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756 results for “immune genes”
Data from: Contrasting patterns of selection and drift between two categories of immune genes in prairie-chickens
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Heterozygote advantage can explain the extraordinary diversity of immune genes
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Data from: Contracting patterns of diversity and population differentiation at the innate immunity gene Toll-like receptor 2 (TLR2) in two sympatric rodent species
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Data from: Habitat fragmentation differentially shapes neutral and immune gene variation in a tropical bird species
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Data from: DNA methylation predicts immune gene expression in introduced house sparrows (Passer domesticus)
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Data from: Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes
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Data from: Specific alleles at immune genes, rather than genome-wide heterozygosity, are related to immunity and survival in the critically endangered Attwater's prairie-chicken
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Data from: Whole transcriptome analysis reveals changes in expression of immune related genes during and after bleaching in a reef-building coral
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Data from: Transcriptome profiling of immune tissues reveals habitat-specific gene expression between lake and river sticklebacks
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Data from: Patterns of diversity and spatial variability of β-defensin innate immune genes in a declining wild population of tree swallows
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Evidence for reduced immune gene diversity and activity during the evolution of termites
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Nucleotide diversity of functionally different groups of immune response genes in Old World camels based on newly annotated and reference-guided assemblies
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Data from: Immune response genes and pathogen presence predict migration survival in wild salmon smolts
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Data from: Dealing with the adaptive immune system during de novo evolution of genes from intergenic sequences
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Data from: Possible influence of B chromosomes on genes included in immune response and parasite burden in Apodemus flavicollis
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Innate and adaptive immune genes associated with MERS-CoV infection in dromedaries
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Data from: Widespread dysregulation of long non-coding genes associated with fatty acid metabolism, cell division, and immune response gene networks in xenobiotic-exposed rat liver
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Evolution of an insect immune barrier through horizontal gene transfer mediated by a parasitic wasp
<p>Numerical data that underlies tables and graphs (figures 1-7, 9, 10; table 1) and statistics of the PLOS Genetics article from Di Lelio et al., 2019.</p>
Data from: Molecular evolution in immune genes across the avian tree of life
All organisms encounter pathogens, and birds are especially susceptible to infection by malaria parasites and other haemosporidians. It is important to understand how immune genes, primarily innate immune genes which are the first line of host defense, have evolved across birds, a highly diverse group of tetrapods. Here, we find that innate immune genes are highly conserved across the avian tree of life and that although most show evidence of positive or diversifying selection within specific lineages or clades, the number of sites is often proportionally low in this broader context of putative constraint. Rather, evidence shows a much higher level of negative or purifying selection in these innate immune genes – rather than adaptive immune genes – which is consistent with birds' long coevolutionary history with pathogens and the need to maintain a rapid response to infection. We further explored avian responses to haemosporidians by comparing differential gene expression in wild birds (1) uninfected with haemosporidians, (2) infected with Plasmodium and (3) infected with Haemoproteus (Parahaemoproteus). We found patterns of significant differential expression with some genes unique to infection with each genus and a few shared between 'treatment' groups, but none that overlapped with the genes included in the phylogenetic study.
Data from: Repurposed transcriptomic data facilitate discovery of innate immunity Toll-Like Receptor (TLR) genes across Lophotrochozoa
The growing volume of genomic data from across life represents opportunities for deriving valuable biological information from data that were initially collected for another purpose. Here, we use transcriptomes collected for phylogenomic studies to search for toll-like receptor (TLR) genes in poorly sampled lophotrochozoan clades (Annelida, Mollusca, Brachiopoda, Phoronida, and Entoprocta) and one ecdysozoan clade (Priapulida). TLR genes are involved in innate immunity across animals by recognizing potential microbial infection. They have an extracellular leucine-rich repeat (LRR) domain connected to a transmembrane domain and an intracellular toll/interleukin-1 receptor (TIR) domain. Consequently, these genes are important in initiating a signaling pathway to trigger defense. We found at least one TLR ortholog in all but two taxa examined, suggesting that a broad array of lophotrochozoans may have innate immune systems similar to those observed in vertebrates and arthropods. Comparison to the SMART database confirmed the presence of both the LRR and the TIR protein motifs characteristic of TLR genes. Because we looked at only one transcriptome per species, discovery of TLR genes was limited for most taxa. However, several TRL-like genes that vary in the number and placement of LRR domains were found in phoronids. Additionally, several contigs contained LRR domains but lacked TIR domains, suggesting they were not TLRs. Many of these LRR-containing contigs had other domains (e.g., immunoglobin) and are likely involved in innate immunity.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.