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195 results for “disinfectant”
Data from: Multi-omics investigation reveals benzalkonium chloride disinfectants alter sterol and lipid homeostasis in the mouse neonatal brain
Lipids are critical for neurodevelopment; therefore, disruption of lipid homeostasis by environmental chemicals is expected to have detrimental effects on this process. Previously, we demonstrated that the benzalkonium chlorides (BACs), a class of commonly used disinfectants, alter cholesterol biosynthesis and lipid homeostasis in neuronal cell cultures in a manner dependent on their alkyl chain length. However, the ability of BACs to reach the neonatal brain and alter sterol and lipid homeostasis during neurodevelopment in vivo has not been characterized. Therefore, the goal of this study was to use targeted and untargeted mass spectrometry and transcriptomics to investigate the effect of BACs on sterol and lipid homeostasis, and to predict the mechanism of toxicity of BACs on neurodevelopmental processes. After maternal dietary exposure to 120 mg BAC/kg body weight/day, we quantified BAC levels in the mouse neonatal brain, demonstrating for the first time that BACs can cross the blood-placental barrier and enter the developing brain. Transcriptomic analysis of neonatal brains using RNA sequencing revealed alterations in canonical pathways related to cholesterol biosynthesis, liver X receptor-retinoid X receptor (LXR/RXR) signaling, and glutamate receptor signaling. Mass spectrometry analysis revealed decreases in total sterol levels and downregulation of triglycerides and diglycerides, which were consistent with the upregulation of genes involved in sterol biosynthesis and uptake as well as inhibition of LXR signaling. In conclusion, these findings demonstrate that BACs target sterol and lipid homeostasis and provide new insights for the possible mechanisms of action of BACs as developmental neurotoxicants.
Toxicity Dataset for "Efficient solar disinfection (SODIS) using polypropylene based transparent jerrycans: An investigation into its effectiveness, viability, and water sample toxicity"
<p>Toxicity data including abosrbance and percentage viability obtainbed from research for three TJC Verison 1</p> <p> </p>
Dataset for: Cure or Curse? Simulation Indicates that Microbes Proliferate under Disinfection Measures in the Space Station
Open the record for dataset details and reuse information.
Patch Test of Benzalkonium Chloride Disinfectant Spray
ClinicalTrials.gov study NCT01762982. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Study to Evaluate the Safety and Effectiveness of a Contact Lens Cleaning and Disinfecting Solution
ClinicalTrials.gov study NCT05565937. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Lens Wearing Experience and Biocompatibility of a Marketed Multi-Purpose Disinfecting Solution in Silicone Hydrogel and Soft Contact Lens Wearers
ClinicalTrials.gov study NCT01484938. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Intraoperative Disinfection by Pulse Irrigation With Povidone-Iodine Solution in Spine Surgery
ClinicalTrials.gov study NCT03249363. IPD Sharing: UNDECIDED. Countries: 0. Publications: 36.
A Study to Evaluate the Cooling Sensation and Consumer Liking of a Skin Disinfectant Spray
ClinicalTrials.gov study NCT02106403. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Safety and Effectiveness Study of a New Contact Lens Cleaning and Disinfecting Solution
ClinicalTrials.gov study NCT02701556. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Passive Disinfection Cap Compliance Study
ClinicalTrials.gov study NCT03391960. IPD Sharing: NO. Countries: 1. Publications: 0.
A Multi-Center Investigation of Patient Acceptability of OPTI-FREE RepleniSH® Multi-Purpose Disinfecting Solution (MPDS)
ClinicalTrials.gov study NCT00772707. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Safety and Efficacy of an Investigational Multi-Purpose Disinfecting Solution
ClinicalTrials.gov study NCT01341977. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Lens Wearing Experience and Biocompatibility of a Multi-Purpose Disinfecting Solution (MPDS)
ClinicalTrials.gov study NCT01476722. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Adjunctive Steps for Disinfection of Teeth With Primary Endodontic Infections
ClinicalTrials.gov study NCT03537664. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Three Daily Wear Monthly Replacement Silicone Hydrogel Contact Lenses With Two Multi-purpose Disinfecting Solution Combinations
ClinicalTrials.gov study NCT04789382. IPD Sharing: NO. Countries: 1. Publications: 0.
Duodenoscope Disinfect Study
ClinicalTrials.gov study NCT02611648. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Post-Market Clinical Follow Up Study to Evaluate BD PureHub™ Disinfecting Cap Use on Needle-Free Connectors
ClinicalTrials.gov study NCT05130762. IPD Sharing: Not stated. Countries: 4. Publications: 0.
Chlorohexidine Versus Povidone Iodine as Apreoperative Ophthalmic Disinfectant
ClinicalTrials.gov study NCT03957291. IPD Sharing: Not stated. Countries: 0. Publications: 1.
Study of A New Contact Lens Cleaning and Disinfecting Solution
ClinicalTrials.gov study NCT01318577. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Alcon Multi-Purpose Disinfecting Solution Versus Renu Fresh Multi-Purpose Solution in Symptomatic Contact Lens Wearers
ClinicalTrials.gov study NCT01187355. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.