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306 results for “mitral valve”
The Effects of Levosimendan During Mitral Valve Surgery
ClinicalTrials.gov study NCT01969071. IPD Sharing: Not stated. Countries: 1. Publications: 10.
Normal Values in Stress Echocardiographic Parameters in Patients After Successful Mitral Valve Repair for Organic MR
ClinicalTrials.gov study NCT02371863. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of Mitral Annular Disjunction in Mitral Valve Prolapse Patients and Arrhythmia Risk
ClinicalTrials.gov study NCT06741709. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Every day mitral valve reconstruction: what has changed over the last 15 years?
Open the record for dataset details and reuse information.
Figure 2b from: Cirillo M (2020) Ring-first Mitral Valve Repair. Research Ideas and Outcomes 6: e62369. https://doi.org/10.3897/rio.6.e62369
Figure 2b The two most frequent types of mitral pathology: Barlow's disease (a and b) and fibroelastic deficiency (c and d). The pathological pictures are shown and the advantage of implanting the prosthetic ring before performing the repair of the valve leaflets is illustrated. - By implanting the ring as a first step, the valve is arranged in the correct elliptical shape, the leaflets are spatially redistributed, then the judgment on any other necessary surgical act is taken in the final shape of the valve.
Figure 2a from: Cirillo M (2020) Ring-first Mitral Valve Repair. Research Ideas and Outcomes 6: e62369. https://doi.org/10.3897/rio.6.e62369
Figure 2a The two most frequent types of mitral pathology: Barlow's disease (a and b) and fibroelastic deficiency (c and d). The pathological pictures are shown and the advantage of implanting the prosthetic ring before performing the repair of the valve leaflets is illustrated. - In Barlow's disease, the mitral valve takes on a more rounded shape than the normal elliptical one and the tissue is very redundant;
Figure 2d from: Cirillo M (2020) Ring-first Mitral Valve Repair. Research Ideas and Outcomes 6: e62369. https://doi.org/10.3897/rio.6.e62369
Figure 2d The two most frequent types of mitral pathology: Barlow's disease (a and b) and fibroelastic deficiency (c and d). The pathological pictures are shown and the advantage of implanting the prosthetic ring before performing the repair of the valve leaflets is illustrated. - By implanting the ring as the first step, the valve area is reduced and assumes a more correct geometry, therefore the resection can be less extensive (triangular, dashed lines).
Figure 1 from: Cirillo M (2020) Ring-first Mitral Valve Repair. Research Ideas and Outcomes 6: e62369. https://doi.org/10.3897/rio.6.e62369
Figure 1 Normal anatomy of the left heart atrioventricular mitral valve (from https://commons.wikimedia.org/wiki/File:Mitral_Valve_RK.png, licensed CC0).
Figure 2c from: Cirillo M (2020) Ring-first Mitral Valve Repair. Research Ideas and Outcomes 6: e62369. https://doi.org/10.3897/rio.6.e62369
Figure 2c The two most frequent types of mitral pathology: Barlow's disease (a and b) and fibroelastic deficiency (c and d). The pathological pictures are shown and the advantage of implanting the prosthetic ring before performing the repair of the valve leaflets is illustrated. - In fibroelastic deficiency the mitral annulus is dilated by chronic regurgitation, widening the valvular area and this may induce a quite large (quadrangular, dashed lines) resection;
Data from: Dysregulation of valvular interstitial cell let-7c, miR-17, miR-20a, and miR-30d in naturally occurring canine myxomatous mitral valve disease
Canine myxomatous mitral valve disease (MMVD) resembles the early stages of myxomatous pathology seen in human non-syndromic mitral valve prolapse, a common valvular heart disease in the adult human population. Canine MMVD is seen in older subjects, suggesting age-related epigenetic dysregulation leading to derangements in valvular cell populations and matrix synthesis or degradation. We hypothesized that valvular interstitial cells (VICs) undergo disease-relevant changes in miRNA expression. In primary VIC lines from diseased and control valves, miRNA expression was profiled using RT-qPCR and next generation sequencing. VICs from diseased valves showed phenotypic changes consistent with myofibroblastic differentiation (vimentinlow+, a-SMAhigh+), increases in senescence markers (p21, SA-b-gal), and decreased cell viability and proliferation potential. RT-qPCR and miRNA sequencing analyses both showed significant (p<0.05) downregulation of let-7c, miR-17, miR-20a, and miR-30d in VICs from diseased valves compared to controls. Decreased let-7c, miR-17, and miR-20a may contribute to myofibroblastic differentiation in addition to cell senescence, and decreased miR-30d may disinhibit cell apoptosis. These data support the hypothesis that epigenetic dysregulation plays an important role in age-related canine MMVD.
Cardiovalve Transfemoral Mitral Valve System
ClinicalTrials.gov study NCT03813524. IPD Sharing: NO. Countries: 1. Publications: 0.
Evaluation of Right Ventricular Function Post Mitral Valve Operations
ClinicalTrials.gov study NCT05620992. IPD Sharing: Not stated. Countries: 0. Publications: 5.
The Papillary Muscle Approximation Provide Stability of Mitral Valve Repair for Ischemic Mitral Regurgitation
ClinicalTrials.gov study NCT03038204. IPD Sharing: YES. Countries: 0. Publications: 7.
Safety and Performance Study of the Harpoon Mitral Valve Repair System
ClinicalTrials.gov study NCT03285724. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Feasibility Study of the Tendyne Mitral Valve System in Mitral Annular Calcification
ClinicalTrials.gov study NCT03539458. IPD Sharing: NO. Countries: 1. Publications: 0.
Surgical Implantation of TRAnscatheter vaLve in Native Mitral Annular Calcification (SITRAL) Study
ClinicalTrials.gov study NCT02830204. IPD Sharing: NO. Countries: 1. Publications: 0.
Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation
ClinicalTrials.gov study NCT03433274. IPD Sharing: NO. Countries: 2. Publications: 0.
Patient Specific Mitral Valve Modeling for Surgical Planning and Training
ClinicalTrials.gov study NCT03609931. IPD Sharing: NO. Countries: 0. Publications: 1.
Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure
ClinicalTrials.gov study NCT00608140. IPD Sharing: Not stated. Countries: 2. Publications: 0.
Rapid and Easy Evaluation of Cardiac Systolic Function by Means of Mitral Valve Movements in the Emergency Department
ClinicalTrials.gov study NCT02657824. IPD Sharing: NO. Countries: 0. Publications: 3.
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