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128
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Dataset results
128 results for “model fit”
PARK-FIT. Treadmill vs Cycling in Parkinson´s Disease. Definition of the Most Effective Model in Gait Reeducation
ClinicalTrials.gov study NCT04194762. IPD Sharing: NO. Countries: 1. Publications: 2.
Evaluating the Clinical Effectiveness of a Community-based Hearing Aid Fitting Service Delivery Model Facilitated by Community Healthcare Workers (CHWs) Providing Smartphone-based In-situ and Pre-set
ClinicalTrials.gov study NCT06982716. IPD Sharing: NO. Countries: 1. Publications: 6.
Data from: Estimating the relative fitness of escaped farmed salmon offspring in the wild and modeling the consequences of invasion for wild populations
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Data from: Successful by chance? the power of mixed models and neutral simulations for the detection of individual fixed heterogeneity in fitness components
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Data from: Is plant fitness proportional to seed set? An experiment and a spatial model
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Data from: Assessing the dynamics of natural populations by fitting individual based models with approximate Bayesian computation
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Data from: Are pollination "syndromes" predictive? Asian dalechampia fit neotropical models
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Fitting and evaluating univariate and multivariate models of within-lineage evolution
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R code from: Diagnosing common sources of lack of fit to composition data in fisheries stock assessment models using One-Step-Ahead (OSA) residuals
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Data from: Does one model fit all? patterns of beech mortality in natural forests of three European regions
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Data from: Genomic evidence of genetic variation with pleiotropic effects on caterpillar fitness and plant traits in a model legume
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Data from: Heterogeneity in genetic diversity among non-coding loci fails to fit neutral coalescent models of population history
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Data from: Integrated species distribution models fitted in INLA are sensitive to mesh parameterisation
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Data from: Identifying 'useful' fitness models: balancing the benefits of added complexity with realistic data requirements in models of individual plant fitness
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Learning protein fitness models from evolutionary and assay-labeled data
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data from "The chloroplast land plant phylogeny: analyses employing better-fitting tree- and site-heterogeneous composition models"
<p>The nucleotide, codon-degenerate and protein concatenated alignments of 83 chloroplast genes, with the respective character sets, in nexus format.</p>
Data from: Selection, genome-wide fitness effects and evolutionary rates in the model legume Medicago truncatula
Sequence data for >20 000 annotated genes from 56 accessions of Medicago truncatula were used to identify potential targets of positive selection, the determinants of evolutionary rate variation and the relative importance of positive and purifying selection in shaping nucleotide diversity. Based upon patterns of intraspecific diversity and interspecific divergence, c. 50–75% of nonsynonymous polymorphisms are subject to strong purifying selection and 1% of the sampled genes harbour a signature of positive selection. Combining polymorphism with expression data, we estimated the distribution of fitness effects and found that the proportion of deleterious mutations is significantly greater for expressed genes than for genes with undetected transcripts (nonexpressed) in a previous RNA-seq experiment and greater for broadly expressed genes than those expressed in only a single tissue. Expression level is the strongest correlate of evolutionary rates at nonsynonymous sites, and despite multiple genomic features being significantly correlated with evolutionary rates, they explain less than 20% of the variation in nonsynonymous rates (dN) and <15% of the variation in either synonymous rates (dS) or dN:dS. Among putative targets of selection were genes involved in defence against pathogens and herbivores, genes with roles in mediating the relationship with rhizobial symbionts and one-third of annotated histone-lysine methyltransferases. Adaptive evolution of the methyltransferases suggests that positive selection in gene expression may have occurred through evolution of enzymes involved in epigenetic modification.
Data from: Modeling and quantifying frequency-dependent fitness in microbial populations with cross-feeding interactions
Coexistence of two or more populations by frequency-dependent selection is common in nature, and it often arises even in well-mixed experiments with microbes. If ecology is to be incorporated into models of population genetics, then it is important to represent accurately the functional form of frequency-dependent interactions. However, measuring this functional form is problematic for traditional fitness assays, which assume a constant fitness difference between competitors over the course of an assay. Here, we present a theoretical framework for measuring the functional form of frequency-dependent fitness by accounting for changes in abundance and relative fitness during a competition assay. Using two examples of ecological coexistence that arose in a long-term evolution experiment with Escherichia coli, we illustrate accurate quantification of the functional form of frequency-dependent relative fitness. Using a Monod-type model of growth dynamics, we show that two ecotypes in a typical cross-feeding interaction—such as when one bacterial population uses a byproduct generated by another—yields relative fitness that is linear with relative frequency.
Data from: Patterns of male fitness conform to predictions of evolutionary models of late-life
We studied lifetime male virility, a male fitness component, in five populations of Drosophila melanogaster. Virility was measured as the number of females, out of eight total, that a male could fertilize in 24 hours. Individual males were measured at weekly intervals until they died. Virility declined in an approximately linear fashion for the first three weeks of adult life. It then stayed low but relatively constant for another three weeks, exhibiting a clear plateau. These observations are consistent with the evolutionary theories of late-life.The results were not consistent with a simple heterogeneity theory of late-life. This is the first demonstration of a late-life plateau for a male fitness component. We also found that the virility of males that were within seven days of death was significantly lower than similarly aged males that were not about to die. This rapid deterioration of virility prior to death, or death spiral, is similar to a decline in fecundity that we had previously documented.
Data from: The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection
Malaria infections normally consist of more than one clonally-replicating lineage. Within-host interactions between sensitive and resistant parasites can have profound effects on the evolution of drug resistance. Here, using the Plasmodium chabaudi mouse malaria model, we ask whether the costs and benefits of resistance are affected by the number of co-infecting strains competing with a resistant clone. We found strong competitive suppression of resistant parasites in untreated infections and marked competitive release following treatment. The magnitude of competitive suppression depended on competitor identity. However, there was no overall effect of the diversity of susceptible parasites on the extent of competitive suppression or release. If these findings generalize, then transmission intensity will impact on resistance evolution because of its effect on the frequency of mixed infections, not because of its effect on the distribution of clones per host. This would greatly simplify the computational problems of adequately capturing within-host ecology in models of drug resistance evolution in malaria.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.