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Dataset results
612 results for “imprinting”
Metabolic Imprints of Alcoholic Beverages
ClinicalTrials.gov study NCT03384147. IPD Sharing: YES. Countries: 1. Publications: 1.
Lung Cancer Diagnosis by Detecting Epigenetic Imprinting Alterations in Bronchoalveolar Lavage
ClinicalTrials.gov study NCT05707585. IPD Sharing: NO. Countries: 1. Publications: 8.
Data from: Untangling phylogenetical, geometrical and ornamental imprints on Early Triassic ammonoid biogeography: a similarity-distance decay study.
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Data from: Paternal Imprinting of Mating Preferences Between Natural Populations of House Mice (Mus musculus domesticus)
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Data from: Mapping the imprint of biotic interactions on β-diversity
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Data from: Environmental and historical imprints on beta diversity: insights from variation in rates of species turnover along gradients
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Genetic imprints of Brosimum alicastrum (Moraceae) in Mexico
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Data from: Correlations between broad-scale taxonomic and genetic differentiations suggest a dominant imprint of historical processes on beta diversities
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Data from: Reinvestigation of Protelytron permianum (Insecta; Early Permian; USA) as an example for applying reflectance transformation imaging to insect imprint fossils
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Data from: The imprint of Cenozoic migrations and evolutionary history on the biogeographic gradient of body size in New World mammals
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Innate preference hierarchies coupled with adult experience, rather than larval imprinting or transgenerational acclimation, determine host plant use in Pieris rapae
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Data from: Imprinting can cause a maladaptive preference for infectious conspecifics
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Data from: Contrasted invasion processes imprint the genetic structure of an invasive scale insect across southern Europe
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Data from: Imprints from genetic drift and mutation imply relative divergence times across marine transition zones in a pan-European small pelagic fish (Sprattus sprattus)
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Data from: Diet-based assortative mating through sexual imprinting
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Data from: Defining conservation units in a stocking-induced genetic melting pot: unravelling native and multiple exotic genetic imprints of recent and historical secondary contact in Adriatic grayling
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Data from: The battle of the sexes over seed size: support for both kinship genomic imprinting and interlocus contest evolution
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Marginal imprint of human land use upon fire history in a mire-dominated boreal landscape of the Veps Highland, North-West Russia
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Data from: Monoallelic loss of the imprinted gene Grb10 promotes tumor formation in irradiated Nf1+/- mice
Imprinted genes are expressed from only one parental allele and heterozygous loss involving the expressed allele is sufficient to produce complete loss of protein expression. Genetic alterations are common in tumorigenesis but the role of imprinted genes in this process is not well understood. In earlier work we mutagenized mice heterozygous for the Neurofibromatosis I tumor suppressor gene (NF1) to model radiotherapy-associated second malignant neoplasms that arise in irradiated NF1 patients. Expression analysis of tumor cell lines established from our mouse models identified Grb10 expression as widely absent. Grb10 is an imprinted gene and polymorphism analysis of cell lines and primary tumors demonstrates that the expressed allele is commonly lost in diverse Nf1 mutant tumors arising in our mouse models. We performed functional studies to test whether Grb10 restoration or loss alter fundamental features of the tumor growth. Restoring Grb10 in Nf1 mutant tumors decreases proliferation, decreases soft agar colony formation and downregulates Ras signaling. Conversely, Grb10 silencing in untransformed mouse embryo fibroblasts significantly increased cell proliferation and increased Ras-GTP levels. Expression of a constitutively activated MEK rescued tumor cells from Grb10-mediated reduction in colony formation. These studies reveal that Grb10 loss can occur during in vivo tumorigenesis, with a functional consequence in untransformed primary cells. In tumors, Grb10 loss independently promotes Ras pathway hyperactivation, which promotes hyperproliferation, an early feature of tumor development. In the context of a robust Nf1 mutant mouse model of cancer this work identifies a novel role for an imprinted gene in tumorigenesis.
Data from: Genomic imprinting, disrupted placental expression, and speciation
The importance of regulatory incompatibilities to the early stages of speciation remains unclear. Hybrid mammals often show extreme parent-of-origin growth effects that are thought to be a consequence of disrupted genetic imprinting (parent-specific epigenetic gene silencing) during early development. Here we test the long-standing hypothesis that abnormal hybrid growth reflects disrupted gene expression due to loss of imprinting (LOI) in hybrid placentas, resulting in dosage imbalances between paternal growth factors and maternal growth repressors. We analyzed placental gene expression in reciprocal dwarf hamster hybrids that show extreme parent-of-origin growth effects relative to their parental species. In massively enlarged hybrid placentas, we observed both extensive transgressive expression of growth-related genes and bi-allelic expression of many genes that were paternally silenced in normal sized hybrids. However, the apparent widespread disruption of paternal silencing was coupled with reduced gene expression levels overall. These patterns are contrary to the predictions of the LOI model and indicate that hybrid misexpression of dosage sensitive genes is caused by other regulatory mechanisms in this system. Collectively, our results support a central role for disrupted gene expression and imprinting in the evolution of mammalian hybrid inviability, but call into question the generality of the widely invoked LOI model.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.