive oil. Data expressed as mean ± SEM (n = 16–17). ** significant difference from control group.
High-protein Oral Supplement With Liposomal Curcumin in Adults Undergoing Hemodialysis.
ClinicalTrials.gov study NCT06381076. IPD Sharing: NO. Countries: 1. Publications: 0.
Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation.
ClinicalTrials.gov study NCT06581094. IPD Sharing: NO. Countries: 1. Publications: 0.
Comparison of Duration of Treatment Interruption With or Without Curcumin During the Off Treatment Periods in Patients With Prostate Cancer Undergoing Intermittent Androgen Deprivation Therapy
ClinicalTrials.gov study NCT03211104. IPD Sharing: Not stated. Countries: 0. Publications: 2.
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