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172 results for “life development”
Data from: Slow development as an evolutionary cost of long life
Life-history theory predicts a trade-off between early-life fitness and life span. While the focus traditionally has been on the fecundity-life span trade-off, there are strong reasons to expect trade-offs with growth rate and/or development time. We investigated the roles of growth rate and development time in the evolution of life span in two independent selection experiments in the outcrossing nematode Caenorhabditis remanei. First, we found that selection under heat-shock leads to the evolution of increased life span without fecundity costs, but at the cost of slower development. Thereafter, the putative evolutionary links between development time, growth rate, fecundity, heat-shock resistance and life span were independently assessed in the second experiment by directly selecting for fast or slow development. This experiment confirmed our initial findings, since selection for slow development resulted in the evolution of long life span and increased heat-shock resistance. Because there were no consistent trade-offs with growth rate or fecundity, our results highlight the key role of development rate – differentiation of the somatic cells per unit of time – in the evolution of life span. Since development time is under strong selection in nature, reduced somatic maintenance resulting in shorter life span may be a widespread cost of rapid development.
Non-human primate white matter development during the first year of life as assessed by diffusion tensor imaging and quantitative relaxometry
<p>In this project, we use diffusion tensor imaging (DTI) and quantitative relaxometry (QR) metrics to assess longitudinal changes in white matter (WM) throughout the postnatal rhesus macaque brain across the first year of life. DTI and QR metrics are measured at 3, 7, 13, 25, and 53 weeks of age in each of 35 non-human primates (NHPs) in this sample, for a total 175 datapoints (i.e., scans). Leveraging a previously published NHP WM atlas (Adluru et al., 2012; Zakszewski et al., 2014), we assess WM microstructure in 76 WM regions across the brain. DTI metrics include fractional anisotropy (FA), mean diffusivity (MD), radial diffusivity (RD), and axial diffusivity (AD); the QR metric assessed is the longitudinal relaxation rate (qR<sub>1</sub>). These longitudinal data enable the direct comparison of DTI and QR metrics in very early life on a within-subject level, as well as robust, multimodal modeling of WM growth in infancy, providing insights into early postnatal neurodevelopment that may have important implications neuropsychiatric and neurodevelopmental disorders in childhood.</p>
Data from: Evolutionary consequence of a change in life cycle complexity: a link between precocious development and evolution towards female-biased sex allocation in a hermaphroditic parasite
The evolutionary consequences of changes in the complex life cycles of parasites are not limited to the traits that directly affect transmission. For instance, mating systems that are altered due to precocious sexual maturation in what is typically regarded as an intermediate host may impact opportunities for outcrossing. In turn, reproductive traits may evolve to optimize sex allocation. Here we test the hypothesis that sex allocation evolved towards a more female-biased function in populations of the hermaphroditic digenean trematode Alloglossidium progeneticum that can precociously reproduce in their second hosts. In these precocious populations, parasites are forced to self-fertilize as they remain encysted in their second hosts. In contrast, parasites in obligate 3-host populations have more opportunities to outcross in their third host. We found strong support that in populations with precocious development, allocation to male resources was greatly reduced. We also identified a potential phenotypically plastic response in a body size-sex allocation relationship that may be driven by the competition for mates. These results emphasize how changes in life cycle patterns that alter mating systems can impact the evolution of reproductive traits in parasites.
Data from: Ontogenetic timing as a condition-dependent life history trait: high-condition males develop quickly, peak early and age fast
Within-population variation in ageing remains poorly understood. In males, condition-dependent investment in secondary sexual traits may incur costs which limit ability to invest in somatic maintenance. Moreover, males often express morphological and behavioural secondary sexual traits simultaneously, but the relative effects on ageing of investment in these traits remain unclear. We investigated the condition-dependence of male life history in the neriid fly Telostylinus angusticollis. Using a fully factorial design, we manipulated male early-life condition by varying nutrient content of the larval diet and, subsequently, manipulated opportunity for adult males to interact with rival males. We found that high-condition males developed more quickly and reached their reproductive peak earlier in life, but also experienced faster reproductive ageing and died sooner than low-condition males. By contrast, interactions with rival males reduced male lifespan but did not affect male reproductive ageing. High condition in early life is therefore associated with rapid ageing in T. angusticollis males, even in the absence of damaging male-male interactions. Our results show that abundant resources during the juvenile phase are used to expedite growth and development and enhance early-life reproductive performance at the expense of late-life performance and survival, demonstrating a clear link between male condition and ageing.
Development and Validation of a Dementia Life Expectancy Tool
ClinicalTrials.gov study NCT06266325. IPD Sharing: NO. Countries: 0. Publications: 1.
Development of Dermatology-related Quality of Life Assessment in Patients Treated With Epidermal Growth Factor Receptor (EGFR) Inhibitors
ClinicalTrials.gov study NCT01015326. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Social and Emotional Development Support Program for Adolescents: Effects on Belonging, Meaning in Life, Authenticity, Well-Being, and Resilience
ClinicalTrials.gov study NCT07253636. IPD Sharing: NO. Countries: 1. Publications: 0.
Development of the Eye Motor System During the First 7 Months of Life in Infants With and Without a Family History of Cross-Eye
ClinicalTrials.gov study NCT00001143. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Ontogenetic timing as a condition-dependent life history trait: high-condition males develop quickly, peak early and age fast
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Data from: Development and validation of quality of life instruments for chronic diseases—chronic gastritis version 2 (QLICD-CG V2.0)
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Data from: Slow development as an evolutionary cost of long life
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Non-human primate white matter development during the first year of life as assessed by diffusion tensor imaging and quantitative relaxometry
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Data from: Evolutionary consequence of a change in life cycle complexity: a link between precocious development and evolution towards female-biased sex allocation in a hermaphroditic parasite
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Data from: Offspring development and life-history variation in a water flea depends upon clone-specific integration of genetic, non-genetic and environmental cues
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Chd8 haploinsufficiency impairs early brain development and impacts protein homeostasis later in life
GEO Series GSE142208. Mus musculus. 48 samples. Type: Expression profiling by high throughput sequencing.
Reduced microglial Trem2 levels is associated with abnormal synaptic pruning in the developing hippocampus of mice exposed to early life stress
GEO Series GSE190427. Mus musculus. 48 samples. Type: Other.
Early life stress perturbs the maturation of microglial in the developing hippocampus [P28]
GEO Series GSE81037. Mus musculus. 12 samples. Type: Other.
Early life stress perturbs the maturation of microglia in the developing hippocampus [development]
GEO Series GSE81035. Mus musculus. 12 samples. Type: Other.
Allergen-induced activation of NK cell genes represents an early life immune response in development of allergic asthma
GEO Series GSE96783. Homo sapiens. 513 samples. Type: Expression profiling by high throughput sequencing.
Early-life gut microbiome maturity regulates blood-brain barrier and cognitive development
GEO Series GSE291278. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.