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95
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ShareScore release 0.9.0
Dataset results
95 results for “diffuse intrinsic pontine glioma”
Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG)
ClinicalTrials.gov study NCT07206849. IPD Sharing: NO. Countries: 0. Publications: 0.
Targeting SWI/SNF ATPases in H3.3K27M Diffuse Intrinsic Pontine Gliomas
GEO Series GSE229454. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Genome-wide localization of RNA polymerase II and histone modifications in diffuse intrinsic pontine glioma cells in response to CDK9 inhibition
GEO Series GSE129777. Homo sapiens. 10 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Oncohistone H3.3K27M-driven CREB5/ID1 Axis Mediates the Malignant Cell States of Diffuse Intrinsic Pontine Glioma (DIPG) [HiC]
GEO Series GSE277795. Mus musculus. 8 samples. Type: Other.
Affymetrix SNP array data for Diffuse Intrinsic Pontine Glioma
GEO Series GSE18828. Homo sapiens. 18 samples. Type: Genome variation profiling by SNP array; SNP genotyping by SNP array.
Potent anti-tumor efficacy of palbociclib in H3K27M-mutant diffuse intrinsic pontine glioma
GEO Series GSE115976. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
RNA-Seq of VUMC-DIPG10 and HSJD-DIPG007 human diffuse intrinsic pontine glioma cells treated with a copper chelator
GEO Series GSE215220. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Utilizing Omomyc to Target MYCN-Amplified Diffuse Intrinsic Pontine Gliomas
GEO Series GSE201936. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
TP53 wild type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist
GEO Series GSE189152. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
OLIG2 maintenance is not essentially required for diffuse intrinsic pontine glioma cell line growth but regulates tumor phenotypes
GEO Series GSE157158. Homo sapiens. 19 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing.
Next generation sequencing of diffuse intrinsic pontine glioma samples to identify recurrent mutations, variations, and expression patterns to define novel therapies
Diffuse intrinsic pontine glioma (DIPG) is an extremely rare (~350 cases/year) and universally fatal childhood brain cancer. Standard clinical strategies such as chemotherapy and radiotherapy show only transient improvement in patient condition and result in negligible change in survival, DIPG remains at below 1% survival after 5 years. Prioritization of panobinostat through previous cooperative work resulted in a phase 1 clinical trial. Nonetheless, new therapies for DIPG must be identified to further dramatically change the statistics for DIPG. To identify novel therapy strategies for DIPG, we performed whole exome(16 new samples, 22 previously published samples, 38 in total with 26 matched normal) and RNA deep sequencing (17 new samples, 11 previously published samples) on a cohort of new patient samples. Sequencing results aid in the identification of recurrent mutations/variations and endotypic expression profiling to identify new therapeutic and treatment strategies for DIPG.
Characterizing TP53 and PPM1D Mutations as Resistance Drivers to Radiation Therapy in Diffuse Intrinsic Pontine Gliomas
Pediatric high-grade gliomas (pHGGs), encompassing diffuse midline gliomas (DMGs) and hemispheric tumors, represent the most common cause of cancer-related deaths in children age 0-14 years. Over the last decade, several landmark papers have revealed recurrent single nucleotide variants (SNVs) in the core histones H3.3 and H3.1, co-occurring with alterations in the TP53 signaling pathway and receptor tyrosine kinases (RTKs). However, the contribution of structural variants (SVs) to gliomagenesis has not been systematically explored. We performed a comprehensive analysis of whole genome sequencing (WGS) data on pediatric high-grade gliomas (pHGGs) from 179 children, including 61 hemispheric tumors and 118 diffuse midline gliomas, or DMGs, of which 61 are novel to this study. Among the DMGs, 84 (71%) were from pre-treatment biopsies including 33 obtained from the first multi-institutional North American clinical trial to incorporate diagnostic biopsies. This represents the largest cohort of pretreatment DMGs with whole genome sequencing to date. This large cohort of whole genome sequences provides an unparalleled opportunity to assess significantly recurrent structural variants in pHGG and their associations with driver SNVs and SCNAs.
Diffuse Intrinsic Pontine Glioma
GEO Series GSE50025. Homo sapiens. 145 samples. Type: Expression profiling by array; Methylation profiling by array; Genome variation profiling by SNP array; SNP genotyping by SNP array.
Wnt5a and its downstream transcription factor Stat3 are therapeutic targets for diffuse intrinsic pontine gliomas
GEO Series GSE130407. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
A tumor suppression role for EZH2 in Diffuse Intrinsic Pontine Glioma pathogenesis
GEO Series GSE188450. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.