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183
datasets available to search
ShareScore release 0.9.0
Dataset results
183 results for “secretome”
Widespread multi-targeted therapy resistance via drug-induced secretome fucosylation
GEO Series GSE160205. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
The Therapeutic Potential of Adipose-Derived Mesenchymal Stem Cell Secretome in Osteoarthritis: A Comprehensive Study
GEO Series GSE239343. Homo sapiens. 12 samples. Type: Expression profiling by array.
Effect of resistant secretome on immune cells
GEO Series GSE296066. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Anti-HER2/neu TCR-T Cells in Action: Linking Transcriptional Signatures, Secretomics, and In Vivo Tumor Suppression
GEO Series GSE311201. Homo sapiens. 1 samples. Type: Expression profiling by high throughput sequencing.
Investigation of gene expression changes in normal human dermal fibroblasts after exposure to bone marrow mesenchymal stromal cell secretome
GEO Series GSE251807. Homo sapiens. 32 samples. Type: Expression profiling by high throughput sequencing.
Distinct miRNA profiles in human amniotic tissue and its vesicular and non-vesicular secretome
GEO Series GSE306157. Homo sapiens. 24 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Immune transcriptome and secretome differ between CD71+ Erythroid Cells from adult bone marrow and fetal liver parenchyma
GEO Series GSE199228. Homo sapiens. 8 samples. Type: Other.
The secretome of irradiated peripheral blood mononuclear cells attenuates activation of mast cells and basophils
GEO Series GSE202544. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
p21 produces a bioactive secretome that places stressed cells under immuno-surveillance [dataset 7]
GEO Series GSE139569. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Secretome from iPSC-derived MSCs exerts proangiogenic and immunosuppressive effects to alleviate radiation-induced vascular endothelial cell damage
GEO Series GSE271374. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Comparative genomic, transcriptomic and secretomic profilings of Penicillium oxalicum HP7-1 and its cellulase and xylanase hyper-producing mutant EU2106, and identification of two novel regulators for
GEO Series GSE80076. Penicillium oxalicum. 6 samples. Type: Expression profiling by high throughput sequencing.
Defining the Secrebiome: the expressed secretome of the gut microbiome and its role in obese Mexican children
GEO Series GSE143207. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Proteome and secretome analysis reveals differential post-transcriptional regulation of Toll-like receptor responses
GEO Series GSE85448. Mus musculus. 24 samples. Type: Expression profiling by array.
Adipose-derived stromal cell secretome reduces TNFα-induced hypertrophy and catabolic markers in primary human articular chondrocytes
<p>Datasets of the paper 'Adipose-derived stromal cell secretome reduces TNFα-induced hypertrophy and catabolic markers in primary human articular chondrocytes'</p>
Comparison of the secretome of follicle cells during developmental phagoptosis and starvation-induced apoptotic death of nurse cells in Drosophila melanogaster oogenesis.
<p>Associated preprint - https://www.biorxiv.org/content/10.1101/2024.03.12.584558v1</p> <p><strong>Keywords </strong></p> <p>secretome, Drosophila, oogenesis, cell death, HRP-KDEL</p> <p><strong>Sample Processing Protocol</strong></p> <p>pDisplay-ss-V5-HRPKDEL was obtained from Dr. Alice Ting (Stanford).The insert was PCR-amplified and cloned into the pENTR/D-TOPO cloning kit (Invitrogen) and pTW vector (Drosophila Genome Resource Center, RRID:DGRC_1129)) using Gateway cloning (Invitrogen). The plasmid was purified by Qiagen Midiprep kit, confirmed by sequencing and sent to BestGene (Chino Hills, CA) for injection into Drosophila embryos. Freshly dissected ovaries were incubated in 300 μL of 500 uM biotin phenol for 30 minutes at room temperature rotating. Samples were then rinsed with 1X PBS twice and the biotinylation reaction was initiated by adding 1 mM H2O2 in PBS to the samples for 1 minute and rotating at room temperature. Ovaries were quickly washed with quencher solution (10 mM sodium ascorbate, 5 mM Trolox (Sigma-Aldrich), 10 mM sodium azide, then lysed in 100 μL RIPA buffer with quencher solution for 5 min on ice. RIPA buffer was composed of: 50 μL 1M Tris-HCl, 150 μL 5M NaCl, 50 μL of 10% SDS, 250 μL of 10% Sodium Deoxycholate, 500 μL of 10% TritonX-100, 50 μL of 100X Protease Inhibitor (Sigma-Aldrich – P8849), 50 μL of 100 mM PMSF, 3.550 mL of diH20. Tissue was homogenized by motorized pestle and centrifuged at 16.1g for 10 min at 4°C. Clarified sample (clear middle layer) was transferred to a new tube and snap frozen in liquid nitrogen. Biotinylated proteins were pulled down using streptavidin magnetic beads. Beads from biotinylated protein pull-down were washed with 100 mM triethylammonium bicarbonate. Peptides were eluted from beads by on-bead trypsin digestion with 1μg Trypsin (Pierce) in 100 mM triethylammonium bicarbonate overnight rotating at 37°C. Peptides were desalted using C18 ZipTip (Millipore) and subjected liquid chromatography coupled to tandem mass spectrometry on a Q Exactive HF-X (Thermo Fisher Scientific). Data-dependent fragmentation used collision-induced dissociation.</p> <p><strong>Data Processing Protocol</strong></p> <p>RAW files were searched using MaxQuant under standard settings using the UniProt Drosophila melanogaster database, allowing for two missed trypsin cleavage sites, variable modifications for N-terminal acetylation, and methionine oxidation. Candidate peptides and protein identifications were filtered on the basis of a 1% false discovery rate.</p> <p><strong>Experiment Type</strong></p> <p>Data-dependent acquisition</p> <p><strong>Files included</strong></p> <p>MaxQuant search files - <br>tables.pdf<br>allPeptides.txt<br>evidence-mss.txt<br>evidence.txt<br>GlyGly_KSites.txt<br>HRPKDEL_dmel.xlsx<br>libraryMatch.txt<br>matchedFeatures.txt<br>modificationSpecificPeptides.txt<br>ms3Scans.txt<br>msms.txt<br>msmsScans.txt<br>msScans.txt<br>mzRange.txt<br>Oxidation_MSites.txt<br>parameters.txt<br>peptides.txt<br>Phospho_STYSites.txt<br>proteinGroups.txt<br>QQTGG_KSites.txt<br>summary.txt</p>
Dataset of Lipidomics of Cell Secretome Combined with the Study of Selected Bioactive Lipids in an In Vitro Model of Osteoarthritis
<p>Raw data of the paper "Lipidomics of Cell Secretome Combined with the Study of Selected Bioactive Lipids in an In Vitro Model of Osteoarthritis"</p>
Clinical Utility and Safety of Human Umbilical Cord Mesenchymal Stem Cell Secretome in Drug Resistant Epilepsy Single Center, Non-randomized, Phase I Clinical Trial
ClinicalTrials.gov study NCT06638970. IPD Sharing: YES. Countries: 1. Publications: 0.
The Bacterial Secretome in IBD
ClinicalTrials.gov study NCT04136587. IPD Sharing: NO. Countries: 1. Publications: 0.
Autologous Hair Follicle Secretome for Androgenic Alopecia (Single Site)
ClinicalTrials.gov study NCT07107841. IPD Sharing: NO. Countries: 1. Publications: 0.
The Placental Secretome as a Therapeutic Tool to Prevent Inflammation-induced Preterm Birth
ClinicalTrials.gov study NCT06891508. IPD Sharing: NO. Countries: 1. Publications: 0.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.