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Dataset results
254 results for “painful neuropathy”
Oral Thiamine for the Treatment of Painful Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT00279266. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy
ClinicalTrials.gov study NCT00321672. IPD Sharing: Not stated. Countries: 0. Publications: 2.
A Phase II/III Double-Blind Study of Amitriptyline and Mexiletine for Painful Neuropathy in HIV Infection
ClinicalTrials.gov study NCT00000793. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Functional Magnetic Resonance Imaging of Brain Activity in Patients With Painful Diabetic Neuropathy
ClinicalTrials.gov study NCT03700502. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Trial to Assess the Efficacy and Safety of SPM 927 (200, 400, and 600mg/Day) in Subjects With Painful Distal Diabetic Neuropathy
ClinicalTrials.gov study NCT00135109. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Figure 1 from: Hristov M, Sabit Z, Kirilov T, Bakalov D, Tzoneva R, Apostolova S, Georgieva I, Andreeva-Gateva P (2024) Effects of riboflavin on hyperalgesia and serum glutamine-to-glutamate ratio in rats with painful diabetic neuropathy. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e120921
Figure 1 Effects of riboflavin on changes in pain threshold were investigated using the paw pressure test. Streptozotocin administration significantly induced mechanical hyperalgesia by reducing the mechanical threshold and enhancing paw withdrawal responses, while supplementation with Vitamin B2 effectively mitigated mechanical hyperalgesia. Significant differences compared to the control group (Normal) are denoted as *P < 0.05, while significant differences compared to the diabetic group (Diabetic) are denoted as ##P < 0.01. n=8 animals per group.
Figure 3 from: Hristov M, Sabit Z, Kirilov T, Bakalov D, Tzoneva R, Apostolova S, Georgieva I, Andreeva-Gateva P (2024) Effects of riboflavin on hyperalgesia and serum glutamine-to-glutamate ratio in rats with painful diabetic neuropathy. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e120921
Figure 3 Effects of riboflavin on changes in pain threshold were investigated using the formalin test. The ends of the boxes depict the 25th and 75th percentiles, with a line at the median, while error bars extend to the 10th and 90th percentiles. During phase 1 of the formalin test, neither the vehicle-treated diabetic group nor the introduction of riboflavin showed significant changes in nociceptive behavior compared to the control group. In phase 2, the vehicle-treated diabetic group exhibited increased nociceptive behavior, while the addition of 25 mg or 50 mg of vitamin B2 significantly alleviated formalin-induced hyperalgesia. Significant differences compared to the control group (Normal) are indicated as *P < 0.05. Significant differences compared to the diabetic group (Diabetic) are indicated as #P < 0.05. n=8 animals per group.
Figure 2 from: Hristov M, Sabit Z, Kirilov T, Bakalov D, Tzoneva R, Apostolova S, Georgieva I, Andreeva-Gateva P (2024) Effects of riboflavin on hyperalgesia and serum glutamine-to-glutamate ratio in rats with painful diabetic neuropathy. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e120921
Figure 2 Effects of riboflavin on changes in pain threshold were investigated using the cold plate. Streptozotocin administration induced significant cold-induced hyperalgesia, alleviated notably by riboflavin in drinking water. Significant differences compared to the control group (Normal) are indicated as ***P < 0.001. Significant differences compared to the diabetic group (Diabetic) are indicated as #P < 0.05 and ###P < 0.001. n=8 animals per group.
Figure 4 from: Hristov M, Sabit Z, Kirilov T, Bakalov D, Tzoneva R, Apostolova S, Georgieva I, Andreeva-Gateva P (2024) Effects of riboflavin on hyperalgesia and serum glutamine-to-glutamate ratio in rats with painful diabetic neuropathy. Pharmacia 71: 1-7. https://doi.org/10.3897/pharmacia.71.e120921
Figure 4 Box plot illustrating the effect of riboflavin supplementation on the serum glutamine-to-glutamate ratio in diabetic rats. The ends of the boxes depict the 25th and 75th percentiles, with a line at the median, while error bars extend to the 10th and 90th percentiles. Riboflavin supplementation in the drinking water significantly altered the serum glutamine-to-glutamate ratio in diabetic rats with neuropathic pain, with a significant difference found only between the "Diabetic" and "Diabetic + Rf 50 mg" groups. Significant differences compared to the diabetic group (Diabetic) are indicated as *p < 0.05. n=8 animals per group.
Extension of Phase 3 Gene Therapy for Painful Diabetic Neuropathy
ClinicalTrials.gov study NCT04055090. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study to Evaluate the Efficacy, Safety, and Tolerability of Tapentadol ER Compared With Placebo in Patients With Chronic, Painful Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT01041859. IPD Sharing: Not stated. Countries: 3. Publications: 0.
The Effect of Yoga on Nerve Pain Caused by Chemotherapy (Chemotherapy-Induced Peripheral Neuropathy)
ClinicalTrials.gov study NCT05121558. IPD Sharing: YES. Countries: 1. Publications: 0.
Ricolinostat in Patients With Painful Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT03176472. IPD Sharing: NO. Countries: 1. Publications: 0.
Efficacy and Safety of MEDI7352 in Participants With Painful Diabetic Neuropathy
ClinicalTrials.gov study NCT03755934. IPD Sharing: Not stated. Countries: 5. Publications: 0.
A Study of Sativex® for Pain Relief Due to Diabetic Neuropathy
ClinicalTrials.gov study NCT00710424. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study to Assess Safety and Efficacy of Engensis in Painful Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT04469270. IPD Sharing: Not stated. Countries: 1. Publications: 0.
EPPIC-Net: Platform Protocol to Assess Treatments for Painful Diabetic Peripheral Neuropathy
ClinicalTrials.gov study NCT05476276. IPD Sharing: NO. Countries: 1. Publications: 0.
Study of Sulfasalazine in Treating Painful Neuropathy
ClinicalTrials.gov study NCT01667029. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Study Evaluating Long-term Safety and Efficacy of Lacosamide in Subjects With Painful Distal Diabetic Neuropathy.
ClinicalTrials.gov study NCT00546351. IPD Sharing: Not stated. Countries: 15. Publications: 0.
Study of NGX-4010 for the Treatment of Painful HIV-Associated Neuropathy (HIV-AN) or Postherpetic Neuralgia (PHN)
ClinicalTrials.gov study NCT00233155. IPD Sharing: Not stated. Countries: 0. Publications: 1.
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Allen Brain Atlas
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.